公开(公告)号：US20170233809A1

公开(公告)日：2017-08-17

申请号：US15271687

申请日：2016-09-21

Applicant: Genentech, Inc.

Inventor： Jason A. Hackney ,  Mary Keir ,  Gaik Wei Tew

IPC: C12Q1/68 ,  C07K16/28

CPC classification number: C12Q1/6883 ,  A61K2039/505 ,  C07K16/2839 ,  C07K16/2842 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/76 ,  C12Q2600/106 ,  C12Q2600/158

Abstract: Biomarkers predictive of responsiveness to integrin beta7 antagonists, including anti-beta7 integrin subunit antibodies, and methods of using such biomarkers are provided. In addition, methods of treating gastrointestinal inflammatory disorders such as inflammatory bowel diseases including ulcerative colitis and Crohn's disease are provided. Also provided are methods of using such predictive biomarkers for the treatment of inflammatory bowel diseases including ulcerative colitis and Crohn's disease.