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52 条记录 (耗时 0.056 秒)

    Substituted thieno[3,2-d]pyrimidinones as MCHR1 antagonists and methods for using them
    13.
    发明授权
    Substituted thieno[3,2-d]pyrimidinones as MCHR1 antagonists and methods for using them 有权
    取代的噻吩并[3,2-d]嘧啶酮作为MCHR1拮抗剂及其使用方法

    公开(公告)号：US08618115B2

    公开(公告)日：2013-12-31

    申请号：US11586255

    申请日：2006-10-25

    申请人： William N. Washburn ,  Mark C. Manfredi ,  Jeffrey A. Robl ,  Andres S. Hernandez

    发明人： William N. Washburn ,  Mark C. Manfredi ,  Jeffrey A. Robl ,  Andres S. Hernandez

    IPC分类号： C07D495/04 ,  A61K31/519 ,  A61P3/04 ,  A61P3/10 ,  A61P25/22 ,  A61P25/24

    CPC分类号： C07D495/04

    摘要： The present application provides compounds, including all stereoisomers, solvates, prodrugs and pharmaceutically acceptable forms thereof according to Formula I. Additionally, the present application provides pharmaceutical compositions containing at least one compound according to Formula I and optionally at least one additional therapeutic agent. Finally, the present application provides methods for treating a patient suffering from an MCHR-1 modulated disease or disorder such as, for example, obesity, diabetes, depression or anxiety by administration of a therapeutically effective dose of a compound according to Formula I.

    摘要翻译： 本申请提供化合物，包括根据式I的所有立体异构体，溶剂合物，前药和药学上可接受的形式。另外，本申请提供含有至少一种根据式I的化合物和任选的至少一种另外的治疗剂的药物组合物。 最后，本申请提供了通过施用治疗有效剂量的根据式I的化合物治疗患有MCHR-1调节的疾病或病症例如肥胖，糖尿病，抑郁或焦虑的患者的方法。

    NON-BASIC MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS
    15.
    发明申请
    NON-BASIC MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS 有权
    非基础麦芽宁浓缩激素受体-1拮抗剂

    公开(公告)号：US20110034375A1

    公开(公告)日：2011-02-10

    申请号：US12907451

    申请日：2010-10-19

    申请人： William N. Washburn ,  Saleem Ahmad ,  Andres S. Hernandez

    发明人： William N. Washburn ,  Saleem Ahmad ,  Andres S. Hernandez

    IPC分类号： A61K31/53 ,  C07D495/04 ,  A61K31/5025 ,  A61K38/28 ,  A61K38/26 ,  A61K38/22 ,  A61P3/04 ,  A61P3/10 ,  A61P25/24 ,  A61P25/22

    CPC分类号： C07D495/04

    摘要： The present application provides compounds, including all stereoisomers, solvates, prodrugs and pharmaceutically acceptable forms thereof according to Formula I. Additionally, the present application provides pharmaceutical compositions containing at least one compound according to Formula I and optionally at least one additional therapeutic agent. Finally, the present application provides methods for treating a patient suffering from an MCHR-1 modulated disease or disorder such as, for example, obesity, diabetes, depression or anxiety by administration of a therapeutically effective dose of a compound according to Formula I. where R1, R1a, R1b, A, R3, R4, R5, R5b and R6 are as defined herein.

    摘要翻译： 本申请提供化合物，包括根据式I的所有立体异构体，溶剂合物，前药和药学上可接受的形式。另外，本申请提供含有至少一种根据式I的化合物和任选的至少一种另外的治疗剂的药物组合物。 最后，本申请提供了通过施用治疗有效剂量的根据式I的化合物治疗患有MCHR-1调节的疾病或病症例如肥胖，糖尿病，抑郁或焦虑的患者的方法。其中 R1，R1a，R1b，A，R3，R4，R5，R5b和R6如本文所定义。

    Substituted thieno[3,2-D]pyrimidines as non-basic melanin concentrating hormone receptor-1 antagonists
    16.
    发明授权
    Substituted thieno[3,2-D]pyrimidines as non-basic melanin concentrating hormone receptor-1 antagonists 有权
    取代的噻吩并[3,2-D]嘧啶作为非碱性黑色素浓缩激素受体-1拮抗剂

    公开(公告)号：US07745447B2

    公开(公告)日：2010-06-29

    申请号：US11586147

    申请日：2006-10-25

    申请人： William N. Washburn ,  Saleem Ahmad ,  Khehyong Ngu

    发明人： William N. Washburn ,  Saleem Ahmad ,  Khehyong Ngu

    IPC分类号： C07D495/04 ,  A61K31/519 ,  A61P25/22 ,  A61P3/04 ,  A61P3/10

    CPC分类号： C07D495/04

    摘要： The present application provides compounds, including all stereoisomers, solvates, prodrugs and pharmaceutically acceptable forms thereof according to Formula I. Additionally, the present application provides pharmaceutical compositions containing at least one compound according to Formula I and optionally at least one additional therapeutic agent. Finally, the present application provides methods for treating a patient suffering from an MCHR-1 modulated disease or disorder such as, for example, obesity, diabetes, depression or anxiety by administration of a therapeutically effective dose of a compound according to Formula I.

    摘要翻译： 本申请提供化合物，包括根据式I的所有立体异构体，溶剂合物，前药和药学上可接受的形式。另外，本申请提供含有至少一种根据式I的化合物和任选的至少一种另外的治疗剂的药物组合物。 最后，本申请提供了通过施用治疗有效剂量的根据式I的化合物治疗患有MCHR-1调节的疾病或病症例如肥胖，糖尿病，抑郁或焦虑的患者的方法。

    NON-BASIC MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS
    17.
    发明申请
    NON-BASIC MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS 有权
    非基础麦芽宁浓缩激素受体-1拮抗剂

    公开(公告)号：US20080269110A1

    公开(公告)日：2008-10-30

    申请号：US12109465

    申请日：2008-04-25

    申请人： William N. Washburn ,  Saleem Ahmad ,  Andres S. Hernandez

    发明人： William N. Washburn ,  Saleem Ahmad ,  Andres S. Hernandez

    IPC分类号： A61K38/28 ,  C07D495/04 ,  A61K31/53 ,  A61P3/04 ,  A61P25/00 ,  A61K38/22 ,  A61K31/5025

    CPC分类号： C07D495/04

    摘要： The present application provides compounds, including all stereoisomers, solvates, prodrugs and pharmaceutically acceptable forms thereof according to Formula I. Additionally, the present application provides pharmaceutical compositions containing at least one compound according to Formula I and optionally at least one additional therapeutic agent. Finally, the present application provides methods for treating a patient suffering from an MCHR-1 modulated disease or disorder such as, for example, obesity, diabetes, depression or anxiety by administration of a therapeutically effective dose of a compound according to Formula I where R1, R1a, R1b, A, R3, R4, R5, R5b and R6 are as defined herein.

    摘要翻译： 本申请提供化合物，包括根据式I的所有立体异构体，溶剂合物，前药和药学上可接受的形式。另外，本申请提供含有至少一种根据式I的化合物和任选的至少一种另外的治疗剂的药物组合物。 最后，本申请提供了通过施用治疗有效剂量的式I化合物治疗患有MCHR-1调节疾病或病症例如肥胖，糖尿病，抑郁或焦虑的患者的方法，其中R R 1，R 1b，R 1b，A，R 3，R 4， R 5，R 5和R 6如本文所定义。

    O-glucosylated benzamide SGLT2 inhibitors and method
    18.
    发明授权
    O-glucosylated benzamide SGLT2 inhibitors and method 有权
    O-葡萄糖基化苯甲酰胺SGLT2抑制剂及方法

    公开(公告)号：US06555519B2

    公开(公告)日：2003-04-29

    申请号：US09791186

    申请日：2001-02-23

    申请人： William N. Washburn

    发明人： William N. Washburn

    IPC分类号： A61K3135

    CPC分类号： C07H15/203

    摘要： SGLT2 inhibiting compounds are provided having the formula wherein n is 0, 1 or 2; A is  or heteroaryl which may contain 1 to 4 heteroatoms in the ring which may be selected from N, O, S, SO, and/or SO2, bearing substituents R3 and R4; and R1 to R4 are as defined herein. A method is also provided for treating diabetes and related diseases employing an SGLT2 inhibiting amount of the above compound alone or in combination with one, two or more other antidiabetic agents and/or one, two or more hypolipidemic agents.

    摘要翻译： 提供的SGLT2抑制化合物，其具有式1或2; A是或可以在环中含有1至4个杂原子的杂芳基，其可以选自N，O，S，SO和/或SO 2，带有取代基R 3 还提供了使用上述化合物的SGLT2抑制量单独或与一种，两种或更多种其它抗糖尿病药物和/或其它抗糖尿病药物组合治疗糖尿病和相关疾病的方法， 两种或多种降血脂药。