公开(公告)号：US08529958B2

公开(公告)日：2013-09-10

申请号：US13177029

申请日：2011-07-06

申请人： Phil G. Campbell ,  James E. Burgess ,  Lee E. Weiss ,  Jason Smith

发明人： Phil G. Campbell ,  James E. Burgess ,  Lee E. Weiss ,  Jason Smith

IPC分类号： A61K35/16

CPC分类号： A61K35/16 ,  A61K38/18 ,  A61K38/19 ,  A61K38/22 ,  A61K38/37 ,  A61L27/3616 ,  A61L27/365 ,  A61L27/54

摘要： Blood-derived plastic articles prepared from compositions including blood and, in some embodiments, at least one crosslinking agent and/or at least one biological response modifier, that can be useful for biological applications such as wound repair and tissue grafts; methods of making and using the same; methods for assessing the concentration of a biological response modifier in an article; and systems for preparing blood-derived plastic articles are provided.

公开(公告)号：US20120003324A1

公开(公告)日：2012-01-05

申请号：US13177061

申请日：2011-07-06

申请人： Phil G. Campbell ,  James E. Burgess ,  Lee E. Weiss ,  Jason Smith

发明人： Phil G. Campbell ,  James E. Burgess ,  Lee E. Weiss ,  Jason Smith

IPC分类号： A61K35/16 ,  A61B17/04 ,  A61B17/064 ,  A61K9/70

CPC分类号： A61K35/16 ,  A61K38/18 ,  A61K38/19 ,  A61K38/22 ,  A61K38/37 ,  A61L27/3616 ,  A61L27/365 ,  A61L27/54

摘要： Blood-derived plastic articles prepared from compositions including blood and, in some embodiments, at least one crosslinking agent and/or at least one biological response modifier, that can be useful for biological applications such as wound repair and tissue grafts; methods of making and using the same; methods for assessing the concentration of a biological response modifier in an article; and systems for preparing blood-derived plastic articles are provided.

公开(公告)号：US20100254900A1

公开(公告)日：2010-10-07

申请号：US11495115

申请日：2006-07-28

申请人： Phil G. Campbell ,  Lee E. Weiss ,  Jason Smith

发明人： Phil G. Campbell ,  Lee E. Weiss ,  Jason Smith

IPC分类号： A61K51/00 ,  A61K38/20 ,  A61K38/21 ,  A61K49/06 ,  A61K49/04 ,  A61K49/00 ,  A61K38/36 ,  A61K38/38 ,  A61K38/39 ,  A61K9/00 ,  A61K39/395 ,  A61K38/18 ,  A61K38/19 ,  A61P31/12 ,  A61P29/00 ,  A61P31/00

CPC分类号： C12N5/0068 ,  A61L27/18 ,  A61L27/502 ,  A61L27/54 ,  A61L2300/252 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/414 ,  C12N2533/56 ,  C12N2533/90 ,  C12N2535/10 ,  C08L89/00

摘要： Compositions and methods for manufacturing polymers are disclosed. Compositions include novel plastics, including films and shaped forms comprising polymer matrices that are biologically compatible and biodegradable. Such plastics may comprise polymers derived from natural sources. Further, such plastics are useful in biological systems for wound repair, implants, stents, drug encapsulation and delivery, and other applications. The disclosed methods comprise mild manufacturing processes such that various additives, such as biologically active proteins, sugars, lipids, and the like may be incorporated into the polymer matrix without subsequent loss of bioactivity during processing. Additionally, methods of manufacture for controlling mechanical properties, such as elasticity, pliancy, and the porosity of such plastics are disclosed.

摘要翻译： 公开了制备聚合物的组合物和方法。 组合物包括新型塑料，包括膜和成形形式，其包含生物相容性和可生物降解的聚合物基质。 这种塑料可以包含衍生自天然来源的聚合物。 此外，这种塑料可用于伤口修复，植入物，支架，药物包封和递送以及其它应用的生物系统中。 所公开的方法包括温和的制备方法，使得可以将各种添加剂，例如生物活性蛋白质，糖，脂质等掺入聚合物基质中，而不会在加工过程中随后丧失生物活性。 此外，公开了用于控制这种塑料的机械性能如弹性，柔软度和孔隙率的制造方法。