公开(公告)号：US20230235410A1

公开(公告)日：2023-07-27

申请号：US18089565

申请日：2022-12-28

Applicant: Industrial Technology Research Institute

Inventor： Jian-Hao Li ,  Hui-Chu Hsieh ,  Po-Chang Chen ,  Pei-Shin Jiang ,  Chih-Lung Lin

IPC: C12Q1/6886

CPC classification number: C12Q1/6886 ,  C12Q2600/158

Abstract: An identification system of circulating biomarkers for cancer detection, a development method of circulating biomarkers for cancer detection, a cancer detection method and a kit are provided in the present disclosure, and the development method includes the following steps. Expression levels of multiple genes in normal tissue samples and tumor tissue samples are identified, and genes with high expression levels in the tumor tissue samples are selected. Afterwards, a weight of each human tissue’s contribution to plasma exosomes is calculated using tissue-specific genes and group-enriched genes. Next, expression levels of plasma exosome genes of healthy people and cancer patients are compared by an overlapping index, and circulating biomarkers and combinations thereof suitable for detection and evaluation of plasma exosomes are selected.