公开(公告)号：US20200262932A1

公开(公告)日：2020-08-20

申请号：US16777053

申请日：2020-01-30

Applicant: GENMAB A/S

Inventor： Aran Frank LABRIJN ,  Joyce I. MEESTERS ,  Ewald T. J. VAN DEN BREMER ,  Joost J. NEIJSSEN ,  Patrick VAN BERKEL ,  Bart DE GOEIJ ,  Tom VINK ,  Jan VAN DE WINKEL ,  Janine SCHUURMAN ,  Paul PARREN

IPC: C07K16/46 ,  G01N33/68 ,  C07K16/40 ,  C07K16/32 ,  C07K16/28 ,  C07K16/10

Abstract: Novel heterodimeric antibody-Fc-containing proteins, such as bispecific antibodies, and novel methods for producing such proteins

公开(公告)号：US20170369590A1

公开(公告)日：2017-12-28

申请号：US15599393

申请日：2017-05-18

Applicant: GENMAB A/S

Inventor： Bart DE GOEIJ ,  Patrick VAN BERKEL ,  Kristin STRUMANE ,  Aran Frank LABRIJN ,  Joost J. NEIJSSEN ,  Joyce I. MEESTERS ,  Paul PARREN ,  Janine SCHUURMAN

IPC: C07K16/32 ,  A61K45/06 ,  A61K47/68 ,  A61K39/395 ,  A61K39/00

CPC classification number: C07K16/32 ,  A61K39/395 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6855 ,  A61K47/6879 ,  A61K2039/505 ,  C07K16/1063 ,  C07K16/2809 ,  C07K16/2863 ,  C07K16/2887 ,  C07K16/468 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/30 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/41 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2317/55 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2317/94

Abstract: Bispecific antibodies which comprise antigen-binding regions binding to two different epitopes of human epidermal growth factor receptor 2 (HER2), and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and methods of preparing and using the antibodies are also disclosed.

公开(公告)号：US20170136130A1

公开(公告)日：2017-05-18

申请号：US15277626

申请日：2016-09-27

Applicant: GENMAB A/S

Inventor： David SATIJN ,  Sandra VERPLOEGEN ,  Wim BLEEKER ,  Steen LISBY ,  Jan VAN DE WINKEL ,  Patrick VAN BERKEL ,  Paul PARREN

IPC: A61K39/00 ,  C07K16/36 ,  A61K45/06

CPC classification number: C07K16/30 ,  A61K45/06 ,  A61K47/6817 ,  A61K47/6849 ,  C07K16/36 ,  C07K2317/21 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92

Abstract: Antibody drug conjugates against tissue factor. Also disclosed are pharmaceutical compositions comprising the antibodies and antibody drug conjugates, and therapeutic and diagnostic methods for using the antibodies and antibody drug conjugates.

公开(公告)号：US20160046727A1

公开(公告)日：2016-02-18

申请号：US14830336

申请日：2015-08-19

Applicant: GENMAB A/S

Inventor： Aran Frank LABRIJN ,  Joyce I. MEESTERS ,  Ewald T. J. VAN DEN BREMER ,  Joost J. NEIJSSEN ,  Patrick VAN BERKEL ,  Bart DE GOEIJ ,  Tom VINK ,  Jan VAN DE WINKEL ,  Janine SCHUURMAN ,  Paul PARREN

IPC: C07K16/40 ,  G01N33/68 ,  C07K16/28

CPC classification number: C07K16/468 ,  A61K2039/505 ,  C07K16/1063 ,  C07K16/2809 ,  C07K16/2863 ,  C07K16/2887 ,  C07K16/32 ,  C07K16/40 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/41 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2317/55 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2317/94 ,  G01N33/6854

Abstract: Novel heterodimeric antibody-Fc-containing proteins, such as bispecific antibodies, and novel methods for producing such proteins

Abstract translation: 新型异二聚抗体-Fc的蛋白质，例如双特异性抗体，以及用于产生这种蛋白质的新方法

公开(公告)号：US20220323582A1

公开(公告)日：2022-10-13

申请号：US17502774

申请日：2021-10-15

Applicant: GENMAB A/S

Inventor： Sandra VERPLOEGEN ,  Marije OVERDIJK ,  Riemke VAN DIJKHUIZEN ,  Willem Karel BLEEKER ,  Patrick VAN BERKEL ,  Paul PARREN ,  Steen LISBY

IPC: A61K39/395 ,  A61K51/10 ,  C07K16/28 ,  A61K47/68 ,  A61K31/7088 ,  A61K35/17 ,  A61K35/76 ,  A61K38/16 ,  A61K38/19 ,  A61K45/06 ,  C07K16/18

Abstract: Isolated human monoclonal antibodies which bind to human CD74 and related antibody-drug conjugates are disclosed. Pharmaceutical compositions comprising the antibodies or antibody-drug conjugates, and therapeutic and diagnostic methods for using the antibodies and/or antibody-drug conjugates, are also disclosed.

公开(公告)号：US20210324105A1

公开(公告)日：2021-10-21

申请号：US17149019

申请日：2021-01-14

Applicant: GENMAB A/S

Inventor： Bart DE GOEIJ ,  Patrick VAN BERKEL ,  Kristin STRUMANE ,  Aran Frank LABRIJN ,  Joost J. NEIJSSEN ,  Joyce I. MEESTERS ,  Paul PARREN ,  Janine SCHUURMAN

IPC: C07K16/32 ,  C07K16/28 ,  C07K16/10 ,  C07K16/46 ,  A61K47/68 ,  A61K39/395 ,  A61K45/06

Abstract: Bispecific antibodies which comprise antigen-binding regions binding to two different epitopes of human epidermal growth factor receptor 2 (HER2), and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and methods of preparing and using the antibodies are also disclosed.

公开(公告)号：US20190315880A1

公开(公告)日：2019-10-17

申请号：US16367933

申请日：2019-03-28

Applicant: GENMAB A/S

Inventor： David SATIJN ,  Sandra VERPLOEGEN ,  Wim BLEEKER ,  Steen LISBY ,  Jan VAN DE WINKEL ,  Patrick VAN BERKEL ,  Paul PARREN

IPC: C07K16/30 ,  A61K47/68 ,  C07K16/36 ,  A61K45/06

Abstract: Antibody drug conjugates against tissue factor. Also disclosed are pharmaceutical compositions comprising the antibodies and antibody drug conjugates, and therapeutic and diagnostic methods for using the antibodies and antibody drug conjugates.

公开(公告)号：US20190169298A1

公开(公告)日：2019-06-06

申请号：US16183300

申请日：2018-11-07

Applicant: GENMAB A/S

Inventor： Paul PARREN ,  Janine SCHUURMAN ,  Tom VINK ,  Willem Karel BLEEKER ,  Jan VAN DE WINKEL ,  Patrick VAN BERKEL ,  Frank BEURSKENS

IPC: C07K16/28

Abstract: The present invention provides monovalent antibodies with a long half-life when administered in vivo, methods of making such monovalent antibodies, pharmaceutical compositions comprising such antibodies, and uses of the monovalent antibodies.

公开(公告)号：US20170173151A1

公开(公告)日：2017-06-22

申请号：US15366791

申请日：2016-12-01

Applicant: GENMAB A/S

Inventor： Sandra VERPLOEGEN ,  Marije OVERDIJK ,  Riemke van DIJKHUIZEN ,  Willem Karel BLEEKER ,  Patrick VAN BERKEL ,  Paul PARREN ,  Steen LISBY

IPC: A61K39/395

CPC classification number: A61K39/39541 ,  A61K31/7088 ,  A61K35/17 ,  A61K35/76 ,  A61K38/162 ,  A61K38/19 ,  A61K39/39533 ,  A61K39/39566 ,  A61K45/06 ,  A61K47/6849 ,  A61K51/1027 ,  A61K2039/505 ,  A61K2121/00 ,  C07K16/18 ,  C07K16/2833 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/73 ,  C07K2317/77 ,  C07K2317/92

Abstract: Isolated human monoclonal antibodies which bind to human CD74 and related antibody-drug conjugates are disclosed. Pharmaceutical compositions comprising the antibodies or antibody-drug conjugates, and therapeutic and diagnostic methods for using the antibodies and/or antibody-drug conjugates, are also disclosed.