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公开(公告)号:US4990529A
公开(公告)日:1991-02-05
申请号:US334249
申请日:1989-04-06
申请人: Hiroyuki Yamashita , Makoto Odate , Hajime Iizuka , Hiroshi Kawazura , Yoshio Shiga , Hiroshi Namekawa
发明人: Hiroyuki Yamashita , Makoto Odate , Hajime Iizuka , Hiroshi Kawazura , Yoshio Shiga , Hiroshi Namekawa
IPC分类号: A61K31/415 , C07D231/06 , C07D401/04 , C07D401/06 , C07D403/06 , C07D405/06 , C07D405/14 , C07D409/06
CPC分类号: C07D231/06 , C07D401/04 , C07D401/06 , C07D403/06 , C07D405/06 , C07D405/14 , C07D409/06
摘要: 2-Pyrazoline derivatives of the formula (A): ##STR1## where R.sup.1 is a pyridyl, a pyrazyl or an alkoxyl group; and R.sup.2 is a hydrogen atom, an alkyl, a pyridyl, a furyl, phenyl or a substituted phenyl group, and to a process for producing the same. Therapeutic agents for treating cerebrovascular diseases containing, as the active ingredient, a 2-pyrazoline derivative represented by the formula (G): ##STR2## where R.sup.3 is a hydrogen atom, an alkyl, acetyl, an alkoxycarbonyl, an amino, benzoyl, a substituted benzoyl, a pyridylcarbonyl, a furylcabonyl, a thienylcarbonyl, a pyrazylocarbonyl, an N-substituted carbamoyl, an N-substituted thiocarbamoyl, or carboxyl group; and R.sup.4 is a hydrogen atom, an alkyl, a pyridyl, a thienyl, a furyl, cyclohexyl, phenyl or a substituted phenyl group or a pharmaceutically acceptable salt thereof. These therapeutic agents cope with cerebral edemas in the acute stage of cerebral apoplexy and regulates the whole-body and intracranial body circulation, thereby protecting ischemic lesions and minimizing the spread to affected parts.
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公开(公告)号:US4205056A
公开(公告)日:1980-05-27
申请号:US28990
申请日:1979-04-11
CPC分类号: C01B3/0089
摘要: A process for ortho-para-hydrogen conversion characterized by the use as a catalyst of a sulphur-containing semiconductive polymer produced by the dehalogenation of a poly(tetrahalophenylene sulphide) in the presence or absence of an organic solvent at 150.degree.-500.degree. C.
摘要翻译: 用于邻 - 对 - 氢转化的方法,其特征在于在有机溶剂存在或不存在下,在150-500℃下,通过使聚(四卤代苯硫醚)脱卤制得的含硫半导体聚合物的催化剂 。
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公开(公告)号:US4839376A
公开(公告)日:1989-06-13
申请号:US206812
申请日:1988-06-15
申请人: Hiroyuki Yamashita , Makoto Odate , Hajime Iizuka , Hiroshi Kawazura , Yoshio Shiga , Hiroshi Namekawa
发明人: Hiroyuki Yamashita , Makoto Odate , Hajime Iizuka , Hiroshi Kawazura , Yoshio Shiga , Hiroshi Namekawa
IPC分类号: A61K31/415 , C07D231/06 , C07D401/04 , C07D401/06 , C07D403/06 , C07D405/06 , C07D405/14 , C07D409/06
CPC分类号: C07D231/06 , C07D401/04 , C07D401/06 , C07D403/06 , C07D405/06 , C07D405/14 , C07D409/06
摘要: 2-Pyrazoline derivatives of the formula (A): ##STR1## where R.sup.1 is a pyridyl, a pyrazyl or an alkoxy group; and R.sup.2 is a hydrogen atom, an alkyl, a pyridyl, a furyl, phenyl or a substituted phenyl group, and to a process for producing the same. Therapeutic agents for treating cerebrovascular diseases containing, as the active ingredient, a 2-pyrazoline derivative represented by the formula (G): ##STR2## where R.sup.3 is a hydrogen atom, an alkyl, acetyl, an alkoxycarbonyl, an amino, benzoyl, a substituted benzoyl, a pyridylcarbonyl, a furylcarbonyl, a thienylcarbonyl, a pyrazylcarbonyl, an N-substituted carbamoyl, an N-substituted thiocarbamoyl, or carboxy group; and R.sup.4 is a hydrogen atom, an alkyl, a pyridyl, a thienyl, a furyl, cyclohexyl, phenyl or a substituted phenyl group or a pharmaceutically acceptable salt thereof. These therapeutic agents cope with cerebral edemas in the acute stage of cerebral apoplexy and regulates the whole-body and intracranial body circulation, thereby protecting ischemic lesions and minimizing the spread to affected parts.
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