公开(公告)号：US06204853B1

公开(公告)日：2001-03-20

申请号：US09058100

申请日：1998-04-09

申请人： Harvey Ellis Cline ,  Allen Robert Tannenbaum

发明人： Harvey Ellis Cline ,  Allen Robert Tannenbaum

IPC分类号： G06K940

CPC分类号： G06K9/40 ,  G06T5/002 ,  G06T5/10 ,  G06T5/50 ,  G06T2207/10016 ,  G06T2207/20182 ,  H04N1/4092

摘要： The noise reduction system of the present invention takes into account that noise is random with little between images adjacent physically, and in sampling time. It also takes into account the fact that some sequences of images are cyclical and “wrap around” in time with the beginning closely resembling the end of the cycle. A filter was developed which would smooth noise in a direction along an edge, but will not blur across an edge. It operates by determining vectors tangential to a surface point p, at a current voxel, and projecting 4D data onto the tangential vectors. A curvature matrix B&agr;&bgr; is determined. The eigenvalues of curvature matrix B&agr;&bgr; are determined to result in three curvatures for 4 dimensions. If the sign of all of the eigenvalues is the same, the current voxel is filtered, else, it is unchanged. This filtering is repeated for a number of voxels as the current voxel within a desired region for a single iteration. Preferably, this is repeated for several iterations to result in filtered data with reduced noise and little change in detail. The filtered data may then be segmented to separate structures. The segmented structures may then be used in analysis, such as in medical diagnosis.

摘要翻译： 本发明的降噪系统考虑到物理上相邻的图像和采样时间之间的噪声几乎是随机的。 它还考虑到一些事实，即图像的一些序列是周期性的，并且在时间上“缠绕”，其开始与周期结束非常类似。 已经开发了一种滤光器，其可以沿着边缘的方向平滑噪声，但是不会在边缘上模糊。 它通过确定在当前体素上与表面点p相切的矢量并将4D数据投影到切向矢量上来操作。 确定曲率矩阵Balphabeta。 曲率矩阵Balphabeta的特征值被确定为导致4个维度的三个曲率。 如果所有特征值的符号相同，则对当前体素进行过滤，否则不变。 对于多次体素重复该过滤，作为单个迭代期望的区域内的当前体素。 优选地，这被重复进行几次迭代以产生具有降低的噪声并且具有细微变化的滤波数据。 然后可以将经滤波的数据分段以分离结构。 然后可以在分析中使用分段结构，例如在医学诊断中。

公开(公告)号：US6058218A

公开(公告)日：2000-05-02

申请号：US967654

申请日：1997-11-10

申请人： Harvey Ellis Cline

发明人： Harvey Ellis Cline

IPC分类号： A61B5/055 ,  A61B6/00 ,  G06T1/00 ,  G06T5/00 ,  G06T5/30 ,  G06K9/40

CPC分类号： A61B6/481 ,  A61B6/504 ,  G06T5/002 ,  G06T5/30 ,  G06T7/0081 ,  G06T7/0091 ,  A61B5/055 ,  G06T2207/10088 ,  G06T2207/20101 ,  G06T2207/30101

摘要： A volumetric data set having a high intensity, dominant structure, near smaller, less intense structures is smoothed and segmented to separate the dominant structure. The dominant structure is masked out to result in the smaller, less intense structures which are displayed. For example, dominant structures such as the blood pool in atria, ventricles, and the aorta of a 3D angiography data set is segmented and removed from the data set using mathematical morphology operations to result in an enhanced data set. The enhanced data set is displayed by conventional means such as a maximum intensity projection (MIP) at different views to yield images of coronary arteries.

摘要翻译： 具有高强度，主导结构，接近较小，不太强烈结构的体积数据集被平滑和分段以分离主导结构。 主导结构被掩盖，导致显示的较小，较不强烈的结构。 例如，使用数学形态学运算来分割并从数据集中去除主要结构，例如心房中的血池，脑室和3D血管造影数据集的主动脉，以产生增强的数据集。 增强数据集通过常规手段显示，例如在不同视图下的最大强度投影（MIP），以产生冠状动脉的图像。

公开(公告)号：US5817036A

公开(公告)日：1998-10-06

申请号：US803472

申请日：1997-02-20

申请人： Thomas Richard Anthony ,  Harvey Ellis Cline

发明人： Thomas Richard Anthony ,  Harvey Ellis Cline

IPC分类号： A61B18/00 ,  A61B17/00 ,  A61B17/32 ,  B06B1/02 ,  A61B17/22

CPC分类号： A61B17/320068 ,  A61B2017/00274 ,  A61B2017/320072 ,  A61B2018/00547

摘要： A system for treating a prostate includes an acoustic carrier, a phase fresnel zone in a section of the acoustic carrier, and an acoustic transducer. The phase fresnel zone is formed in the acoustic carrier adjacent a first end of the acoustic carrier and extends at least partially around the outer surface of the acoustic carrier. An acoustic transducer is coupled to a second end of the acoustic carrier. In treating the prostate, which surrounds a urethra, the acoustic carrier is inserted into the urethra and positioned so that the phase fresnel zone is situated in a region of the urethra surrounded by the prostate. Acoustic waves are transmitted into the second end of the acoustic carrier and the phase fresnel zone focuses the acoustic waves to constructively interfere at the location in the prostate. By moving the acoustic carrier, the phase fresnel zone may be moved along at least a portion of the region of the urethra surrounded by the prostate while the acoustic waves are being transmitted.

摘要翻译： 用于治疗前列腺的系统包括声载体，声载体的一部分中的相位菲涅耳区和声换能器。 相邻菲涅耳区形成在邻近声学载体的第一端的声学载体中并且至少部分地围绕声学载体的外表面延伸。 声换能器耦合到声载体的第二端。 在治疗包围尿道的前列腺时，将声学载体插入尿道并定位成使得相位菲涅耳区位于由前列腺包围的尿道的区域中。 声波被传送到声载体的第二端，相位菲涅耳区聚焦声波以建构性地干扰前列腺中的位置。 通过移动声载体，相位菲涅尔区域可以在声波被传输的同时沿着由前列腺包围的尿道的区域的至少一部分移动。

公开(公告)号：US08060348B2

公开(公告)日：2011-11-15

申请号：US11606582

申请日：2006-11-30

申请人： Harvey Ellis Cline ,  Ali Can ,  Xiaodong Tao ,  Robert John Filkins ,  Maximilian Lewis Seel ,  Michael Christopher Montalto

发明人： Harvey Ellis Cline ,  Ali Can ,  Xiaodong Tao ,  Robert John Filkins ,  Maximilian Lewis Seel ,  Michael Christopher Montalto

IPC分类号： G06F17/10

CPC分类号： G06T7/0012 ,  G06K9/0061 ,  G06T7/41 ,  G06T2207/10116 ,  G06T2207/30068

摘要： A system for analyzing tissue samples, that generally comprises, a storage device for at least temporarily storing one or more images of one or more cells, wherein the images comprise a plurality of channels; and a processor that is adapted to determine the extent to which a biomarker may have translocated from at least one subcellular region to another subcellular region; and then to generate a score corresponding to the extent of translocation.

摘要翻译： 一种用于分析组织样本的系统，其通常包括用于至少临时存储一个或多个单元的一个或多个图像的存储设备，其中所述图像包括多个通道; 以及适于确定生物标志物可能从至少一个亚细胞区域移位到另一亚细胞区域的程度的处理器; 然后产生与易位程度相对应的分数。

公开(公告)号：US06249693B1

公开(公告)日：2001-06-19

申请号：US09431953

申请日：1999-11-01

申请人： Harvey Ellis Cline ,  Siegwalt Ludke

发明人： Harvey Ellis Cline ,  Siegwalt Ludke

IPC分类号： A61B500

CPC分类号： G01R33/56 ,  G01R33/5608

摘要： An imaging system enables cardiac functioning within a particular cardiac chamber to be imaged. The system acquires imaging data that includes intensity values for four-dimensional voxels within a region of interest (ROI). A seed voxel is identified, and neighbor voxels to the seed voxel are also identified. The intensity values for each neighbor voxel are compared to a threshold to determine whether the voxel corresponds to blood or muscle tissue. For each neighbor voxel corresponding to blood, its neighbor voxels are identified and compared to the threshold, and this process is repeated until a pre-established spatial boundary is encountered or the number of new neighbor voxels indicates that processing is migrating into an adjacent cardiac chamber. At that point, the set of identified blood voxels represents a blood volume for the desired cardiac chamber. Voxels adjacent to the interior and exterior surface boundaries of the blood volume are added to the set. At that point, the set of voxels are counted into bins of cardiac phases, cardiac images for each phase are reconstructed, and parameters such as ejection fraction are calculated.

摘要翻译： 成像系统使得能够对特定心室内的心脏功能进行成像。 该系统获取包括感兴趣区域（ROI）内的四维体素的强度值的成像数据。 识别种子体素，并且还识别出种子体素的相邻体素。 将每个邻近体元的强度值与阈值进行比较，以确定体素是否对应于血液或肌肉组织。 对于对应于血液的每个邻近体素，其邻近体素被识别并与阈值进行比较，并且重复该过程直到遇到预先建立的空间边界或新邻居体素的数目表示该过程迁移到相邻心室 。 在这一点上，识别的血液体素的集合代表所需心室的血液体积。 与血液体积的内部和外部表面边界相邻的体素被添加到组中。 在这一点上，将这组体素计数到心脏相位的心脏区，重建每个阶段的心脏图像，并计算诸如射血分数的参数。

公开(公告)号：US6115048A

公开(公告)日：2000-09-05

申请号：US787526

申请日：1997-01-21

申请人： Harvey Ellis Cline ,  Siegwalt Ludke

发明人： Harvey Ellis Cline ,  Siegwalt Ludke

IPC分类号： G09G5/36 ,  G06T15/08 ,  G06T17/10 ,  G06F15/00

CPC分类号： G06T17/10

摘要： A system for displaying surfaces of volumetric data determines surface cubes by a simple method without interpolation. A central voxel is selected. The central voxel is tested against a threshold. If it is below the threshold, a different voxel is chosen as a central voxel. When one is found which is above the threshold, diagonal cubes, those at each of the corners of the central voxel, are tested against the threshold. When one is encountered with at least one voxel below the threshold, it is categorized as a surface voxel. The values of the adjacent voxels are then used to determine a vector normal to the surface at the central voxel. This is repeated for a number of central voxels to determine a surface. The surface then may be displayed. If anisotropic voxels are used, the elevation angle is converted to an effective elevation angle. The normal vectors to the surface are also adjusted to compensate for the anisotropic nature of the data. The voxels are then assumed to be isotropic being displayed with the effective elevation angle and using the adjusted surface normals.

摘要翻译： 用于显示体积数据表面的系统通过没有插值的简单方法来确定表面立方体。 选择中心体素。 中心体素针对阈值进行测试。 如果它低于阈值，则选择不同的体素作为中心体素。 当找到高于阈值的人时，针对阈值测试对角立方体，即中心体素的每个角落处的角立方体。 当遇到低于阈值的至少一个体素时，它被分类为表面体素。 然后使用相邻体素的值来确定在中心体素处垂直于表面的矢量。 对于许多中心体素重复这一点以确定表面。 然后可以显示表面。 如果使用各向异性体素，则将仰角转换为有效仰角。 还调整了表面的法向量以补偿数据的各向异性。 然后假设体素为具有有效仰角的各向同性，并使用调整的表面法线。

公开(公告)号：US08131476B2

公开(公告)日：2012-03-06

申请号：US11500028

申请日：2006-08-07

申请人： Harvey Ellis Cline ,  Ali Can

发明人： Harvey Ellis Cline ,  Ali Can

IPC分类号： G01N33/48

CPC分类号： G01N1/30 ,  G06T7/35 ,  G06T2207/30024 ,  G06T2207/30072

摘要： A system and methods for co-registering multi-channel images of a tissue micro array, comprising the steps of, providing a biological material on a substrate; applying one or more molecular probes, adapted to provide fluorescent molecular markers, to the biological material; obtaining a first digital image of the biological material and the fluorescent molecular markers; applying a morphological stain to the biological material; obtaining a second digital image of the biological material, computing information common to the first and second images; and co-registering the second image with the first image based on one or more registration metrics.

摘要翻译： 一种用于共同配准组织微阵列的多通道图像的系统和方法，包括以下步骤：在基底上提供生物材料; 将一种或多种适于提供荧光分子标记的分子探针应用于生物材料; 获得生物材料和荧光分子标记物的第一数字图像; 对生物材料施加形态染色; 获得生物材料的第二数字图像，计算第一和第二图像共同的信息; 以及基于一个或多个注册度量与所述第一图像共同配准所述第二图像。

公开(公告)号：US06793496B2

公开(公告)日：2004-09-21

申请号：US10085726

申请日：2002-02-28

申请人： Peter Michael Edic ,  Harvey Ellis Cline ,  Ahmad Nadeem Ishaque ,  Mehmet Yavuz

发明人： Peter Michael Edic ,  Harvey Ellis Cline ,  Ahmad Nadeem Ishaque ,  Mehmet Yavuz

IPC分类号： G09B2328

CPC分类号： G09B23/28 ,  G06F19/00 ,  G06T11/006 ,  G06T13/20 ,  G06T19/20 ,  G06T2210/41 ,  G06T2211/412 ,  G06T2219/2016 ,  G06T2219/2021

摘要： The present invention provides a model and a method and apparatus for utilizing the model to simulate an imaging scenario. The model is mathematically defined by analytical basis objects and/or polygonal basis objects. Preferably, the model is a model of the human heart and thorax. Polygonal basis objects are only used to define structures in the model that experience torsion, such as certain structures in the heart that experience torsion during the cardiac cycle. The manner in which the basis objects comprising the model are transformed by scaling, translation and rotation is defined for each basis object. In the case where a basis object experiences torsion, the rotation of the basis object will change as a function of the length along the axis of the basis object about which rotation is occurring. During an imaging system simulation, the model is utilized by a forward projection routine, which integrates the linear attenuation coefficients associated with the rays emitted by a simulated x-ray source and collected by a simulated detector array to obtain line integrals corresponding to forward projection data. The forward projection data is then processed to take into account the physics of the imaging technology, the x-ray source and the detector array. The processed projection data is then processed and back-projected by a reconstruction modeling routine to produce a reconstructed representation of the model of the heart as a function of time.

公开(公告)号：US06522786B1

公开(公告)日：2003-02-18

申请号：US09332393

申请日：1999-06-14

申请人： Harvey Ellis Cline

发明人： Harvey Ellis Cline

IPC分类号： G06T530

CPC分类号： G06T17/00 ,  G01R33/5608 ,  G06T5/002 ,  G06T5/30 ,  G06T2200/04 ,  G06T2207/10088 ,  G06T2207/20192 ,  G06T2207/30004

摘要： A method and apparatus for reducing noise in a three dimensional rectilinear parallelepiped data point array includes both erosion and dilation processes for each array point value. The erosion process includes the steps of determining gradients along all three axis which pass through a data point and modifying the point value as a function of the gradients to generate an updated point value. The dilation process includes the steps of using point values from the updated array, determining gradients along all three axis which pass through the point, and modifying the updated point value as a function of the gradients to generate a final and revised point value.

摘要翻译： 用于降低三维直线平行六面体平行六面体数据点阵列中的噪声的方法和装置包括针对每个阵列点值的侵蚀和扩张过程。 侵蚀过程包括以下步骤：沿着穿过数据点的所有三轴确定梯度并根据梯度修改点值以产生更新的点值。 膨胀过程包括以下步骤：使用来自更新的阵列的点值，沿着穿过该点的所有三轴确定梯度，以及根据梯度修改更新的点值以产生最终和修正的点值。

公开(公告)号：US06298148B1

公开(公告)日：2001-10-02

申请号：US09274010

申请日：1999-03-22

申请人： Harvey Ellis Cline ,  William Edward Lorensen

发明人： Harvey Ellis Cline ,  William Edward Lorensen

IPC分类号： G06K900

CPC分类号： G06T15/80 ,  G06T15/50

摘要： A patient surface is registered with a model surface based on curvature by acquiring patient range data and determining the curvature of the patient surface based on the range data. The patient surface is generated and shaded based on the curvature. A model surface is generated from image data and processed to determine the curvature of the model surface. The model surface is shaded to represent the curvature. The shaded patient surface and the shaded model surface are aligned in registration with each other by manipulating the patient surface and/or the model surface until the curvature features coincide.

摘要翻译： 基于曲率，通过获取患者范围数据并根据范围数据确定患者表面的曲率，将患者表面与模型表面对齐。 基于曲率产生和遮蔽患者表面。 从图像数据生成模型表面，并对其进行处理，以确定模型曲面的曲率。 模型表面被遮蔽以表示曲率。 阴影的患者表面和阴影模型表面通过操纵患者表面和/或模型表面而彼此对准，直到曲率特征重合。