公开(公告)号：US11241437B2

公开(公告)日：2022-02-08

申请号：US17172984

申请日：2021-02-10

Applicant: InventisBio Co., Ltd.

Inventor： Xing Dai ,  Yueheng Jiang ,  Yanqin Liu

IPC: C07D487/04 ,  A61K31/505 ,  A61P35/00 ,  A61K31/519 ,  A61K45/06 ,  C07D471/04

Abstract: Provided herein are compounds, crystalline forms, and pharmaceutical compositions of Compound 1 and/or Compound 2. Also provided are methods of treating a disease or disorder such as a cancer or infectious disease that comprises administering to a subject in need thereof one or more of the compounds or compositions of the present disclosure.

公开(公告)号：US11091481B2

公开(公告)日：2021-08-17

申请号：US17172988

申请日：2021-02-10

Applicant: InventisBio Co., Ltd.

Inventor： Xing Dai

IPC: C07D471/04 ,  C07D519/00 ,  A61P35/00 ,  A61K31/519 ,  A61K33/243 ,  A61K31/438 ,  A61K31/282

Abstract: Provided herein are novel compounds, for example, compounds having a Formula (I) or Formula (II), or a pharmaceutically acceptable salt thereof. Also provided herein are methods of preparing the compounds and methods of using the compounds, for example, in inhibiting KRAS G12C in a cell, and/or in treating various cancer such as pancreatic cancer, endometrial cancer, colorectal cancer, or lung cancer (e.g., non-small cell lung cancer).