公开(公告)号：US20210246143A1

公开(公告)日：2021-08-12

申请号：US17239364

申请日：2021-04-23

Applicant: FORMA Therapeutics, Inc.

Inventor： Anna ERICSSON ,  Neal GREEN ,  Gary GUSTAFSON ,  Bingsong HAN ,  David R. LANCIA, JR. ,  Lorna MITCHELL ,  David RICHARD ,  Tatiana SHELEKHIN ,  Chase C. SMITH ,  Zhongguo WANG ,  Xiaozhang ZHENG

IPC: C07D487/04 ,  C07D519/00 ,  A61P7/00 ,  A61K9/00 ,  A61K31/407

Abstract: The disclosure relates to modulating pyruvate kinase and provides novel chemical compounds useful as activators of PKR, as well as various uses of these compounds. PKR activating compounds are useful in the treatment of diseases and disorders associated with PKR and/or PKM2, such as pyruvate kinase deficiency (PKD), sickle cell disease (SCD), and thalassemia.

公开(公告)号：US20200069643A1

公开(公告)日：2020-03-05

申请号：US16496279

申请日：2018-03-20

Applicant: FORMA Therapeutics, Inc.

Inventor： Anna ERICSSON ,  Neal GREEN ,  Gary GUSTAFSON ,  Bingsong HAN ,  David R. LANCIA, Jr. ,  Lorna MITCHELL ,  David RICHARD ,  Tatiana SHELEKHIN ,  Chase C. SMITH ,  Zhongguo WANG ,  Xiaozhang ZHENG

IPC: A61K31/407

Abstract: The disclosure relates to modulating pyruvate kinase and provides novel chemical compounds of formula (I) useful as activators of PKR, as well as various uses of these compounds. PKR activating compounds are useful in the treatment of diseases and disorders associated with PKR and/or PKM2, such as pyruvate kinase deficiency (PKD), sickle cell disease (SCD), and thalassemia.