公开(公告)号：US20180265497A1

公开(公告)日：2018-09-20

申请号：US15989008

申请日：2018-05-24

Applicant: Genentech, Inc. ,  The Regents of the University of California

Inventor： Marie-Gabrielle Braun ,  Paul Gibbons ,  Wendy Lee ,  Cuong Ly ,  Joachim Rudolph ,  Jacob Schwarz ,  Avi Ashkenazi ,  Leo Fu ,  Tommy Lai ,  Fei Wang ,  Ramsay Beveridge ,  Liang Zhao

IPC: C07D401/14 ,  A61K31/506 ,  C07D401/04 ,  C07D405/14 ,  C07D417/14 ,  C07D413/14 ,  A61K45/06

CPC classification number: C07D401/14 ,  A61K31/506 ,  A61K45/06 ,  A61P35/00 ,  C07D401/04 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14

Abstract: Described herein are pyrimidinyl-pyridyloxy-naphthyl compounds with inositol requiring enzyme 1 (IRE1) modulation activity or function having the Formula I or I′ structure: or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I or I′ compounds, as well as methods of using such IRE1 modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.