公开(公告)号：US20050131245A1

公开(公告)日：2005-06-16

申请号：US10513370

申请日：2003-07-23

申请人： Toru Sasaki ,  Yutaka Onishi ,  Kohei Morikawa

发明人： Toru Sasaki ,  Yutaka Onishi ,  Kohei Morikawa

IPC分类号： B01J29/74 ,  C07B61/00 ,  C07C253/30 ,  C07C255/50

CPC分类号： C07C253/30 ,  C07C255/50

摘要： The invention enables reduction of catalyst in producing tetrafluorobenzonitrile by decyanation of one cyano group of tetrafluorodicyanobenzene by using a synthetic zeolite, particularly Zeolite 3A, 4A or 5A, in the reaction. Therefore, the invention provides an industrially useful process capable of producing tetrafluorobenzonitrile, a useful agrochemical and drug intermediate, by hydrogenolysis of tetrafluorodicyanobenzene to decyanate one cyano group with the use of catalyst in small amounts.

摘要翻译： 本发明可以通过在反应中使用合成沸石，特别是沸石3A，4A或5A脱卤一个氰基的四氟二氰基苯来制备四氟苄腈来制备催化剂。 因此，本发明提供了一种工业上有用的方法，其能够通过使用少量催化剂将四氟二氰基苯氢解成一个氰基，从而生产四氟苄腈，一种有用的农药和药物中间体。

公开(公告)号：US06720458B2

公开(公告)日：2004-04-13

申请号：US10235834

申请日：2002-09-06

申请人： Kohei Morikawa ,  Shunichi Fukuzumi ,  Kei Ohkubo ,  Yutaka Ohnishi

发明人： Kohei Morikawa ,  Shunichi Fukuzumi ,  Kei Ohkubo ,  Yutaka Ohnishi

IPC分类号： C07C4536

CPC分类号： B01J31/0231 ,  B01J31/006 ,  B01J31/0235 ,  B01J31/0271 ,  B01J35/004 ,  B01J2231/70 ,  C07C45/33 ,  C07C45/36 ,  C07C67/313 ,  C07C253/30 ,  C07C47/55 ,  C07C69/76 ,  C07C255/56

摘要： The present invention relates to a catalyst useful for a photooxidation reaction and also relates to a novel process for producing aldehydes, particularly aromatic aldehydes, which are useful as an intermediate for the production of agrochemical and medical preparations. The catalyst is particularly suitable for the oxidation of a methyl group difficult to oxidize. A photooxidation catalyst according to the invention is a halogenated aromatic nitrile represented by the following formula (1): (wherein X represents a chlorine atom or a fluorine atom, m represents an integer of 1 to 5, n represents an integer of 1 to 5, m+n≦6, and when n is 2 or more, Xs may be the same or different).

摘要翻译： 本发明涉及可用于光氧化反应的催化剂，还涉及一种生产醛，特别是芳族醛的新方法，其可用作生产农药和医药制剂的中间体。 该催化剂特别适用于难以氧化的甲基的氧化。根据本发明的光氧化催化剂是由下式（1）表示的卤代芳族腈:(其中X表示氯原子或氟原子，m 表示1〜5的整数，n表示1〜5的整数，m + n <= 6，n为2以上时，X可以相同也可以不同。

公开(公告)号：US06180801B2

公开(公告)日：2001-01-30

申请号：US09277941

申请日：1999-03-29

申请人： Hiroyuki Monzen ,  Hideo Miyata ,  Kimitaka Ooshiro ,  Kohei Morikawa

发明人： Hiroyuki Monzen ,  Hideo Miyata ,  Kimitaka Ooshiro ,  Kohei Morikawa

IPC分类号： C07D31102

CPC分类号： C07D311/76

摘要： The present invention intends to provide a method for producing 3-isochromanones represented by formula (II) useful as a synthetic starting material of medicals or agricultural chemicals and the cyano compound represented by formula (I) by an industrially advantageous method in a high yield. Disclosed herein is a method for manufacturing a 3-isochromanone represented by the following formula (II): (wherein R2, R3, R4 and R5 each independently represents a hydrogen atom, a halogen atom, an alkyl group or an alkoxy group), said method is characterized by comprising the steps of: hydrolyzing a cyano compound represented by formula (I): (wherein R1 represents a hydrogen atom, an alkyl group or an aryl group, and R2, R3, R4 and R5 have the same meanings as defined above) and subjecting the hydrolyzate to intra-molecular cyclization.

摘要翻译： 本发明意在提供一种由工业上有利的方法以高产率制备可用作医药或农药合成原料的式（II）表示的3-异色满酮和由式（I）表示的氰基化合物的方法。 本文公开了一种制备由下式（II）表示的3-异色满酮的方法：其中R2，R3，R4和R5各自独立地表示氢原子，卤原子，烷基或烷氧基），所述 方法的特征在于包括以下步骤：水解由式（I）表示的氰基化合物:(其中R1表示氢原子，烷基或芳基，R2，R3，R4和R5具有与定义相同的含义） 并使水解产物进行分子内环化。

公开(公告)号：US5679844A

公开(公告)日：1997-10-21

申请号：US605056

申请日：1996-03-01

申请人： Hideo Miyata ,  Toru Sasaki ,  Kohei Morikawa

发明人： Hideo Miyata ,  Toru Sasaki ,  Kohei Morikawa

IPC分类号： C07F9/38

CPC分类号： C07F9/3813

摘要： The present invention relates to a method of manufacturing N-phosphonomethylglycine and salts thereof, which can be biologically degraded, and have superior effectiveness against weeds and are useful as herbicides, by means of alkali hydrolysis of N-phosphonomethylglycinonitrile. In order to obtain high yields of the desired high purity, the amount of salt produced as a by-product is reduced by using the alkali so as to result in not less than 2 molecules and less than 3 molecules of the alkali for each molecule of N-phosphonomethylglycinonitrile when the alkali is monovalent, and not less than 1 molecule and less than 1.5 molecules of the alkali for each molecule of N-phosphonomethylglycinonitrile when the alkali is divalent.

摘要翻译： PCT No.PCT / JP95 / 01327 Sec。 371日期1996年3月1日 102（e）1996年3月1日PCT PCT 1995年7月3日PCT公布。 出版物WO96 / 01264 日期1996年1月18日本发明涉及N-膦酰基甲基甘氨酸及其盐的制造方法，其可以生物降解，并且对于杂草具有优异的有效性，并且通过N-膦酰基甲基甘氨腈的碱水解可用作除草剂。 为了获得所需高纯度的高产率，通过使用碱来降低作为副产物产生的盐的量，从而得到每个分子的不少于2个分子和少于3个碱的分子 当碱为二价时，N-膦酰基甲基甘氨腈为N-膦酰基甲基甘氨腈，当碱为二价时，每分子N-膦酰基甲基甘氨腈为1分子以上且小于1.5分子的碱。

公开(公告)号：US20070149719A1

公开(公告)日：2007-06-28

申请号：US10584150

申请日：2004-12-22

申请人： Etsuo Fujimoto ,  Akiko Shinoda ,  Kohei Morikawa

发明人： Etsuo Fujimoto ,  Akiko Shinoda ,  Kohei Morikawa

IPC分类号： C08F8/32

CPC分类号： B01J20/262 ,  B01J20/223 ,  B01J20/24 ,  B01J20/265 ,  B01J20/267 ,  B01J20/28004 ,  B01J20/28059 ,  B01J20/286 ,  B01J20/3212 ,  B01J20/3217 ,  B01J20/3242 ,  B01J20/3265 ,  B01J20/3425 ,  B01J20/3475 ,  B01J2220/4825 ,  B01J2220/49 ,  B01J2220/52 ,  B01J2220/54 ,  B01J2220/58 ,  B01J2220/62 ,  B01J2220/66 ,  B01J2220/84

摘要： This invention provides a granular polysaccharide polymer having phthalocyanine bonded thereto which is a crosslinked polymer comprising a phthalocyanine skeleton covalently bonded to a crosslinked granular porous chitosan. When this crosslinked polymer is used as an adsorbent, a polycyclic organic material present as a mixture in a solution can be selectively adsorbed, desorbed, or separated. The granular polysaccharide polymer having phthalocyanine bonded thereto is excellent not only in the ability to adsorb polycyclic organic materials, but in the ability to desorb the adsorbed polycyclic organic materials. Accordingly, the crosslinked polymer is particularly useful for selective adsorption, desorption/concentration, or separation of polycyclic organic materials, e.g., mutagens, present in a very small amount, for example, in environments, foods, table luxuries, biological samples and can be widely utilized for the qualitative determination, quantitative determination, or removal of mutagens.

摘要翻译： 本发明提供了一种结合有酞菁的粒状多糖聚合物，其是包含与交联的颗粒状多孔壳聚糖共价键合的酞菁骨架的交联聚合物。 当该交联聚合物用作吸附剂时，可以选择性地吸附，解吸或分离作为溶液中的混合物存在的多环有机材料。 具有与其结合的酞菁的粒状多糖聚合物不仅具有吸附多环有机材料的能力，而且在吸附多环有机材料的解吸能力方面优异。 因此，交联聚合物特别可用于多环有机材料的选择性吸附，解吸/浓缩或分离，例如以非常少量存在的诱变剂，例如在环境，食品，餐具，生物样品中，并且可以是 广泛用于定性测定，定量测定或除去诱变剂。

公开(公告)号：US20070106033A1

公开(公告)日：2007-05-10

申请号：US10584152

申请日：2004-12-22

申请人： Etsuo Fujimoto ,  Akiko Shinoda ,  Kohei Morikawa ,  Yoshio Fujiwara

发明人： Etsuo Fujimoto ,  Akiko Shinoda ,  Kohei Morikawa ,  Yoshio Fujiwara

IPC分类号： C08F120/10 ,  C08F220/10 ,  C08C19/22 ,  C08F20/10 ,  C08F8/32

CPC分类号： B01J20/261 ,  B01J20/223 ,  B01J20/26 ,  B01J20/264 ,  B01J20/265 ,  B01J20/267 ,  B01J20/28004 ,  B01J20/28057 ,  B01J20/285 ,  B01J20/286 ,  B01J20/3007 ,  B01J20/3042 ,  B01J20/321 ,  B01J20/3217 ,  B01J20/3242 ,  B01J20/3265 ,  B01J20/3425 ,  B01J20/3475 ,  B01J2220/49 ,  B01J2220/52 ,  B01J2220/54 ,  B01J2220/58 ,  B01J2220/62 ,  B01J2220/66 ,  B01J2220/84 ,  C08F8/30 ,  C08F8/42

摘要： This invention provides a crosslinked polymer produced by polymerizing one or more crosslinking monomers and bonding, preferably covalently bonding, a phthalocyanine skeleton to the resultant polymer. The degree of crosslinking is 1% or higher. When this crosslinked polymer is used as an adsorbent, a polycyclic organic material present as a mixture in a solution can be selectively adsorbed, desorbed, or separated. The crosslinked polymer having a phthalocyanine bonded thereto is excellent not only in the ability to adsorb polycyclic organic materials, but in the ability to desorb the adsorbed polycyclic organic materials. Accordingly, the crosslinked polymer is particularly useful for selective adsorption, desorption/concentration, or separation of polycyclic organic materials, e.g., mutagens, present in a very small amount, for example, in environments, foods, table luxuries, biological samples and can be widely utilized for the qualitative determination, quantitative determination, or removal of mutagens.

摘要翻译： 本发明提供了通过聚合一种或多种交联单体并将酞菁骨架共价键合到所得聚合物而制备的交联聚合物。 交联度为1％以上。 当该交联聚合物用作吸附剂时，可以选择性地吸附，解吸或分离作为溶液中的混合物存在的多环有机材料。 具有与其结合的酞菁的交联聚合物不仅具有吸附多环有机材料的能力，而且在吸附多环有机材料的解吸能力方面优异。 因此，交联聚合物特别可用于多环有机材料的选择性吸附，解吸/浓缩或分离，例如以非常少量存在的诱变剂，例如在环境，食品，餐具，生物样品中，并且可以是 广泛用于定性测定，定量测定或除去诱变剂。

公开(公告)号：US06624336B1

公开(公告)日：2003-09-23

申请号：US09959715

申请日：2001-11-05

申请人： Toru Sasaki ,  Tetsuhiro Furukawa ,  Toru Yoshida ,  Yutaka Ohnishi ,  Hiroyuki Monzen ,  Hideo Miyata ,  Kohei Morikawa

发明人： Toru Sasaki ,  Tetsuhiro Furukawa ,  Toru Yoshida ,  Yutaka Ohnishi ,  Hiroyuki Monzen ,  Hideo Miyata ,  Kohei Morikawa

IPC分类号： C07C3346

CPC分类号： C07C47/55 ,  B01J25/02 ,  B01J27/055 ,  C07C29/141 ,  C07C43/313 ,  C07C45/44 ,  C07C45/515 ,  C07C33/46

摘要： The present invention relates to a process by a series of reactions using tetrafluorocyanobenzens as material for producing tetrafluorobenzenemethanols, tetrafluorobenzenecarbaldehyde dialkylacetals and tetrafluorobenzenecarbaldehydes in a high purity and a high yield which are useful as intermediates in the production of cyclopropanecarboxylic acid esters having insecticidal action, and also relates to a novel tetrafluorobenzenecarbaldehyde dimethylacetal.

摘要翻译： 本发明涉及一种通过一系列反应的方法，该反应使用四氟氰基化合物作为生产具有杀虫作用的环丙烷羧酸酯的中间体而制备四氟苯甲醇，四氟苯甲醛二烷基缩醛和四氟苯甲醛的高纯度和高收率的材料， 涉及一种新的四氟苯甲醛二甲缩醛。

公开(公告)号：US5859289A

公开(公告)日：1999-01-12

申请号：US814830

申请日：1997-03-11

申请人： Hideo Miyata ,  Toru Sasaki ,  Kohei Morikawa

发明人： Hideo Miyata ,  Toru Sasaki ,  Kohei Morikawa

IPC分类号： A01N57/20 ,  C07F9/38

CPC分类号： A01N57/20 ,  C07F9/3813

摘要： The present invention provides a method for isolating N-phosphonomethylglycine which comprises adding an acid to precipitate salts from an aqueous solution of an alkali metal salt and/or an alkaline earth metal salt of N-phosphonomethylglycine solution to neutralize and adjust the same to a pH of 2.5 or higher, removing the precipitated salts, and adjusting the pH to 2.5 or lower to crystallize N-phosphonomethylglycine. N-phosphonomethylglycine is thus isolated and purified in high purity and good yield.

摘要翻译： 本发明提供了一种分离N-膦酰基甲基甘氨酸的方法，该方法包括加入酸以从N-膦酰基甲基甘氨酸溶液的碱金属盐和/或碱土金属盐的水溶液中沉淀出盐，以将其调节至pH 2.5或更高，去除沉淀的盐，并将pH调节至2.5以下以结晶N-膦酰基甲基甘氨酸。 因此N-膦酰基甲基甘氨酸以高纯度和良好的产率分离和纯化。

公开(公告)号：US5750774A

公开(公告)日：1998-05-12

申请号：US814827

申请日：1997-03-11

申请人： Hideo Miyata ,  Toru Sasaki ,  Kohei Morikawa

发明人： Hideo Miyata ,  Toru Sasaki ,  Kohei Morikawa

IPC分类号： C07F9/38

CPC分类号： C07F9/3813

摘要： The present invention provides a method for producing N-phosphonomethylglycine which comprises reacting an aminomethylphosphonic acid with glycolonitrile, or formaldehyde and hydrogen cyanide in situ, under an alkaline condition to convert the aminomethylphosphonic acid into an N-phosphonomethylglycinonitrile salt or a mixture of an N-phosphonomethylglycinonitrile salt and N-phosphonomethylglycinonitrile, and then hydrolyzing the product under an acidic condition. Subsequent to a reaction step for the production of N-phosphonomethylglycinonitrile, the reaction product is hydrolyzed by adding thereto an acid in a prescribed amount. Accordingly, the use of a large amount of an alkaline metal hydroxide and the neutralization step for obtaining N-phosphonomethylglycine after hydrolysis, which steps are necessary in a conventional alkali hydrolysis method, are omitted in the present invention.

摘要翻译： 本发明提供了一种N-膦酰基甲基甘氨酸的制备方法，该方法包括使氨基甲基膦酸与乙醇腈或甲醛和氰化氢在碱性条件下原位反应，将氨基甲基膦酸转化为N-膦酰基甲基甘氨腈盐或N- 膦酰基甲基甘氨腈盐和N-膦酰基甲基甘氨腈，然后在酸性条件下水解产物。 在制备N-膦酰基甲基甘氨腈的反应步骤之后，通过向其中加入规定量的酸来水解反应产物。 因此，在本发明中，省略了大量碱金属氢氧化物的使用和水解后得到N-膦酰基甲基甘氨酸的中和工序，这些步骤在常规碱水解法中是必需的。

公开(公告)号：US5324855A

公开(公告)日：1994-06-28

申请号：US961363

申请日：1992-10-15

申请人： Kohei Morikawa ,  Toru Sasaki ,  Kazuhiro Omori ,  Hideo Miyata ,  Yoko Suguri

发明人： Kohei Morikawa ,  Toru Sasaki ,  Kazuhiro Omori ,  Hideo Miyata ,  Yoko Suguri

IPC分类号： C07F9/24 ,  C07F9/38

CPC分类号： C07F9/3813

摘要： N-acylaminomethylphosphonic acid is prepared from an N-methylolamide compound and a phosphorus trihalide. The starting compounds are mixed and heated in an aprotic solvent in the presence of water in a 0.25 to 2.5 times molar amount relative to the phosphorus trihalide at 60.degree. to 160.degree. C., and the reaction mixture is contacted with water. The N-methylolamide compound is a compound selected from the group consisting of N-methylol-lower alkylamides and N-methylolarylamides. The phosphorus trihalide is preferably phosphorus trichloride. As the aprotic solvent is used one or more of hydrocarbons, halogenated hydrocarbons, ethers, polyethers, nitriles, and aromatic nitro compounds. The mixing may be carried out at a temperature of 60.degree. C. The water present at the initiation of the reaction is in a 1.0 to 1.8 times molar amount relative to the phosphorus trihalide.

摘要翻译： N-酰氨基甲基膦酸由N-羟甲基酰胺化合物和三卤化磷制备。 将起始化合物在非质子溶剂中在相对于三卤化磷在0.25至160℃下以0.25至2.5倍摩尔量存在的水中加热，并将反应混合物与水接触。 N-羟甲基酰胺化合物是选自N-羟甲基 - 低级烷基酰胺和N-羟甲基芳基酰胺的化合物。 三卤化磷优选为三氯化磷。 由于非质子溶剂使用一种或多种烃，卤代烃，醚，聚醚，腈和芳族硝基化合物。 混合可以在60℃的温度下进行。反应开始时存在的水相对于三卤化磷的摩尔量为1.0〜1.8倍。