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11.发明授权公开(公告)号：US06962970B2
公开(公告)日：2005-11-08
申请号：US10092088
申请日：2002-03-06
申请人： J. Kevin Judice , Paul Ross Fatheree , Bernice M. T. Lam , Michael R. Leadbetter , Martin S. Linsell , YongQi Mu , Sean Gary Trapp , Guang Yang , Yan Zhu
发明人： J. Kevin Judice , Paul Ross Fatheree , Bernice M. T. Lam , Michael R. Leadbetter , Martin S. Linsell , YongQi Mu , Sean Gary Trapp , Guang Yang , Yan Zhu
IPC分类号： A61K38/00 , A61K20060101 , A61K38/14 , A61P31/04 , C07K20060101 , C07K7/06 , C07K9/00 , C07K7/50
摘要： Disclosed are derivatives of glycopeptide compounds having at least one substituent of the formula: —Ra—Y—Rb—(Z)x where Ra, Rb, Y, Z and x are as defined, and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
摘要翻译： 公开了具有至少一个下式的取代基的糖肽化合物的衍生物：<？in-line-formula description =“In-line Formulas”end =“lead”？> - R < （Z） <？in-line-formula description =“In-line Formulas”end =“tail”？>其中R a
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公开(公告)号：US06455669B1
公开(公告)日：2002-09-24
申请号：US09674456
申请日：2000-11-01
申请人： J. Kevin Judice , Paul Ross Fatheree , Bernice M. T. Lam , Michael Leadbetter , Martin Sheringham linsell , YongQi Mu , Sean Gary Trapp , Guang Yang , Yan Zhu
发明人： J. Kevin Judice , Paul Ross Fatheree , Bernice M. T. Lam , Michael Leadbetter , Martin Sheringham linsell , YongQi Mu , Sean Gary Trapp , Guang Yang , Yan Zhu
IPC分类号： C07K750
摘要： Disclosed are derivatives of glycopeptide compounds having at least one substituent of the formula: —Ra—Y—Rb—(Z)x where Ra, Rb, Y, Z and x are as defined, and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
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13.发明授权公开(公告)号：US06444786B1
公开(公告)日：2002-09-03
申请号：US09656473
申请日：2000-09-06
申请人： J. Kevin Judice , Paul Ross Fatheree , Bernice M. T. Lam , Michael R. Leadbetter , Martin S. Linsell , YongQi Mu , Sean Gary Trapp , Guang Yang , Yan Zhu
发明人： J. Kevin Judice , Paul Ross Fatheree , Bernice M. T. Lam , Michael R. Leadbetter , Martin S. Linsell , YongQi Mu , Sean Gary Trapp , Guang Yang , Yan Zhu
IPC分类号： C07K750
摘要： Disclosed are derivatives of glycopeptide compounds having at least one substituent of the formula: —Ra—Y—Rb—(Z)x where Ra, Rb, Y, Z and x are as defined, and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
摘要翻译： 公开了具有至少一个下式的取代基的糖肽化合物的衍生物：其中Ra，Rb，Y，Z和x如所定义，以及含有这些糖肽衍生物的药物组合物。 所公开的糖肽衍生物可用作抗菌剂。
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公开(公告)号：US06518242B1
公开(公告)日：2003-02-11
申请号：US09253670
申请日：1999-02-19
申请人： Qi-Qi Chen , John H. Griffin , Thomas E. Jenkins , J. Kevin Judice , Martin S. Linsell , Michael R. Leadbetter
发明人： Qi-Qi Chen , John H. Griffin , Thomas E. Jenkins , J. Kevin Judice , Martin S. Linsell , Michael R. Leadbetter
IPC分类号： A61K3812
摘要： Novel antibacterial agents that act as multibinding agents are disclosed. The compounds of the invention comprise from 2-10 ligands covalently connected, each of said ligands being capable of binding to a transglycosylase enzyme substrate thereby modulating the biological processes/functions thereof.
摘要翻译： 公开了作为多结合剂的新型抗菌剂。 本发明的化合物包含共价连接的2-10个配体，每个所述配体能够结合转糖基酶底物，从而调节其生物学过程/功能。
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公开(公告)号：US06495681B1
公开(公告)日：2002-12-17
申请号：US09690019
申请日：2000-10-17
申请人： Sabine M. Axt , Timothy J. Church , Witold Hruzewicz , John R. Jacobsen , Thomas E. Jenkins , Yu-Hua Ji , J. Kevin Judice
发明人： Sabine M. Axt , Timothy J. Church , Witold Hruzewicz , John R. Jacobsen , Thomas E. Jenkins , Yu-Hua Ji , J. Kevin Judice
IPC分类号： C07D27308
CPC分类号： C07C237/34 , C07C237/04 , C07D211/60 , C07D273/00
摘要： Novel compounds, pharmaceutical compositions and methods are disclosed for producing local anesthesia of long-duration. The compounds of this invention are multibinding compounds that comprise from 2 to 10 ligands covalently attached to a linker or linkers, each ligand being capable of binding to a ligand binding site in a voltage-gated Na+ channel to modulate the biological processes/functions thereof.
摘要翻译： 公开了新的化合物，药物组合物和方法用于产生长时间的局部麻醉。 本发明的化合物是包含共价连接到连接体或连接体的2至10个配体的多结合化合物，每个配体能够结合电压门控Na +通道中的配体结合位点以调节其生物学过程/功能。
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公开(公告)号：US06462034B1
公开(公告)日：2002-10-08
申请号：US09411331
申请日：1999-10-01
申请人： Sabine M. Axt , Timothy J. Church , John R. Jacobsen , Thomas E. Jenkins , Yu-Hua Ji , J. Kevin Judice , Huiwei Wu , Witold Hruzewicz
发明人： Sabine M. Axt , Timothy J. Church , John R. Jacobsen , Thomas E. Jenkins , Yu-Hua Ji , J. Kevin Judice , Huiwei Wu , Witold Hruzewicz
IPC分类号： A61K4372
CPC分类号： C07C237/04 , C07C237/34 , C07D211/60 , C07D273/00
摘要： Novel compounds, pharmaceutical compositions and methods are disclosed for producing local anesthesia of long-duration. The compounds of this invention are multibinding compounds that comprise from 2 to 10 ligands covalently attached to a linker or linkers, each ligand being capable of binding to a ligand binding site in a voltage-gated Na+ channel to modulate the biological processes/functions thereof.
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公开(公告)号：US07157554B2
公开(公告)日：2007-01-02
申请号：US11080130
申请日：2005-03-15
IPC分类号： C07K9/00
CPC分类号： B82Y5/00 , A61K9/0014 , A61K9/0019 , A61K38/00 , A61K47/40 , A61K47/6951 , C07K9/008
摘要： Disclosed are glycopeptide derivatives substituted at the C-terminus and/or the R-terminus with a substituent that comprises one or more saccharide groups and a carboxy group; and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
摘要翻译： 公开了在C-末端和/或R末端被包含一个或多个糖基和羧基的取代基取代的糖肽衍生物; 和含有这些糖肽衍生物的药物组合物。 所公开的糖肽衍生物可用作抗菌剂。
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公开(公告)号：US06576791B1
公开(公告)日：2003-06-10
申请号：US09647802
申请日：2000-10-03
申请人： Sabine M. Axt , Timothy J. Church , Witold N. Hruzewicz , John R. Jacobsen , Thomas E. Jenkins , Yu-Hua Ji , J. Kevin Judice
发明人： Sabine M. Axt , Timothy J. Church , Witold N. Hruzewicz , John R. Jacobsen , Thomas E. Jenkins , Yu-Hua Ji , J. Kevin Judice
IPC分类号： C07C23305
CPC分类号： C07C237/34 , C07C237/04 , C07D211/60 , C07D273/00
摘要： Novel compounds, pharmaceutical compositions and methods are disclosed for producing local anesthesia of long-duration. The compounds of this invention are multibinding compounds that comprise from 2 to 10 ligands covalently attached to a linker or linkers, each ligand being capable of binding to a ligand binding site in a voltage-gated Na+ channel to modulate the biological processes/functions thereof.
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公开(公告)号：US06380356B1
公开(公告)日：2002-04-30
申请号：US09455660
申请日：1999-12-07
申请人： John H. Griffin , J. Kevin Judice
发明人： John H. Griffin , J. Kevin Judice
IPC分类号： A61K3812
CPC分类号： C07K7/62 , A61K38/00 , Y02A50/475 , Y02A50/481
摘要： Disclosed are multibinding compounds which are antibiotics effective against bacterial infections, in particular, Gram-negative bacterial infections. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is a polymyxin, circulin or octapeptin antibiotic or other suitable compound which binds to the LPS present in bacteria, in particular, Gram-negative bacteria. The multibinding compounds of this invention are useful for the prophylaxis and treatment of various bacterial infections caused by bacteria.
摘要翻译： 公开的是多结合化合物，其是抗细菌感染的抗生素，特别是革兰氏阴性细菌感染。 含有2-10个配体的本发明的多相结合化合物共价连接到一个或多个接头上。 每种配体是多粘菌素，环状蛋白或八肽素抗生素或其它适合的化合物，其结合存在于细菌中的LPS，特别是革兰氏阴性菌。 本发明的多结合化合物可用于预防和治疗由细菌引起的各种细菌感染。
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公开(公告)号：US07265086B2
公开(公告)日：2007-09-04
申请号：US11589614
申请日：2006-10-30
CPC分类号： B82Y5/00 , A61K9/0014 , A61K9/0019 , A61K38/00 , A61K47/40 , A61K47/6951 , C07K9/008
摘要： Disclosed are glycopeptide derivatives substituted at the C-terminus and/or the R-terminus with a substituent that comprises one or more saccharide groups and a carboxy group; and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
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