公开(公告)号：US09796683B2

公开(公告)日：2017-10-24

申请号：US15167373

申请日：2016-05-27

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Mark Bock ,  Ming-Hong Hao ,  Manav Korpal ,  Vijay Kumar Nyavanandi ,  Xiaoling Puyang ,  Susanta Samajdar ,  Peter Gerard Smith ,  John Wang ,  Guo Zhu Zheng ,  Ping Zhu

IPC: A01N43/40 ,  A61K31/44 ,  C07D231/56 ,  C07D403/12 ,  C07D471/14 ,  C07D403/06 ,  C07D401/06 ,  C07D401/14

CPC classification number: C07D231/56 ,  C07D401/06 ,  C07D401/14 ,  C07D403/06 ,  C07D403/12 ,  C07D471/14

Abstract: Disclosed herein are compounds, or pharmaceutically acceptable salts thereof, and methods of using the compounds for treating breast cancer by administration to a subject in need thereof a therapeutically effective amount of the compounds or pharmaceutically acceptable salts thereof. The breast cancer may be an ER-positive breast cancer and/or the subject in need of treatment may express a mutant ER-α protein.

公开(公告)号：US09730931B2

公开(公告)日：2017-08-15

申请号：US15221018

申请日：2016-07-27

Applicant: EISAI R&D MANAGEMENT CO., LTD.

Inventor： Dominic Reynolds ,  Ming-Hong Hao ,  John Wang ,  Sudeep Prajapati ,  Takashi Satoh ,  Anand Selvaraj

IPC: A61K31/505 ,  C07D239/48 ,  C07D405/12 ,  C07D413/12 ,  A61K31/506 ,  C07C53/18 ,  C07D401/12 ,  C07D403/12 ,  A61K31/5377

CPC classification number: A61K31/505 ,  A61K31/506 ,  A61K31/5377 ,  C07C53/18 ,  C07D239/48 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12

Abstract: Provided herein are compounds of Formula I useful as FGFR4 inhibitors, as well as methods of use of the same.

公开(公告)号：US09434697B2

公开(公告)日：2016-09-06

申请号：US15000659

申请日：2016-01-19

Applicant: EISAI R&D MANAGEMENT CO., LTD.

Inventor： Dominic Reynolds ,  Ming-Hong Hao ,  John Wang ,  Sudeep Prajapati ,  Takashi Satoh ,  Anand Selvaraj

IPC: A61K31/505 ,  C07D239/48 ,  C07D401/12 ,  C07C53/18 ,  C07D403/12 ,  C07D413/12 ,  A61K31/506

CPC classification number: A61K31/505 ,  A61K31/506 ,  A61K31/5377 ,  C07C53/18 ,  C07D239/48 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12

Abstract: Provided herein are compounds of Formula I useful as FGFR4 inhibitors, as well as methods of use of the same.

Abstract translation: 本文提供了可用作FGFR4抑制剂的式I化合物，以及其用途的方法。

公开(公告)号：US20160130237A1

公开(公告)日：2016-05-12

申请号：US15000659

申请日：2016-01-19

Applicant: EISAI R&D MANAGEMENT CO., LTD.

Inventor： Dominic Reynolds ,  Ming-Hong Hao ,  John Wang ,  Sudeep Prajapati ,  Takashi Satoh ,  Anand Selvaraj

IPC: C07D239/48 ,  C07D413/12 ,  C07D403/12 ,  C07D401/12 ,  C07C53/18

CPC classification number: A61K31/505 ,  A61K31/506 ,  A61K31/5377 ,  C07C53/18 ,  C07D239/48 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12

Abstract: Provided herein are compounds of Formula I useful as FGFR4 inhibitors, as well as methods of use of the same.

Abstract translation: 本文提供了可用作FGFR4抑制剂的式I化合物，以及其用途的方法。