公开(公告)号：US4340764A

公开(公告)日：1982-07-20

申请号：US207613

申请日：1980-11-17

Applicant: David J. Milner

Inventor： David J. Milner

IPC: C07C45/00 ,  C07C45/59 ,  C07C49/203 ,  C07C67/00 ,  C07C45/57

CPC classification number: C07C45/59

Abstract: 1,4-Dialkylbut-2-ene-1,4-diones are obtained by oxidizing a 2,5-dialkylfuran with an aqueous solution of an inorganic hypochlorite at a pH from 7 to 10.

Abstract translation: 1,4-二烷基丁-2-烯-1,4-二酮是通过用无机次氯酸盐的水溶液在7至10的pH下氧化2,5-二烷基呋喃获得的。

公开(公告)号：US5304659A

公开(公告)日：1994-04-19

申请号：US57806

申请日：1993-05-07

Applicant: David J. Milner

Inventor： David J. Milner

IPC: C07C239/20 ,  C07D493/04 ,  C09B57/00 ,  D06P3/52 ,  C07D307/77

CPC classification number: C07D493/04 ,  C07C239/20 ,  C09B57/00

Abstract: A process for the preparation of a polycyclic dye of Formula (1): ##STR1## by reacting a compound of Formula (2): ##STR2## with a benzofuranone of the Formula (3): ##STR3## wherein: Ring A is unsubstituted or is substituted by from one to three groups;Ring B is unsubstituted, apart from the nitro group, or is substituted by one or two further groups;R is H, optionally substituted alkyl or optionally substituted aryl; andZ is an oxyammonium group, and certain novel compounds of Formula (2) are disclosed.The process provides a convenient route to polycyclic dyes which are useful for the coloration of synthetic textile materials particularly polyesters.

Abstract translation: 制备式（1）的多环染料的方法：（*化学结构*）式1通过使式（2）的化合物：（*化学结构*）式（2）与式（2）的苯并呋喃酮反应， 3）：（*化学结构*）式3其中：环A是未取代的或被一至三个基团取代; 环B除了硝基以外是未取代的，或被一个或两个另外的基团取代; R为H，任选取代的烷基或任选取代的芳基; Z是氧基铵基，并且公开了某些新的式（2）化合物。 该方法提供了多环染料的方便途径，其可用于合成纺织品特别是聚酯的着色。

公开(公告)号：US4383112A

公开(公告)日：1983-05-10

申请号：US167158

申请日：1980-07-08

Applicant: Dale A. Laidler ,  David J. Milner

Inventor： Dale A. Laidler ,  David J. Milner

IPC: B01J31/00 ,  C07B61/00 ,  C07D207/09 ,  C07D207/32 ,  C07D207/323 ,  C07D213/53 ,  C07D215/12 ,  C07F11/00 ,  C07F15/04 ,  C07D213/00 ,  C07D215/00

CPC classification number: C07D207/323 ,  C07D213/53 ,  C07D215/12

Abstract: Chiral Schiff bases according to the general formula: ##STR1## and transition metal complexes thereof, wherein C.sup.* is an asymmetric carbon atom, R.sup.1 and R.sup.2, which may be the same or different are alkyl, aralkyl, aryl or alkaryl, R.sup.3 is hydrogen, alkyl, aralkyl, aryl or alkaryl, R.sup.4 and R.sup.5, which may be the same or different, are hydrogen or lower alkyl or, where n is 1, may with the cyclic ring to which CR.sup.4 R.sup.5 is attached form a fused system, J is a chain of 3 or 4 atoms which may all be carbon atoms or may be a mixture of carbon atoms and one or more hetero atoms which may be the same or different, which chain with the group C K forms an aromatic system, K is nitrogen, ##STR2## or --NH--, L, each of which may be the same or different, represents a substituent attached to a carbon atom in the chain J and is hydrogen, alkyl, aralkyl, alkaryl, aryl or a substituent containing a hetero-atom; or two L's together with the cyclic ring to which they are attached form a fused system, n is 0, 1 or 2, m is the number of carbon atoms in the chain J. The transition metal is for example copper (II), chromium (II), manganese (II), iron (II), cobalt (II) nickel (II) or palladium (II). The aforesaid complexes may be used as catalysts in the cyclopropanation of olefins by diazoacetates to form insecticide or insecticide precursors.

Abstract translation: 手性席夫碱，其通式为：其中C *为不对称碳原子，其中R 1和R 2可以相同或不同，为烷基，芳烷基，芳基或烷芳基，R 3为氢 烷基，芳烷基，芳基或烷芳基，R 4和R 5可以相同或不同，为氢或低级烷基，或其中n为1，可以与CR4R5连接的环上形成稠合体系，J为 3或4个原子的链可以全部是碳原子，或者可以是碳原子和一个或多个可以相同或不同的杂原子的混合物，该基团与基团CK形成芳族体系，K是氮， 或者-NH-，L各自可以相同或不同，表示连接在J链上的碳原子上的取代基，是氢，烷基，芳烷基，烷芳基，芳基或含杂原子的取代基， 原子; 或两个L 3与它们所连接的环状基团一起形成稠合体系，n为0,1或2，m为链J中的碳原子数。过渡金属为例如铜（II），铬 （II），锰（II），铁（II），钴（II）镍（II）或钯（II）。 上述络合物可以用作催化剂，通过重氮乙酸酯将烯烃环丙烷化形成杀虫剂或杀虫剂前体。

公开(公告)号：US5334744A

公开(公告)日：1994-08-02

申请号：US995861

申请日：1992-12-23

Applicant: Ernest S. Cleugh ,  David J. Milner

Inventor： Ernest S. Cleugh ,  David J. Milner

IPC: C07B55/00 ,  C07B57/00 ,  C07B63/00 ,  C07C253/00 ,  C07C253/30 ,  C07C253/32 ,  C07C255/38 ,  C07C255/39 ,  C07C253/34

CPC classification number: C07C255/38

Abstract: A process for obtaining an isomer of a compound of general formulaR--CH(CN)--R' (I)wherein each of R and R' may be any organic radical linked directly or through a heteroatom to the carbon atom bearing the cyano group provided that at least one of R and R' comprises at least one resolved chiral center which is stable under the conditions of the process, or a racemic modification comprising the isomer and its enantiomer, which comprises the step of treating the epimer of the isomer, or the racemate comprising the epimer and the enantiomer of the epimer, in solution in a polar organic solvent, or in slurry in a polar organic liquid diluent in which the epimer or the racemate is partially soluble, with a source of cyanide ions, in the absence of a base, the isomer, or the racemic modification comprising the isomer and its enantiomer, being less soluble in the solvent or diluent than the epimer of the isomer, or the racemate comprising the epimer of the isomer and the enantiomer of the epimer, respectively.

Abstract translation: 获得通式为R-CH（CN）-R'（I）的化合物的异构体的方法，其中R和R'各自可以是直接或通过杂原子与带有氰基的碳原子连接的任何有机基团 条件是R和R'中的至少一个包含至少一个在该方法的条件下是稳定的拆分的手性中心，或包含异构体及其对映异构体的外消旋体，其包括处理异构体的差向异构体的步骤， 或包含差向异构体和差向异构体的对映异构体的外消旋物，在极性有机溶剂中的溶液中，或在极性有机液体稀释剂中的浆液中，其中差向异构体或外消旋体部分可溶于氰化物离子源 不含碱基，异构体或包含异构体及其对映异构体的外消旋体，比异构体的差向异构体更难溶于溶剂或稀释剂，或包含异构体的差向异构体和epim对映异构体的外消旋体 呃。

公开(公告)号：US5214161A

公开(公告)日：1993-05-25

申请号：US898833

申请日：1992-06-15

Applicant: David J. Milner

Inventor： David J. Milner

IPC: C07D307/83 ,  C07C201/12 ,  C07C205/56 ,  C07D493/04 ,  C09B57/00

CPC classification number: C07D493/04 ,  C09B57/00

Abstract: A process for the preparation of a polycyclic dye of the Formula (1): ##STR1## by reacting a ketal ester of the Formula (2): ##STR2## with a benzofuranone of the Formula (3): ##STR3## wherein: Ring A is unsubstituted or is substituted by from one to three groups:Ring B is unsubstituted, apart from the nitro group, or is substituted by one or two additional groups;each R is independently alkyl.The polycyclic dyes described are useful for the coloration of synthetic textile materials especially polyesters.

公开(公告)号：US4590308A

公开(公告)日：1986-05-20

申请号：US694161

申请日：1985-01-23

Applicant: Alan T. Costello ,  David J. Milner

Inventor： Alan T. Costello ,  David J. Milner

IPC: C07C27/00 ,  C07C29/62 ,  C07C33/46 ,  C07C67/00

CPC classification number: C07C29/62

Abstract: Process for the monohalogenation of a benzene compound which has 2 or 3 CH.sub.2 OH substituents to obtain a product wherein one of the CH.sub.2 OH substituents is monohalogenated which comprises reacting an aqueous solution of the compound with hydrochloric or hydrobromic acid in the presence of a water immiscible organic solvent which is inert to the reactants, the partition coefficient of the compound in the aqueous/organic phases being greater, with respect to the aqueous phase, than the partition coefficient of the product. The novel compounds4-chloromethyl-2,3,5,6-tetrafluorobenzene methanol and4-bromomethyl-2,3,5,6-tetrafluorobenzene methanol are also disclosed.

Abstract translation: 具有2或3个CH 2 OH取代基的苯化合物的单卤化方法，以获得其中一个CH 2 OH取代基被单卤代的产物，其中包括使化合物的水溶液与盐酸或氢溴酸在水不混溶的有机溶剂存在下反应 对反应物是惰性的，化合物在水相/有机相中的分配系数相对于水相比分配系数大。 还公开了新化合物4-氯甲基-2,3,5,6-四氟苯甲醇和4-溴甲基-2,3,5,6-四氟苯甲醇。