公开(公告)号：US5218138A

公开(公告)日：1993-06-08

申请号：US939273

申请日：1992-09-02

申请人： Fang-Ting Chiu ,  William L. Studt

发明人： Fang-Ting Chiu ,  William L. Studt

IPC分类号： C07C69/732

CPC分类号： C07C69/732

摘要： This invention is directed to a method for stereoselectively preparing a syn-dihydroxylated compound comprising reacting a 3-hydroxyket-1-one and a sterically hindered dialkylated borane to form a complex at about -50.degree. C. to about 0.degree. C., and reducing the complex with hydride at about -25.degree. C. to about 50.degree. C.

摘要翻译： 本发明涉及立体选择性制备顺式二羟基化合物的方法，包括使3-羟基酮-1-酮和空间位阻二烷基化硼烷在约-50℃至约0℃下反应形成络合物，和 在约-25℃至约50℃下将氢化物络合物还原

公开(公告)号：US4681889A

公开(公告)日：1987-07-21

申请号：US879689

申请日：1986-06-27

申请人： Robin Clark ,  Joseph M. Muchowski ,  Fang-Ting Chiu ,  John O. Gardner ,  Jacob Berger

发明人： Robin Clark ,  Joseph M. Muchowski ,  Fang-Ting Chiu ,  John O. Gardner ,  Jacob Berger

IPC分类号： C07D217/20 ,  C07D405/06 ,  A61K31/47

CPC分类号： C07D405/06 ,  C07D217/20

摘要： Compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2 are each independently --H or lower alkoxy;R.sub.3 and R.sub.4 are each independently lower alkyl; andR.sub.5 and R.sub.6 are each --OCH.sub.3, or together form --OCH.sub.2 O-- or --OCH.sub.2 CH.sub.2 O--and pharmaceutically acceptable acid addition salts thereof are calcium channel blockers useful for treating cardiovascular disorders including angina, hypertension and congestive heart failure.

摘要翻译： 式（1）的化合物其中R 1和R 2各自独立地为-H或低级烷氧基; R3和R4各自独立地为低级烷基; 并且R 5和R 6各自为-OCH 3，或一起形成-OCH 2 O-或-OCH 2 CH 2 O-，及其药学上可接受的酸加成盐是可用于治疗包括心绞痛，高血压和充血性心力衰竭的心血管疾病的钙通道阻滞剂。

公开(公告)号：US08080674B2

公开(公告)日：2011-12-20

申请号：US12483918

申请日：2009-06-12

申请人： Fang-Ting Chiu

发明人： Fang-Ting Chiu

IPC分类号： C07D339/00 ,  C07D409/00

CPC分类号： C07D339/04 ,  C07D339/08

摘要： R-α-Lipoic acid and its homologs are converted to their magnesium salts in the presence of a reduced form of the acid, dihydro-(+)-lipoic acid in the case of R-α-lipoic acid itself. The reduced form serves as a polymerization inhibitor, resulting in a Mg di-R-α-lipoate product of higher purity. The reduced acid retained in the product tends to convert to the starting acid, thereby avoiding the inclusion of an extraneous polymerization inhibitor in the product.

摘要翻译： 在R-α-硫辛酸本身的情况下，在还原形式的二氢 - （+） - 硫辛酸存在下，将R-α-硫辛酸及其同系物转化为其镁盐。 还原形式用作阻聚剂，得到更高纯度的Mg二-R-α-脂肪酸酯产物。 产物中残留的还原酸倾向于转化为起始酸，从而避免在产物中包含外来阻聚剂。

公开(公告)号：US06469170B1

公开(公告)日：2002-10-22

申请号：US10152140

申请日：2002-05-21

申请人： Fang-Ting Chiu ,  Young S. Lo

发明人： Fang-Ting Chiu ,  Young S. Lo

IPC分类号： C07D47100

CPC分类号： C07D489/06

摘要： A method for the preparation of oxycodone, and salts thereof, from codeine comprising oxidation of codeine to codeinone, formation of an dienolsilyl ether congener of codeinone in strong amine base, oxidation of the dienolsilyl ether congener using peracetic acid, and hydrogenation of the resulting 14-hydroxycodeinone product.