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公开(公告)号：US20200079866A1
公开(公告)日：2020-03-12
申请号：US16582534
申请日：2019-09-25
Applicant: BIONTECH SE , GENMAB A/S
Inventor： Ugur Sahin , Friederike Gieseke , Isil Altintas , David Satijn , Paul Parren
IPC: C07K16/28
Abstract: The present invention relates to binding agents binding to receptors of the TNF superfamily, in particular binding agents binding to at least two different receptors of the TNF superfamily, as well as to their use in medicine. The present invention further relates to nucleic acid molecules encoding such binding agents, to cells comprising such nucleic acid molecules and to pharmaceutical compositions and kits.
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公开(公告)号：US11814411B2
公开(公告)日：2023-11-14
申请号：US17144591
申请日：2021-01-08
Applicant: BIONTECH SE , GENMAB A/S
Inventor： Ugur Sahin , Friederike Gieseke , Isil Altintas , David Satijn , Paul Parren
IPC: C07K16/28
CPC classification number: C07K16/2878 , C07K2317/31 , C07K2317/565 , C07K2317/75 , C07K2317/92
Abstract: The present invention relates to binding agents binding to receptors of the TNF superfamily, in particular binding agents binding to at least two different receptors of the TNF superfamily, as well as to their use in medicine. The present invention further relates to nucleic acid molecules encoding such binding agents, to cells comprising such nucleic acid molecules and to pharmaceutical compositions and kits.
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公开(公告)号：US20240254249A1
公开(公告)日：2024-08-01
申请号：US18481578
申请日：2023-10-05
Applicant: BIONTECH SE , GENMAB A/S
Inventor： Ugur Sahin , Friederike Gieseke , Isil Altintas , David Satijn , Paul Parren
IPC: C07K16/28
CPC classification number: C07K16/2878 , C07K2317/31 , C07K2317/565 , C07K2317/75 , C07K2317/92
Abstract: The present invention relates to binding agents binding to receptors of the TNF superfamily, in particular binding agents binding to at least two different receptors of the TNF superfamily, as well as to their use in medicine. The present invention further relates to nucleic acid molecules encoding such binding agents, to cells comprising such nucleic acid molecules and to pharmaceutical compositions and kits.
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14.发明授权公开(公告)号：US11932693B2
公开(公告)日：2024-03-19
申请号：US18315686
申请日：2023-05-11
Applicant: BioNTech SE , Genmab A/S
Inventor： Ugur Sahin , Sina Fellermeier-Kopf , Friederike Gieseke , Karsten Beckmann , Claudia Paulmann , Alexander Muik , Ivan Kuzmanov , Esther Cornelia Wilhelmina Breij , Patricia Garrido Castro , Jordan Blum , Lars Guelen , Joost Neijssen , Bart-Jan De Kreuk , Richard Hibbert , Janine Schuurman , Aran Frank Labrijn
IPC: C07K16/28
CPC classification number: C07K16/2818 , C07K2317/24 , C07K2317/92
Abstract: The present disclosure relates to antibodies having the ability to bind to the immune checkpoint protein programmed death-1 (PD-1), such as human PD-1, or nucleic acids encoding such antibodies, wherein the antibodies comprise modifications in the Fc region eliminating or reducing a Fc-mediated effector function of the antibodies. The present disclosure also relates to compositions or kits comprising said antibodies or nucleic acids, as well as to the use of these antibodies or nucleic acids or compositions in the field of medicine, preferably in the field of immunotherapy, e.g., for the treatment of cancers. The present invention further relates to methods for inducing an immune response in a subject comprising providing to the subject an antibody of the present disclosure or one or more nucleic acids encoding such an antibody, or a composition comprising said antibody or nucleic acids.
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公开(公告)号：US20210253725A1
公开(公告)日：2021-08-19
申请号：US17144591
申请日：2021-01-08
Applicant: BIONTECH SE , GENMAB A/S
Inventor： Ugur Sahin , Friederike Gieseke , Isil Altintas , David Satijn , Paul Parren
IPC: C07K16/28
Abstract: The present invention relates to binding agents binding to receptors of the TNF superfamily, in particular binding agents binding to at least two different receptors of the TNF superfamily, as well as to their use in medicine. The present invention further relates to nucleic acid molecules encoding such binding agents, to cells comprising such nucleic acid molecules and to pharmaceutical compositions and kits.
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Patent Agency Ranking
公开(公告)号：US20180194849A1
公开(公告)日：2018-07-12
申请号：US15538419
申请日：2016-01-08
Applicant: BIONTECH AG , GENMAB A/S
Inventor： Ugur Sahin , Friederike Gieseke , Isil Altintas , David Satijn , Paul Parren
IPC: C07K16/28
Abstract: The present invention relates to binding agents binding to receptors of the TNF superfamily, in particular binding agents binding to at least two different receptors of the TNF superfamily, as well as to their use in medicine. The present invention further relates to nucleic acid molecules encoding such binding agents, to cells comprising such nucleic acid molecules and to pharmaceutical compositions and kits.
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公开(公告)号：US10457735B2
公开(公告)日：2019-10-29
申请号：US15538419
申请日：2016-01-08
Applicant: BIONTECH AG , GENMAB A/S
Inventor： Ugur Sahin , Friederike Gieseke , Isil Altintas , David Satijn , Paul Parren
IPC: C07K16/28
Abstract: The present invention relates to binding agents binding to receptors of the TNF superfamily, in particular binding agents binding to at least two different receptors of the TNF superfamily, as well as to their use in medicine. The present invention further relates to nucleic acid molecules encoding such binding agents, to cells comprising such nucleic acid molecules and to pharmaceutical compositions and kits.
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18.发明授权公开(公告)号：US12270813B2
公开(公告)日：2025-04-08
申请号：US16620459
申请日：2018-06-01
Applicant: BioNTech SE
Inventor： Ugur Sahin
Abstract: The present invention relates to methods for predicting whether peptides or polypeptides comprising disease specific amino acid modifications, in particular tumor-associated neo-antigens, comprise epitopes, in particular tumor-associated neo-epitopes, which are useful for immunotherapy such as for vaccination. The methods of the invention may be used, in particular, for the provision of vaccines which are specific for a patient's tumor and, thus, in the context of personalized cancer vaccines.
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公开(公告)号：US12186387B2
公开(公告)日：2025-01-07
申请号：US18071499
申请日：2022-11-29
Applicant: BioNTech SE
Inventor： Alexander Muik , Asaf Poran , Kena Anne Swanson , Qi Yang , Hui Cai , Ugur Sahin
IPC: A61K39/215 , A61K9/127 , A61K39/145 , A61K45/06 , A61K47/26 , C12N15/86 , A61K39/00
Abstract: This disclosure relates to the field of RNA to prevent or treat coronavirus infection. In particular, the present disclosure relates to methods and agents for vaccination against coronavirus infection and inducing effective coronavirus antigen-specific immune responses such as antibody and/or T cell responses. Specifically, in one embodiment, the present disclosure relates to methods comprising administering to a subject RNA encoding a peptide or protein comprising an epitope of SARS-COV-2 spike protein (S protein) for inducing an immune response against coronavirus S protein, in particular S protein of SARS-COV-2, in the subject, i.e., vaccine RNA encoding vaccine antigen.
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20.发明授权公开(公告)号：US12153041B2
公开(公告)日：2024-11-26
申请号：US16301019
申请日：2017-05-10
Applicant: BioNTech SE , Tron-Translationale Onkologie an der Universitätsmedizin Der Johannesgutenberg-Universität Mainz
Inventor： Mathias Vormehr , Ugur Sahin , Barbara Schrörs , Martin Löwer , Sebastian Boegel
Abstract: The present invention relates to methods for predicting peptides or polypeptides such as T cell epitopes useful for immunotherapy such as for vaccination. In particular, the present invention relates to methods for predicting whether peptides or polypeptides such as tumor-associated antigens or epitopes, in particular tumor-associated neoantigens or neoepitopes, are immunogenic and, in particular, useful for immunotherapy such as for vaccination. The methods of the invention may be used, in particular, for the provision of vaccines which are specific for a patient's tumor and, thus, in the context of personalized cancer vaccines.
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