公开(公告)号：US20150004611A1

公开(公告)日：2015-01-01

申请号：US13929976

申请日：2013-06-28

Applicant: General Electric Company

Inventor： Anthony John Murray ,  John Richard Nelson

IPC: C12P19/34

CPC classification number: C12P19/34 ,  C12N15/111 ,  C12N15/115 ,  C12N2310/16 ,  C12N2320/10

Abstract: Methods for developing a binding-element are provided. A mixture comprising a target molecule, a plurality of oligonucleotides and a ligase is provided, followed by binding the oligonucleotides to the target molecule to form an oligonucleotides-target molecule complex. The oligonucleotides bound to the target molecule are ligated to form the binding-element. The binding-elements are separated from the mixture.

Abstract translation: 提供了开发结合元件的方法。 提供包含靶分子，多个寡核苷酸和连接酶的混合物，然后将寡核苷酸与靶分子结合以形成寡核苷酸 - 靶分子复合物。 与靶分子结合的寡核苷酸被连接以形成结合元件。 结合元件与混合物分离。