公开(公告)号：US20170042810A1

公开(公告)日：2017-02-16

申请号：US15335640

申请日：2016-10-27

Applicant: FUJIFILM Corporation

Inventor： Takeshi MATSUMOTO ,  Kohei ONO ,  Makoto ONO ,  Kyoko SENGA

IPC: A61K9/127 ,  A61K31/519 ,  A61K31/7068

CPC classification number: A61K9/127 ,  A61K9/1278 ,  A61K31/519 ,  A61K31/7068 ,  A61K45/00 ,  A61K47/24 ,  A61K47/28

Abstract: Provided are a liposome composition which has a practically required long-term preservation stability, and which has a release rate of a drug on the order of several tens of hours due to releasability of a drug being able to be suitably controlled by rendering an inner water phase hyper-osmotic; and a method for producing the same. According to the present invention, it is possible to provide a liposome composition, including liposomes each of which has an inner water phase and an aqueous solution which constitutes an outer water phase and in which the liposomes are dispersed, in which each of the liposomes encapsulates a drug in a dissolved state, an osmotic pressure of the inner water phase is 2-fold to 8-fold relative to the osmotic pressure of the outer water phase, and a release rate of the drug from each of the liposomes is 10%/24 hr to 70%/24 hr in blood plasma at 37° C.; and a method for producing the same.

Abstract translation: 本发明提供一种脂质体组合物，其具有实际上所需的长期保存稳定性，并且由于能够通过使内部水分适当地控制药物的释放性，其具有几十小时数量级的药物的释放速率 相超渗透 及其制造方法。 根据本发明，可以提供一种脂质体组合物，其包括脂质体，其各自具有构成外部水相的内部水相和水溶液，并且其中分散有脂质体，其中每个脂质体包封 处于溶解状态的药物，内部水相的渗透压相对于外部水相的渗透压为2倍〜8倍，并且来自各脂质体的药物的释放速度为10％/ 24小时至70％/ 24小时在37℃的血浆中。 及其制造方法。