公开(公告)号：US20140270300A1

公开(公告)日：2014-09-18

申请号：US14291483

申请日：2014-05-30

申请人： Florent Michel ,  Raphael Michel ,  Daniel Shen

发明人： Florent Michel ,  Raphael Michel ,  Daniel Shen

IPC分类号： H04R25/00

CPC分类号： H04R25/00 ,  H04R25/60 ,  H04R25/70 ,  H04R2225/023 ,  H04R2460/17

摘要： An apparatus for insertion, positioning and removal of an in-ear-canal hearing aid, comprising a resilient handle, an elongated support member configured to fit into an ear canal, the support member having a first end that is configured to engage the handle and a second end that includes magnetic engagement means configured to removably engage an in-ear-canal hearing aid, and an ear canal ingression stop that is configured to limit travel of the support member and, thereby, the in-ear-canal hearing aid when engaged thereto in the ear canal.

摘要翻译： 一种用于插入，定位和移除耳内助听器的装置，包括弹性手柄，构造成装配到耳道中的细长支撑构件，所述支撑构件具有构造成接合手柄的第一端和 包括被配置为可移除地接合耳内助听器的磁性接合装置的第二端和被配置为限制支撑构件的行进的耳道入口止挡件，从而限制耳道内助听器 与耳道接合。

公开(公告)号：US20130266168A1

公开(公告)日：2013-10-10

申请号：US13865717

申请日：2013-04-18

申请人： Florent Michel ,  Raphael Michel ,  Daniel Shen

发明人： Florent Michel ,  Raphael Michel ,  Daniel Shen

IPC分类号： H04R25/02

CPC分类号： H04R25/656 ,  H04R1/42 ,  H04R25/02 ,  H04R25/456 ,  H04R25/48 ,  H04R25/604 ,  H04R25/606 ,  H04R25/652 ,  H04R25/658 ,  H04R2225/023 ,  H04R2460/09 ,  H04R2460/11 ,  H04R2460/13 ,  H04R2460/17

摘要： The invention provides systems and methods for providing hearing aid. An open ear canal hearing aid may be provided in accordance with an embodiment of the invention. The hearing aid may include a part that contains electronic components, a passive amplifier, and a securing mechanism. The securing mechanism may include bristles or balloons. The securing mechanism may have various configurations and be adjustable.

公开(公告)号：US20200253504A1

公开(公告)日：2020-08-13

申请号：US16758494

申请日：2017-11-01

申请人： Daniel Shen ,  Brett Herscher ,  David Krawzsenek ,  Kyler Connelly ,  Michael Baker ,  R. Maxwell Flaherty ,  J. Christopher Flaherty

发明人： Daniel Shen ,  Brett Herscher ,  David Krawzsenek ,  Kyler Connelly ,  Michael Baker ,  R. Maxwell Flaherty ,  J. Christopher Flaherty

IPC分类号： A61B5/053 ,  A61B5/01 ,  A61B5/00

摘要： Systems for characterizing tissue comprise: a tissue probe comprising a plurality of probe electrodes; a signal generator, a controller, and a user interface. The signal generator is in communication with the probe electrodes for delivering a drive signal to at least one probe electrode. The controller receives a recorded signal from one or more probe electrodes, the recorded signal resulting from delivery of the drive signal through tissue proximate the plurality of probe electrodes. The controller is configured to determine patient-to-patient differences when the tissue probe is proximate a known type of patient tissue and/or bodily fluid, and it produces tissue characterization information based on the recorded signal and the patient-to-patient differences. The user interface provides the tissue characterization information to an operator of the system. Methods of characterizing tissue are also provided.

公开(公告)号：US20060004191A1

公开(公告)日：2006-01-05

申请号：US10519183

申请日：2003-06-25

申请人： Sissy Jhiang ,  Daniel Shen ,  Xiaoqin Lin

发明人： Sissy Jhiang ,  Daniel Shen ,  Xiaoqin Lin

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C07K14/705

CPC分类号： C07K14/705

摘要： The invention provides modified sodium iodide symporter (NIS) proteins, and polynucleotides encoding modified NIS proteins. The modified NIS proteins have a net electrostatic charge more positive than that of corresponding wild-type NIS proteins. Expression of a modified NIS protein in a cell results in higher intracellular concentrations of NIS substrates as compared to equivalent expression of the corresponding wild-type NIS protein in a cell. The invention also provides methods for imaging cells or for therapy of cancer cells, using the modified NIS proteins to facilitate transport of NIS substrates into cells in the body of an individual. Uptake of NIS substrates suitable for either imaging or that have cytotoxic activity, into the cells of the individual that express modified NIS protein facilitate detection of the substrate (for imaging) or killing of the cancer cells (for therapy).

摘要翻译： 本发明提供修饰的碘化钠同向转运体（NIS）蛋白质和编码修饰的NIS蛋白质的多核苷酸。 修饰的NIS蛋白具有比相应的野生型NIS蛋白更纯正的净静电电荷。 与细胞中相应的野生型NIS蛋白的等同表达相比，修饰的NIS蛋白在细胞中的表达导致更高的NIS底物的细胞内浓度。 本发明还提供了用于成像细胞或用于治疗癌细胞的方法，其使用经修饰的NIS蛋白促进NIS底物输送到个体体内的细胞中。 适用于成像或具有细胞毒活性的NIS底物摄取到表达修饰的NIS蛋白的个体的细胞中有助于检测底物（用于成像）或杀死癌细胞（用于治疗）。