公开(公告)号：US20190275013A1

公开(公告)日：2019-09-12

申请号：US16154501

申请日：2018-10-08

Applicant: Elixir Medical Corporation

Inventor： John Yan ,  Xiaoxia Zheng ,  Vinayak D. Bhat

IPC: A61K31/436 ,  A61K31/4525 ,  A61K31/439 ,  A61K9/00 ,  A61K45/06

Abstract: The present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of the formula: wherein R1, R2, R3, R5, R6, R8, M1, M2, M3, M4, M5, M6 and M7 are each independently a member selected from the group consisting of H, C1-6 alkyl, OH and C1-6 hydroxyalkyl; R4, R7 and R9 are each independently selected from the group consisting of C1-6 alkoxy and OH; R10 is a member selected from the group consisting of H, —OH, —OP(O)Me2, —O—(CH2)n—OH and —O—(CH2)m—O—(CH2)o—CH3, wherein subscripts n and m are each independently from 2 to 8 and subscript o is from 1 to 6; each of L1 and L4 are independently selected from the group consisting of: wherein each M8 is independently a member selected from the group consisting of C1-6 alkyl, OH and C1-6 hydroxyalkyl; each of L2 and L3 are independently selected from the group consisting of: and salts, hydrates, isomers, metabolites, N-oxides and prodrugs thereof.

公开(公告)号：US20170119741A1

公开(公告)日：2017-05-04

申请号：US15181284

申请日：2016-06-13

Applicant: Elixir Medical Corporation

Inventor： John Yan ,  Xiaoxia Zheng ,  Vinayak D. Bhat

IPC: A61K31/436 ,  A61K45/06 ,  A61K9/00

CPC classification number: A61K31/436 ,  A61K9/0004 ,  A61K31/439 ,  A61K31/4525 ,  A61K45/06

Abstract: The present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of the formula: wherein R1, R2, R3, R5, R6, R8, M1, M2, M3, M4, M5, M6 and M7 are each independently a member selected from the group consisting of H, C1-6 alkyl, OH and C1-6 hydroxyalkyl; R4, R7 and R9 are each independently selected from the group consisting of C1-6 alkoxy and OH; R10 is a member selected from the group consisting of H, —OH, —OP(O)Me2, —O—(CH2)n—OH and —O—(CH2)m—O—(CH2)o—CH3, wherein subscripts n and m are each independently from 2 to 8 and subscript o is from 1 to 6; each of L1 and L4 are independently selected from the group consisting of: wherein each M8 is independently a member selected from the group consisting of C1-6 alkyl, OH and C1-6 hydroxyalkyl; each of L2 and L3 are independently selected from the group consisting of: and salts, hydrates, isomers, metabolites, N-oxides and prodrugs thereof.