公开(公告)号：US07298812B2

公开(公告)日：2007-11-20

申请号：US11278287

申请日：2006-03-31

申请人： J. Eric Tkaczyk ,  William Macomber Leue ,  Walter Irving Garms ,  Joseph Bendahan ,  Deborah Walter ,  Sussan Pourjavid-Granfors ,  Xiaoye Wu ,  Peter Michael Edic ,  Pierfrancesco Landolfi

发明人： J. Eric Tkaczyk ,  William Macomber Leue ,  Walter Irving Garms ,  Joseph Bendahan ,  Deborah Walter ,  Sussan Pourjavid-Granfors ,  Xiaoye Wu ,  Peter Michael Edic ,  Pierfrancesco Landolfi

IPC分类号： G01N23/00

CPC分类号： A61B6/405 ,  A61B6/027 ,  A61B6/032 ,  A61B6/4035 ,  A61B6/4241 ,  A61B6/482 ,  G01V5/0041 ,  G01V5/005 ,  G06T11/005

摘要： A CT scanner acquires CT images at different energy levels and registers those images to provide a composite image that is substantially free of beam hardening artifacts and conspicuously provides atomic information of that imaged.

摘要翻译： CT扫描仪以不同的能量级别获取CT图像并登记这些图像以提供基本上没有光束硬化假象的合成图像，并且显着地提供该成像的原子信息。

公开(公告)号：US20060109953A1

公开(公告)日：2006-05-25

申请号：US10904630

申请日：2004-11-19

申请人： Deborah Walter ,  Kelly Piacsek

发明人： Deborah Walter ,  Kelly Piacsek

IPC分类号： H05G1/60 ,  A61B6/00 ,  G01N23/00 ,  G21K1/12

CPC分类号： A61B6/405 ,  A61B6/032 ,  A61B6/4035 ,  A61B6/4042 ,  A61B6/4241 ,  A61B6/482

摘要： A method and system of CT colonography is presented that includes the acquisition of energy sensitive or energy-discriminating CT data from a colorectal region of a subject. CT data is acquired and decomposed into basis material density maps and used to differentiate and enhance contrast between tissues in the colorectal region. The invention is particularly applicable with the detection of colon polyps without cathartic preparation or insufflation of the colorectal region. The invention is further directed to the automatic detection of colon polyps.

摘要翻译： 提出了CT结肠造影的方法和系统，其包括从受试者的结肠直肠区域获取能量敏感或能量鉴别CT数据。 CT数据获取并分解为基础材料密度图，用于区分和增强结肠直肠区域组织之间的对比度。 本发明特别适用于结肠息肉的检测，无需通气制剂或结肠直肠区域的吹入。 本发明还涉及结肠息肉的自动检测。

公开(公告)号：US20050226484A1

公开(公告)日：2005-10-13

申请号：US10813758

申请日：2004-03-31

申请人： Samit Basu ,  Bruno Bernard De Man ,  Peter Edic ,  Ricardo Avila ,  James Miller ,  Colin McCulloch ,  Deborah Walter ,  Paulo Ricardo Mendonca ,  William Leue ,  Thomas Sebastian

发明人： Samit Basu ,  Bruno Bernard De Man ,  Peter Edic ,  Ricardo Avila ,  James Miller ,  Colin McCulloch ,  Deborah Walter ,  Paulo Ricardo Mendonca ,  William Leue ,  Thomas Sebastian

IPC分类号： G06K9/00

CPC分类号： G06T11/005 ,  G06T2211/421

摘要： A technique is disclosed for generating variance data and a variance map from measured projection data acquired from a tomography system. The method comprises accessing the measured projection data from the tomography system. The method further comprises generating the variance map from the measured projection data and displaying, analyzing or processing the variance map. The variance data is determined based upon a statistical model from measured image data, and may be used for image analysis, data acquisition, in computer aided diagnosis routines, and so forth.

摘要翻译： 公开了用于从断层摄影系统获取的测量投影数据产生方差数据和方差图的技术。 该方法包括从断层摄影系统访问所测量的投影数据。 该方法还包括从所测量的投影数据生成方差图并显示，分析或处理方差图。 方差数据基于来自测量图像数据的统计模型确定，并且可以用于图像分析，数据采集，计算机辅助诊断例程等。

公开(公告)号：US20070098640A1

公开(公告)日：2007-05-03

申请号：US11265686

申请日：2005-11-02

申请人： Peter Bonitatebus ,  Oskar Axelsson ,  Amit Kulkarni ,  Brian Bales ,  Deborah Walter ,  Andrew Torres ,  Chiaki Treynor

发明人： Peter Bonitatebus ,  Oskar Axelsson ,  Amit Kulkarni ,  Brian Bales ,  Deborah Walter ,  Andrew Torres ,  Chiaki Treynor

IPC分类号： A61K49/04

CPC分类号： C09C1/00 ,  A61K49/0423 ,  B82Y5/00 ,  B82Y30/00 ,  C01G27/02 ,  C01P2004/04 ,  C01P2004/64 ,  C09C1/24 ,  C09C3/08 ,  C09C3/12

摘要： The present invention is generally directed to core/shell nanoparticles, wherein such core/shell nanoparticles comprise a nanoparticle core and a nanoshell disposed about the nanoparticle core such that, in the aggregate, they form a core/shell nanoparticle that is operable for use as an imaging agent in X-ray/computed tomography (CT). Typically, such core/shell nanoparticle-based X-ray CT imaging agents further comprise a targeting species for targeting the imaging agent to diseased sites.

摘要翻译： 本发明通常涉及核/壳纳米颗粒，其中这种核/壳纳米颗粒包含纳米颗粒核和纳米壳，该纳米壳围绕纳米颗粒核设置，使得在聚集体中，它们形成核/壳纳米颗粒，其可操作地用作 X射线/计算机断层摄影（CT）中的成像剂。 通常，这种基于核/壳纳米颗粒的X射线CT成像剂还包含用于将成像剂靶向患病部位的靶向物种。

公开(公告)号：US20070041490A1

公开(公告)日：2007-02-22

申请号：US11205556

申请日：2005-08-17

申请人： Sanjay Jha ,  Souma Sengupta ,  Deborah Walter

发明人： Sanjay Jha ,  Souma Sengupta ,  Deborah Walter

IPC分类号： A61B6/00 ,  G01N23/00 ,  G21K1/12 ,  H05G1/60

CPC分类号： A61B6/405 ,  A61B6/032 ,  A61B6/4035 ,  A61B6/4241 ,  A61B6/482 ,  A61B6/503 ,  A61B6/504 ,  A61B6/541

摘要： A method for reducing mis-registration during multiple energy scanning on computed tomographic (CT) imaging systems or multiple energy electron beam tomographic (EBT) systems includes scanning a portion of a patient including a cyclically moving body part using a multiple energy computed tomographic (CT) imaging system or multiple energy electron beam tomographic (EBT) system having at least two different energies, monitoring the cyclically moving body part, and gating the multiple energy CT imaging system or multiple energy EBT system in accordance with the monitored cyclically moving body part so that acquisitions are acquired at at least two different kVps. The data acquired at the different kVps are then utilized to generate material decomposition images of the cyclically moving body part.

公开(公告)号：US20050180542A1

公开(公告)日：2005-08-18

申请号：US10779084

申请日：2004-02-17

申请人： William Leue ,  Deborah Walter

发明人： William Leue ,  Deborah Walter

IPC分类号： A61B6/00 ,  G01N23/00 ,  G01N23/04 ,  G01N23/201 ,  G01V5/00 ,  G21K1/12 ,  H05G1/60

CPC分类号： G01V5/0016 ,  G01V5/005

摘要： A system and method for ascertaining the identity of an object within an enclosed article. The system includes an acquisition subsystem with a computed tomography machine and an alternate modality subsystem. The alternate modality subsystem includes a detector mounted to a rotatable gantry. The detector may be a quadrupole resonance unit, a dual energy x-ray unit, or a backscatter x-ray unit. The acquisition subsystem analyzes an article and distinguishes regions of interest (may contain contraband) from regions of no interest (do not contain contraband). The article is then transported to the alternate modality subsystem at which the detector further analyzes just the regions of interest.

摘要翻译： 用于确定封闭物品内物体的身份的系统和方法。 该系统包括具有计算机断层摄影机和备选模态子系统的采集子系统。 替代模态子系统包括安装到可旋转机架的检测器。 检测器可以是四极共振单元，双能X射线单元或后向散射X射线单元。 收购子系统分析一篇文章，并将不感兴趣的区域（不含违禁品）区分出利益区域（可能包含违禁品）。 然后将物品运送到交替模式子系统，在该子系统处，检测器进一步分析感兴趣的区域。

公开(公告)号：US20050031075A1

公开(公告)日：2005-02-10

申请号：US10743195

申请日：2003-12-22

申请人： Forrest Hopkins ,  Peter Edic ,  Samit Basu ,  Bruno De Man ,  James Leblanc ,  Xiaoye Wu ,  Deborah Walter ,  William Ross ,  Colin Wilson ,  Ricardo Avila ,  Robert Kaucic

发明人： Forrest Hopkins ,  Peter Edic ,  Samit Basu ,  Bruno De Man ,  James Leblanc ,  Xiaoye Wu ,  Deborah Walter ,  William Ross ,  Colin Wilson ,  Ricardo Avila ,  Robert Kaucic

IPC分类号： G01V5/00 ,  G01N23/04

CPC分类号： G01V5/0016 ,  A61B6/4035 ,  A61B6/4241 ,  A61B6/482 ,  G01V5/0041 ,  G01V5/005 ,  G06F19/00

摘要： A system and method for ascertaining the identity of an object within an enclosed article. The system includes an acquisition subsystem utilizing a stationary radiation source and detector, a reconstruction subsystem, a computer-aided detection (CAD) subsystem, and a 2D/3D visualization subsystem. The detector may be an energy discriminating detector. The acquisition subsystem communicates view data to the reconstruction subsystem, which reconstructs it into image data and communicates it to the CAD subsystem. The CAD subsystem analyzes the image data to ascertain whether it contains any area of interest. Any such area of interest data is sent to the reconstruction subsystem for further reconstruction, using more rigorous algorithms and further analyzed by the CAD subsystem. Other information, such as risk variables or trace chemical detection information may be communicated to the CAD subsystem to be included in its analysis.

摘要翻译： 用于确定封闭物品内物体的身份的系统和方法。 该系统包括利用固定辐射源和检测器，重建子系统，计算机辅助检测（CAD）子系统和2D / 3D可视化子系统的采集子系统。 检测器可以是能量识别检测器。 采集子系统将视图数据传送到重建子系统，将其重建为图像数据并将其传送到CAD子系统。 CAD子系统分析图像数据，以确定它是否包含任何感兴趣的区域。 任何这样的感兴趣的数据区域被发送到重建子系统以进一步重建，使用更严格的算法并由CAD子系统进一步分析。 其他信息，例如风险变量或痕量化学检测信息可以传达给CAD子系统以包含在其分析中。

公开(公告)号：US20070237288A1

公开(公告)日：2007-10-11

申请号：US11278287

申请日：2006-03-31

申请人： J. Tkaczyk ,  William Leue ,  Walter Garms ,  Joseph Bendahan ,  Deborah Walter ,  Sussan Pourjavid-Granfors ,  Xiaoye Wu ,  Peter Edic ,  Pierfrancesco Landolfi

发明人： J. Tkaczyk ,  William Leue ,  Walter Garms ,  Joseph Bendahan ,  Deborah Walter ,  Sussan Pourjavid-Granfors ,  Xiaoye Wu ,  Peter Edic ,  Pierfrancesco Landolfi

IPC分类号： H05G1/60 ,  A61B6/00 ,  G01N23/00 ,  G21K1/12

CPC分类号： A61B6/405 ,  A61B6/027 ,  A61B6/032 ,  A61B6/4035 ,  A61B6/4241 ,  A61B6/482 ,  G01V5/0041 ,  G01V5/005 ,  G06T11/005

摘要： A CT scanner acquires CT images at different energy levels and registers those images to provide a composite image that is substantially free of beam hardening artifacts and conspicuously provides atomic information of that imaged.

摘要翻译： CT扫描仪以不同的能量级别获取CT图像并登记这些图像以提供基本上没有光束硬化假象的合成图像，并且显着地提供该成像的原子信息。

公开(公告)号：US20070098642A1

公开(公告)日：2007-05-03

申请号：US11265729

申请日：2005-11-02

申请人： Peter Bonitatebus ,  Oskar Axelsson ,  Amit Kulkarni ,  Brian Bales ,  Deborah Walter ,  Andrew Torres ,  Chiaki Treynor

发明人： Peter Bonitatebus ,  Oskar Axelsson ,  Amit Kulkarni ,  Brian Bales ,  Deborah Walter ,  Andrew Torres ,  Chiaki Treynor

IPC分类号： A61K49/04

CPC分类号： C09C1/00 ,  A61K49/0423 ,  B82Y5/00 ,  B82Y30/00 ,  C01G27/02 ,  C01P2004/04 ,  C01P2004/64 ,  C09C1/24 ,  C09C3/08 ,  C09C3/12

摘要： The present invention is generally directed to core/shell nanoparticles, wherein such core/shell nanoparticles comprise a nanoparticle core and a nanoshell disposed about the nanoparticle core such that, in the aggregate, they form a core/shell nanoparticle that is operable for use as an imaging agent in X-ray/computed tomography (CT). Typically, such core/shell nanoparticle-based X-ray CT imaging agents further comprise a targeting species for targeting the imaging agent to diseased sites.

公开(公告)号：US07209536B2

公开(公告)日：2007-04-24

申请号：US10904630

申请日：2004-11-19

申请人： Deborah Walter ,  Kelly L. Piacsek

发明人： Deborah Walter ,  Kelly L. Piacsek

IPC分类号： H05G1/60

CPC分类号： A61B6/405 ,  A61B6/032 ,  A61B6/4035 ,  A61B6/4042 ,  A61B6/4241 ,  A61B6/482

摘要： A method and system of CT colonography is presented that includes the acquisition of energy sensitive or energy-discriminating CT data from a colorectal region of a subject. CT data is acquired and decomposed into basis material density maps and used to differentiate and enhance contrast between tissues in the colorectal region. The invention is particularly applicable with the detection of colon polyps without cathartic preparation or insufflation of the colorectal region. The invention is further directed to the automatic detection of colon polyps.

摘要翻译： 提出了CT结肠造影的方法和系统，其包括从受试者的结肠直肠区域获取能量敏感或能量鉴别CT数据。 CT数据获取并分解为基础材料密度图，用于区分和增强结肠直肠区域组织之间的对比度。 本发明特别适用于结肠息肉的检测，无需通气制剂或结肠直肠区域的吹入。 本发明还涉及结肠息肉的自动检测。