摘要:
Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8 and R9, W, X and Y are as defined in the specifications. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
摘要:
Disclosed are methods of treating hyperproliferative disorders, method of treating inflammatory disorders, and methods of inhibiting MEK activity in a mammal, comprising administering an effective amount of one or more compounds of the Formula V or pharmaceutically acceptable salts thereof, wherein R1, R2, R7, R8, R9 and W are as defined in the specification.
摘要:
Compounds of Formula I are useful for inhibiting AKT protein kinases. Methods using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed. Formula (I).
摘要:
Compounds of Formula I are useful for inhibiting AKT protein kinases. Methods using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed. Formula (I).
摘要:
Systems and methods according to these exemplary embodiments provide for methods and systems related to optical current and voltage sensors and, more particularly, to filters for use in such sensors.
摘要:
Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R8, R9 and R10, W, X, and Z are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
摘要:
Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8, R9, and W are as defined in the specification. Such compounds are MEK inhibitors and are useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, and inflammatory conditions in mammals. Also disclosed are methods of using such compounds in the treatment of hyperproliferative and inflammatory diseases in mammals and pharmaceutical compositions containing such compounds.
摘要:
A sensor provides an analog sensor output signal that is first converted by a A/D converter, followed by a digital signal processor having a digital signal output that is converted to an analog signal by way of a D/A converter so as to provide an analog information output signal indicative of a parameter quantity intended to be sensed. An analog dither signal and/or a digital dither signal is provided for modulating the A/D converter input signal and/or D/A converter input signal, respectively, separately, or in combination, to enhance dynamic range accuracy of the resultant analog information output signal representative of the quantity of the parameter intended to be sensed.
摘要:
A system and method for achieving, while using a laser and optical fibers, high signal-to-noise ratio. In particular, the system splits an incoming main light signal into two orthogonal polarization states, which then propagate through an optical circuit before recombining. The use of appropriate path differences ensures that the system is immune from the conversion of mode partition noise to intensity noise arising from the interference between parasitic light waves which traveled through the system in undesired polarization states.