公开(公告)号：USD448848S1

公开(公告)日：2001-10-02

申请号：US29121352

申请日：2000-04-05

申请人： Raymond D. Clark ,  Lonnie Hutson ,  Leonard Hoffstetter

设计人： Raymond D. Clark ,  Lonnie Hutson ,  Leonard Hoffstetter

公开(公告)号：US4212973A

公开(公告)日：1980-07-15

申请号：US062649

申请日：1979-08-01

申请人： Raymond D. Clark

发明人： Raymond D. Clark

IPC分类号： C07C53/134 ,  C07D221/20 ,  C07D211/58

CPC分类号： C07D221/20 ,  C07C53/134

摘要： Disclosed is a process comprising reacting the reaction product of cyclopentanone and methyl cyanoacetate with cyanoacetamide and/or the reaction product of cyclopentanone and cyanoacetamide with methyl cyanoacetate, in the presence of a basic catalyst, to give the intermediate .beta.,.beta.-tetramethylene-.alpha.,.alpha.'-dicyanoglutarimide, or its salt. In the process, the said reaction products may be formed together in the same reaction system, and the said intermediate preparation preferably is carried out between about 10.degree. C. and about 50.degree. C., in a polar, aprotic solvent, and in the presence of a basic catalyst, e.g., such as triethylamine. The intermediate may then be hydrolyzed to the cyclopentane-1,1-diacetic acid.

摘要翻译： 公开了一种方法，其包括使环戊酮和氰基乙酸甲酯与氰基乙酰胺和/或环戊酮和氰基乙酰胺的反应产物与氰基乙酸甲酯在碱性催化剂存在下反应，得到中间体β，β-四亚甲基-α， α'-二氰基戊二酰亚胺或其盐。 在该方法中，所述反应产物可以在相同的反应体系中一起形成，所述中间体制剂优选在极性非质子溶剂中在约10℃至约50℃之间进行，并且在 存在碱性催化剂，例如三乙胺。 然后将中间体水解成环戊烷-1,1-二乙酸。