公开(公告)号：US20110269781A1

公开(公告)日：2011-11-03

申请号：US13154818

申请日：2011-06-07

申请人： Linos Lazarides ,  Stephen Allan Smith ,  Richard Stocker ,  Colin Jack Theobald

发明人： Linos Lazarides ,  Stephen Allan Smith ,  Richard Stocker ,  Colin Jack Theobald

IPC分类号： A61K31/522 ,  A61P37/08

CPC分类号： C07D473/18 ,  C07D473/16

摘要： The present invention includes novel compounds useful in the treatment of various disorders in particular infectious diseases, cancer, and allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, and as vaccine adjuvants.

摘要翻译： 本发明包括可用于治疗各种疾病，特别是感染性疾病，癌症和过敏性疾病以及其它炎性病症例如过敏性鼻炎和哮喘以及作为疫苗佐剂的新型化合物。

公开(公告)号：US20100120799A1

公开(公告)日：2010-05-13

申请号：US12527820

申请日：2008-02-15

申请人： Linos Lazarides ,  Stephen Allan Smith ,  Richard Stocker ,  Colin Jack Theobald

发明人： Linos Lazarides ,  Stephen Allan Smith ,  Richard Stocker ,  Colin Jack Theobald

IPC分类号： A61K31/522 ,  C07D473/18 ,  A61P35/00 ,  A61P29/00 ,  A61P11/06

CPC分类号： C07D473/18 ,  C07D473/16

摘要： Compounds of formula (I): wherein R1 is C1-8alkylamino, C1-8alkoxy, C3-7cycloalkylC1-6alkylamino, C3-7cycloalkylC1-6alkoxy, C1-3alkoxyC2-3alkoxy, or Hetb-C1-3alkoxy; Hetb is a 5- or 6-membered saturated aliphatic heterocycle containing one oxygen atom; R2 is —(CH2)n-Het; n is an integer having a value of 1 to 4; Het is a 5- or 6-membered saturated aliphatic heterocycle containing one oxygen heteroatom, which heterocycle may be substituted by one or two C1-4alkyl groups, and salts and solvates thereof, are inducers of human interferon and may be useful in the treatment of various disorders in particular infectious diseases, cancer, and allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, and as vaccine adjuvants.

摘要翻译： 式（I）化合物：其中R 1是C 1-8烷基氨基，C 1-8烷氧基，C 3-7环烷基C 1-6烷基氨基，C 3-7环烷基C 1-6烷氧基，C 1-3烷氧基C 2-3烷氧基或Hetb-C 1-3烷氧基; Hetb是含有一个氧原子的5或6元饱和脂肪族杂环; R2是 - （CH2）n-Het; n为1〜4的整数， Het是含有一个氧杂原子的5-或6-元饱和脂族杂环，该杂环可以被一个或两个C 1-4烷基取代，其盐和溶剂化物是人类干扰素的诱导剂，可用于治疗 各种疾病，特别是传染病，癌症，过敏性疾病和其他炎性病症，例如过敏性鼻炎和哮喘，以及疫苗佐剂。

公开(公告)号：US5426089A

公开(公告)日：1995-06-20

申请号：US293600

申请日：1994-08-22

申请人： Christopher J. Foster ,  Terence Gilkerson ,  Richard Stocker

发明人： Christopher J. Foster ,  Terence Gilkerson ,  Richard Stocker

IPC分类号： A01N43/40 ,  C07D213/64 ,  C07D213/643

CPC分类号： C07D213/643 ,  A01N43/40

摘要： Herbicidal compounds ##STR1## in which Q represents a group --C(O)--C(CN).dbd.CH--NR.sup.1 R.sup.2, R.sup.1 and R.sup.2 each independently represents alkyl, or together represent alkylene optionally interrupted by oxygen, m is O or m is an integer from 1 to 3 and the or each Y independently represents halogen or alkyl and n is O or n is an integer from 1 to 5 and the or each X independently represents halogen, alkyl, haloalkyl, cyanoalkyl, alkenyl, alkynyl, alkoxy, haloalkoxy, haloalkylthio, alkenyloxy, alkynyloxy, alkylthio, alkenylthio, alkynylthio, cyano, nitro, alkylsulphonyl, alkysulphinyl, sulphonamido, or phenyl optionally substituted by alkyl, haloalkyl, alkoxy or halogen.

摘要翻译： 除草剂化合物（I）其中Q代表基团-C（O）-C（CN）= CH-NR1R2，R1和R2各自独立地表示烷基，或一起表示任选被氧中断的亚烷基，m是O或 m是1至3的整数，并且每个Y独立地表示卤素或烷基，n是0或n是1至5的整数，并且每个X独立地表示卤素，烷基，卤代烷基，氰基烷基，烯基，炔基， 烷氧基，卤代烷氧基，卤代烷硫基，烯氧基，炔氧基，烷硫基，烯硫基，炔硫基，氰基，硝基，烷基磺酰基，烷基亚磺酰基，磺酰氨基或任选被烷基，卤代烷基，烷氧基或卤素取代的苯基。

公开(公告)号：US5384305A

公开(公告)日：1995-01-24

申请号：US787647

申请日：1991-11-04

申请人： Christopher J. Foster ,  Terence Gilkerson ,  Richard Stocker ,  Ian J. Gilmore

发明人： Christopher J. Foster ,  Terence Gilkerson ,  Richard Stocker ,  Ian J. Gilmore

IPC分类号： A01N43/40 ,  A01P13/00 ,  C07D213/79 ,  C07D213/81 ,  C07D213/83 ,  C07D213/86 ,  C07D213/56

CPC分类号： C07D213/79 ,  C07D213/81 ,  C07D213/83 ,  C07D213/86

摘要： Compounds of the formula ##STR1## wherein n is 1 to 5 and the/each X is hydrogen, halogen, cyano, nitro, optionally substituted alkyl or alkoxy alkenyloxy, alkynyloxy, haloalkylthio, alkenylthio or alkynylthio;m is 0 or 1 to 3 and the/each Y is halogen, alkyl or haloalkyl;Z is oxygen or sulphur;andR.sup.1 and R.sup.2 each, independently, is hydrogen, alkyl optionally substituted by halogen, hydroxy, cyano, alkoxy, alkylthio, alkoxycarbonyl, or mono- or di-alkylamino, alkenyl, alkynyl, hydroxy, alkoxy, alkenyloxy, alkynyloxy, alkoxycarbonyl, amino, mono- or di-alkylamino, alkoxycarbonylamino, arylamino, dialkylcarbamoyl, cycloalkyl, or optionally substituted cycloalkylalkyl;orR.sup.1 and R.sup.2 together form an alkylene chain optionally interrupted by oxygen, sulphur or --NR--, R being hydrogen or alkyl;are herbicides.

摘要翻译： 式（I）的化合物，其中n为1至5，并且每个X为氢，卤素，氰基，硝基，任选取代的烷基或烷氧基烯氧基，炔氧基，卤代烷硫基，烯硫基或炔硫基; m为0或1至3，并且每个Y为卤素，烷基或卤代烷基; Z是氧或硫; 羟基，氰基，烷氧基，烷硫基，烷氧基羰基或单 - 或二 - 烷基氨基，烯基，炔基，羟基，烷氧基，烯氧基，炔氧基，烷氧基羰基，氨基 ，单 - 或二 - 烷基氨基，烷氧基羰基氨基，芳基氨基，二烷基氨基甲酰基，环烷基或任选取代的环烷基烷基; 或R 1和R 2一起形成任选被氧，硫或-NR-中断的亚烷基链，R是氢或烷基; 是除草剂。

公开(公告)号：US5294597A

公开(公告)日：1994-03-15

申请号：US663722

申请日：1991-03-04

申请人： Christopher J. Foster ,  Terence Gilkerson ,  Richard Stocker

发明人： Christopher J. Foster ,  Terence Gilkerson ,  Richard Stocker

IPC分类号： A01N43/40 ,  A01P13/00 ,  C07D213/78 ,  C07D213/79 ,  C07D213/81 ,  C07D213/83 ,  C07D213/64

CPC分类号： C07D213/79 ,  A01N43/40 ,  C07D213/78 ,  C07D213/81

摘要： Compounds of formula ##STR1## wherein Z is oxygen or sulphur;R.sup.1 is hydrogen, halogen, alkyl or haloalkyl;R.sup.2 is hydrogen, or alkyl;q is 0 or 1;R.sup.3 is hydrogen, alkyl or alkenyl; the or each X independently is halogen, optionally substituted alkyl or alkoxy, alkenyloxy, alkynyloxy, cyano, carboxy, alkoxycarbonyl, (alkylthio)carbonyl, alkylcarbonyl, amido, alkylamido, nitro, alkylthio, haloalkylthio, alkenylthio, alkynylthio, alkylsulphinyl, alkylsulphonyl, alkyloximinoalkyl or alkenyloximinoalkyl;n is 0 or an integer from 1 to 5; the or each Y independently is a halogen, alkyl, nitro, cyano, haloalkyl, alkoxy or haloalkoxy; and m is 0 or an integer from 1 to 5, their preparation and use as herbicides.

摘要翻译： 式（*化学结构*）（I）的化合物，其中Z是氧或硫; R1是氢，卤素，烷基或卤代烷基; R2是氢或烷基; q为0或1; R3是氢，烷基或烯基; 氰基，羧基，烷氧基羰基，（烷硫基）羰基，烷基羰基，酰胺基，烷基酰氨基，硝基，烷硫基，卤代烷硫基，烯硫基，炔硫基，烷基亚磺酰基，烷基磺酰基，烷氧基亚氨基烷基 或烯氧肟基烷基; n为0或1〜5的整数; 该或每个Y独立地是卤素，烷基，硝基，氰基，卤代烷基，烷氧基或卤代烷氧基; m为0或1〜5的整数，它们的制备和用作除草剂。