公开(公告)号：US08800347B2

公开(公告)日：2014-08-12

申请号：US13278214

申请日：2011-10-21

申请人： Russell Bonaventura ,  David G. Kelkenberg ,  David L. Beverly ,  Donald E. Miller ,  David A. Luce

发明人： Russell Bonaventura ,  David G. Kelkenberg ,  David L. Beverly ,  Donald E. Miller ,  David A. Luce

IPC分类号： G01L27/00

CPC分类号： A61B3/165 ,  G01L27/002

摘要： A tool for calibrating a non-contact tonometer (NCT) comprises a body having a mating feature configured for removably mounting the body on the nosepiece or on the measurement head of the NCT, a pressure sensor carried by the body and arranged to receive an air pulse discharged by the NCT to provide a pressure signal in response to the air pulse, and a radiation emitter carried by the body, wherein the radiation emitter provides a pseudo-applanation event when the pressure signal reaches a predetermined level that is detectable by the NCT as though an actual corneal applanation had taken place. In one embodiment, the mating feature includes a mounting orifice for receiving a portion of the nosepiece. In another embodiment, the mating feature includes a pair of mounting pins sized for receipt by a corresponding pair of mounting holes in the measurement head of the NCT.

摘要翻译： 用于校准非接触式眼压计（NCT）的工具包括具有配置特征的主体，该配合特征被配置为将主体可拆卸地安装在鼻甲管或NCT的测量头上，压力传感器由主体承载并布置成接收空气 由NCT放电的脉冲以响应于空气脉冲提供压力信号，以及由身体携带的辐射发射器，其中当压力信号达到可被NCT检测到的预定水平时，辐射发射器提供假压平事件 好像发生了一个实际的角膜压迫。 在一个实施例中，配合特征包括用于接收鼻梁的一部分的安装孔。 在另一个实施例中，配合特征包括一对安装销，其尺寸适于由NCT的测量头中的相应的一对安装孔接收。

公开(公告)号：US07909765B2

公开(公告)日：2011-03-22

申请号：US12335566

申请日：2008-12-16

申请人： David A. Luce

发明人： David A. Luce

IPC分类号： A61B3/16

CPC分类号： A61B3/165

摘要： A method and apparatus for measuring intraocular pressure of an eye use an empirically derived function wherein an inward applanation pressure P1 and an outward applanation pressure P2 obtained during a corneal deformation cycle caused by a fluid pulse are separately weighted so as to minimize cornea-related influence on the intraocular pressure value calculated by the function. In one embodiment, the function is optimized, at least in part, to minimize change in calculated IOP between measurements made before surgical alteration of the cornea and measurements made after surgical alteration of the cornea.

摘要翻译： 用于测量眼睛眼压的方法和装置使用经验导出的功能，其中在由流体脉冲引起的角膜变形循环期间获得的向内压迫压力P1和向外压迫压力P2被分别加权，以便最小化与角膜相关的影响 对由功能计算出的眼内压值。 在一个实施例中，该功能被优化，至少部分地最小化在角膜手术改变之前进行的测量和角膜手术改变后进行的测量之间的计算IOP的变化。

公开(公告)号：US07771353B2

公开(公告)日：2010-08-10

申请号：US11279269

申请日：2006-04-11

申请人： David A. Luce

发明人： David A. Luce

IPC分类号： A61B3/16

CPC分类号： A61B3/101

摘要： Tear film is measured without contacting the eye by comparing reflectance from the eye when the tear film is undisturbed with reflectance from the eye when the when the tear film is disturbed. If the reflectance levels differ somewhat, it is an indication that a healthy tear film exhibiting good specular reflection was present initially and was disturbed by the air pulse. However, if the reflectance levels are close to one another, it is an indication that a less-than-normal tear film was present initially (dry eye). In a described embodiment, tear film is disturbed by an air pulse directed at the eye, and a photosensitive detector is positioned to receive light from an illumination beam after the beam is reflected by the eye to generate a reflectance signal. The reflectance signal is evaluated to calculate a tear film index.

摘要翻译： 通过比较当泪液膜不受干扰时眼睛的反射率与来自眼睛的反射率相比较时眼睛的反射率不会与眼睛接触来测量撕裂膜。 如果反射率水平有些不同，这表明最初出现良好镜面反射的健康的泪膜，并被空气脉冲扰乱。 然而，如果反射率水平彼此接近，则表示初始存在小于正常的泪膜（干眼）。 在所描述的实施例中，泪膜受到针对眼睛的空气脉冲的干扰，光敏检测器定位成在光束被眼睛反射之后接收来自照明光束的光，以产生反射信号。 评估反射信号以计算泪液指数。

公开(公告)号：US06817981B2

公开(公告)日：2004-11-16

申请号：US10186540

申请日：2002-07-01

申请人： David A. Luce

发明人： David A. Luce

IPC分类号： A61B316

CPC分类号： A61B3/165

摘要： A novel tonometry method wherein measured intraocular pressure corresponding to inward applanation of the cornea and corneal hysteresis derived from a pressure differential associated with inward and outward applanation events in the same measurement pulse allows comparison with a predetermined population normality function to avoid corneal effects so that the actual status of intraocular pressure can be ascertained. A dual mode non-contact tonometer allows selection between a standard measurement mode for patient comfort and an alternate measurement mode wherein pressure-time characteristics of the fluid pulse are varied to allow additional observation of corneal hysteresis associated with the dynamic measurement process for carrying out the novel tonometry method. Corresponding tonometry method embodiments include a method adapted for a contact tonometer and a method based on a pair of non-contact tonometer measurements taken using different air pulse pressure ramp rates.

摘要翻译： 一种新颖的眼压测量方法，其中测量的眼内压与对应于角膜内侧平坦度和角膜滞后相关，该压力差与来自相同测量脉冲中的向内和向外压扁事件相关联的压力差异允许与预定的群体正常功能进行比较以避免角膜效应， 可以确定眼压的实际状态。 双模式非接触式眼压计允许在用于患者舒适的标准测量模式和替代测量模式之间进行选择，其中改变流体脉冲的压力 - 时间特性以允许额外观察与动态测量过程相关联的角膜滞后，从而执行 新型眼压测定法。 对应的眼压计方法实施例包括适用于接触眼压计的方法和基于使用不同空气脉冲压力斜坡率进行的一对非接触眼压计测量的方法。

公开(公告)号：US4046049A

公开(公告)日：1977-09-06

申请号：US479539

申请日：1974-06-14

申请人： David A. Luce ,  Anthony Marchese

发明人： David A. Luce ,  Anthony Marchese

IPC分类号： G10H1/053 ,  G10H1/02 ,  G10H1/36 ,  H01C10/10

CPC分类号： G10H1/02 ,  Y10S84/25

摘要： An electronic synthesizer instrument incorporates bass pedals for the notes of the musical scale, together with foot control apparatus adapted to select and modify the tone quality of sounds produced by operation of the bass pedals. The foot control apparatus includes push button switches which are operated by the toe of an operator's foot, and slide controls which are positioned by the operator's foot. At least some of the switches are preset switches for selecting and controlling multiple combinations of the functional units of the synthesizer. The control state of the instrument is at all times indicated by readily observable indicating lights.

摘要翻译： 一个电子合成仪器包括音阶的音符的低音踏板，以及适用于选择和修改由低音踏板操作产生的声音的音质的脚踏控制装置。 脚踏控制装置包括由操作者的脚的脚趾操作的按钮开关和由操作者的脚定位的滑动控制。 至少一些开关是用于选择和控制合成器的功能单元的多个组合的预设开关。 仪器的控制状态始终由易观察到的指示灯指示。

公开(公告)号：US4028979A

公开(公告)日：1977-06-14

申请号：US588359

申请日：1975-06-19

申请人： David A. Luce

发明人： David A. Luce

IPC分类号： G10H1/055 ,  G10H1/18 ,  H03B5/24 ,  H03B27/00 ,  G10H1/02 ,  G10C3/12 ,  G10F1/00

CPC分类号： H03B5/24 ,  G10H1/0551 ,  G10H1/181 ,  H03B27/00

摘要： An electronic musical instrument has a ring oscillator incorporating a multiplicity of identical stages connected to form a ring with the output of each stage being connected to the input of the succeeding stage. Each stage has an RC time constant circuit which introduces a delay in the transmission of a signal from one stage to the next, in accordance with the value of the capacitance of the RC circuit. The capacitance is varied in response to the amount of pressure acting on a key of the keyboard of the musical instrument, and the interval between a succession of pulses presented to an output terminal of the oscillator is dependent upon the force with which the keys are depressed, and the positions within the output pulse train at which such delays are introduced is dependent upon the position of the keys of the keyboard. The output pulse train contains information identifying all of the operated keys of the keyboard and the force with which they are operated. This information is decoded to select one of a plurality of tones produced by a tone signal source, and is also decoded to produce such tones with amplitudes corresponding to the force with which their corresponding keys are depressed.

摘要翻译： 电子乐器具有环形振荡器，该环形振荡器并入多个相同的级，连接形成环，每级的输出连接到后级的输入端。 每个级具有RC时间常数电路，其根据RC电路的电容值引入从一级到下一级的信号传输的延迟。 电容响应于作用在乐器的键盘的键上的压力的量而变化，并且呈现给振荡器的输出端子的一系列脉冲之间的间隔取决于键被按下的力 ，并且输出脉冲序列中引入这种延迟的位置取决于键盘的键的位置。 输出脉冲列包含识别键盘的所有操作键和它们被操作的力的信息。 该信息被解码以选择由音调信号源产生的多个音调中的一个，并且还被解码以产生具有对应于其相应键被按下的力的幅度的这种音调。

公开(公告)号：US4027569A

公开(公告)日：1977-06-07

申请号：US588320

申请日：1975-06-19

申请人： David A. Luce ,  Anthony Marchese

发明人： David A. Luce ,  Anthony Marchese

IPC分类号： G10H1/055 ,  G10H1/02

CPC分类号： G10H1/0551 ,  Y10S84/07

摘要： A keyboard of an electronic musical instrument incorporates a plurality of variable capacitors, one for each key, with one conductor of each capacitor being connected for movement with an individual key of the keyboard toward and away from the other conductor, so as to vary the capacitance of the capacitor in accordance with the force with which the key is depressed.

摘要翻译： 电子乐器的键盘包括多个可变电容器，一个用于每个键，每个电容器的一个导体被连接用于与键盘的单个键朝向和远离另一个导体移动，以便改变电容 的电容器按照键被按下的力。

公开(公告)号：US09320430B2

公开(公告)日：2016-04-26

申请号：US12751281

申请日：2010-03-31

申请人： David A. Luce

发明人： David A. Luce

IPC分类号： A61B3/16 ,  A61B3/00

CPC分类号： A61B3/165 ,  A61B3/0025

摘要： In an ophthalmic instrument that directs a fluid pulse at a cornea to cause reversible deformation of the cornea and monitors the corneal deformation to generate a deformation signal, the shape of the deformation signal is analyzed with respect to deformation signal data from a statistical population of eyes to calculate a deformation signal score indicating a degree of probability that the deformation signal corresponds in shape to a normal deformation signal for normal eyes in the population. In calculating the deformation signal score, significant geometrical signal parameters are calculated and combined. The deformation signal score may be used as a basis to keep or discard intraocular pressure measurements in a non-contact tonometer, and/or as a basis to conduct further diagnostic screening.

摘要翻译： 在眼科仪器中，指示角膜上的流体脉冲引起角膜的可逆变形并监测角膜变形以产生变形信号，相对于来自统计学上的眼睛的变形信号数据分析变形信号的形状 计算出变形信号得分，其表示变形信号的形状对于群体中正常眼睛的正常变形信号的概率。 在计算变形信号得分时，计算并组合了重要的几何信号参数。 变形信号得分可以用作在非接触眼压计中保持或丢弃眼压测量的基础，和/或作为进一步诊断筛查的基础。

公开(公告)号：US07004902B2

公开(公告)日：2006-02-28

申请号：US10394833

申请日：2003-03-21

申请人： David A. Luce

发明人： David A. Luce

IPC分类号： A61B3/16

CPC分类号： A61B3/165 ,  A61B3/1005 ,  A61F2009/00872 ,  G06F19/00

摘要： A method for measuring a biomechanical characteristic of corneal tissue of a cornea comprises the steps of measuring a geometric parameter of the cornea, measuring hysteresis associated with deformation of the cornea, and evaluating the measured geometric parameter and hysteresis. In an ophthalmic system for practicing the method, a pachometer is used to measure corneal thickness and a tonometer is used to measure hysteresis, and the measurement data is supplied to a computer for evaluation. A related method for prequalifying LASIK patients comprises the steps of establishing a multi-dimensional space wherein a first dimension is a geometric corneal parameter and a second dimension is hysteresis associated with corneal deformation, measuring the geometric corneal parameter and hysteresis of the patient's cornea, registering the geometric corneal parameter and corneal hysteresis in a data point in the multi-dimensional space, and evaluating a location of the data point in the multi-dimensional space.

摘要翻译： 用于测量角膜角膜组织的生物力学特性的方法包括以下步骤：测量角膜的几何参数，测量与角膜变形相关的滞后，以及评估所测量的几何参数和滞后。 在用于实施该方法的眼科系统中，使用血压计来测量角膜厚度，并且使用眼压计来测量滞后，并将测量数据提供给计算机进行评估。 用于资格预测LASIK患者的相关方法包括建立多维空间的步骤，其中第一维度是几何角膜参数，第二维度是与角膜变形相关的滞后，测量患者角膜的几何角膜参数和滞后，登记 在多维空间中的数据点中的几何角膜参数和角膜滞后，以及评估多维空间中数据点的位置。

公开(公告)号：US06875175B2

公开(公告)日：2005-04-05

申请号：US10186572

申请日：2002-07-01

申请人： David A. Luce

发明人： David A. Luce

IPC分类号： A61B3/16

CPC分类号： A61B3/165

摘要： A dual mode non-contact tonometer allows selection between a standard measurement mode for patient comfort and an alternate measurement mode wherein pressure-time characteristics of the fluid pulse are varied to allow additional observation of corneal hysteresis associated with the dynamic measurement process. In the alternate measurement mode, measured intraocular pressure corresponding to inward applanation of the cornea and corneal hysteresis derived from a pressure differential associated with inward and outward applanation events in the same measurement pulse allows comparison with a predetermined population normality function to avoid corneal effects so that the actual status of intraocular pressure can be ascertained.

摘要翻译： 双模式非接触式眼压计允许在用于患者舒适的标准测量模式和替代测量模式之间进行选择，其中改变流体脉冲的压力 - 时间特性以允许对与动态测量过程相关联的角膜滞后的额外观察。 在替代测量模式中，与在相同测量脉冲中与向内和向外压扁事件相关联的压力差导致的角膜内角度和角膜迟滞相应的测量眼内压与允许与预定的群体正常功能相比较以避免角膜效应，从而 可以确定眼压的实际状况。