公开(公告)号：US07449473B2

公开(公告)日：2008-11-11

申请号：US10973167

申请日：2004-10-26

申请人： Rao Kalla ,  Elfatih Elzein ,  Tim Marquart ,  Thao Perry ,  Xiaofen Li ,  Jeff Zablocki

发明人： Rao Kalla ,  Elfatih Elzein ,  Tim Marquart ,  Thao Perry ,  Xiaofen Li ,  Jeff Zablocki

IPC分类号： C07D471/04 ,  A61K31/519 ,  A61P11/06

CPC分类号： C07D487/04

摘要： Disclosed are novel compounds that are A2B adenosine receptor antagonists having the following structure: wherein R1 and R2 are independently chosen from hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl, and optionally substituted heteroaryl, and R4 is an optionally substituted heteroaryl moiety. The compounds of the invention are useful for treating various disease states, including asthma, chronic obstructive pulmonary disorder, pulmonary inflammation, emphysema, diabetic disorders, inflammatory gastrointestinal tract disorders, immunological/inflammatory disorders, cardiovascular diseases, neurological disorders, and diseases related to angiogenesis.

摘要翻译： 公开了作为具有以下结构的A 2 B 2腺苷受体拮抗剂的新化合物：其中R 1和R 2独立地选自氢，任选地 取代的烷基，任选取代的环烷基，任选取代的芳基和任选取代的杂芳基，R 4是任选取代的杂芳基部分。 本发明的化合物可用于治疗各种疾病状态，包括哮喘，慢性阻塞性肺病，肺部炎症，肺气肿，糖尿病，炎症性胃肠道疾病，免疫/炎性疾病，心血管疾病，神经系统疾病以及与血管发生有关的疾病 。

公开(公告)号：US20070191390A1

公开(公告)日：2007-08-16

申请号：US11685398

申请日：2007-03-13

申请人： Jeff Zablocki ,  Elfatih Elzein ,  Tim Marquart

发明人： Jeff Zablocki ,  Elfatih Elzein ,  Tim Marquart

IPC分类号： A61K31/496 ,  C07D417/02

CPC分类号： C07D295/21 ,  C07D211/58 ,  C07D277/64 ,  C07D417/12

摘要： Disclosed are novel heterocyclic compounds having the structure which are useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction. The compounds are also useful in the treatment of diabetes.

摘要翻译： 公开了具有可用于治疗各种疾病状态，特别是心血管疾病如心房和室性心律失常，间歇性跛行，Prinzmetal（变体）心绞痛，稳定和不稳定心绞痛，运动诱发的心绞痛，充血性心脏的新型杂环化合物 疾病和心肌梗死。 该化合物也可用于治疗糖尿病。

公开(公告)号：US07208496B2

公开(公告)日：2007-04-24

申请号：US10862798

申请日：2004-06-07

申请人： Jeff Zablocki ,  Elfatih Elzein ,  Tim Marquart

发明人： Jeff Zablocki ,  Elfatih Elzein ,  Tim Marquart

IPC分类号： A61K31/496 ,  C07D417/12 ,  C07D417/14 ,  C07D295/088

CPC分类号： C07D295/21 ,  C07D211/58 ,  C07D277/64 ,  C07D417/12

摘要： Disclosed are novel heterocyclic compounds having the structure which are useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction. The compounds are also useful in the treatment of diabetes.

摘要翻译： 公开了具有可用于治疗各种疾病状态，特别是心血管疾病如心房和室性心律失常，间歇性跛行，Prinzmetal（变体）心绞痛，稳定和不稳定心绞痛，运动诱发的心绞痛，充血性心脏的新型杂环化合物 疾病和心肌梗死。 该化合物也可用于治疗糖尿病。

公开(公告)号：US07026321B2

公开(公告)日：2006-04-11

申请号：US10759555

申请日：2004-01-16

申请人： Robert Jiang ,  Tim Marquart ,  Jeff Zablocki ,  Elfatih Elzein ,  Venkata Palle ,  Prabha Ibrahim

发明人： Robert Jiang ,  Tim Marquart ,  Jeff Zablocki ,  Elfatih Elzein ,  Venkata Palle ,  Prabha Ibrahim

IPC分类号： A61K31/44

CPC分类号： C07D417/12 ,  C07D277/64

摘要： Disclosed are novel heterocyclic derivatives, useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction. The compounds are also useful in the treatment of diabetes.

摘要翻译： 公开了可用于治疗各种疾病状态，特别是心血管疾病如心房和室性心律失常，间歇性跛行，Prinzmetal（变体）心绞痛，稳定和不稳定型心绞痛，运动诱发的心绞痛，充血性心脏病和心肌的新型杂环衍生物 梗死。 该化合物也可用于治疗糖尿病。