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公开(公告)号:US20050143352A1
公开(公告)日:2005-06-30
申请号:US10877928
申请日:2004-06-25
申请人: Mark Nelson , Kwasi Ohemeng , Paul Abato , Victor Amoo , Haregewein Assefa , Joel Berniac , Beena Bhatia , Todd Bowser , Jackson Chen , Mark Grier , Laura Honeyman , Mohamed Ismail , Oak Kim , Jude Mathews , Rachid Mechiche
发明人: Mark Nelson , Kwasi Ohemeng , Paul Abato , Victor Amoo , Haregewein Assefa , Joel Berniac , Beena Bhatia , Todd Bowser , Jackson Chen , Mark Grier , Laura Honeyman , Mohamed Ismail , Oak Kim , Jude Mathews , Rachid Mechiche
IPC分类号: C07C237/26 , C07C271/22 , C07C271/54 , C07C275/28 , C07C275/30 , A61K31/65 , C07D221/18
CPC分类号: C07C237/48 , A61K31/65 , C07C237/26 , C07C271/22 , C07C271/54 , C07C275/28 , C07C275/30 , C07C2601/02 , C07C2601/14 , C07C2601/16 , C07C2603/46 , Y02A50/411 , Y02A50/473
摘要: The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译: 本发明至少部分地涉及新的取代的四环素化合物。 这些四环素化合物可用于治疗许多四环素化合物反应状态,例如细菌感染和肿瘤,以及四环素化合物的其它已知应用,例如阻断四环素外排和调节基因表达。
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12.
公开(公告)号:US07405235B2
公开(公告)日:2008-07-29
申请号:US10700661
申请日:2003-11-03
申请人: Stuart B. Levy , Michael N. Alekshun , Brent L. Podlogar , Kwasi Ohemeng , Atul K. Verma , Tadeusz Warchol , Beena Bhatia , Todd Bowser , Mark Grier
发明人: Stuart B. Levy , Michael N. Alekshun , Brent L. Podlogar , Kwasi Ohemeng , Atul K. Verma , Tadeusz Warchol , Beena Bhatia , Todd Bowser , Mark Grier
IPC分类号: A61K31/415 , C07D235/00
CPC分类号: A61K31/40 , A61K31/407 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/44 , A61K31/47 , A61K31/4745 , A61K31/495 , A61K31/50 , A61K31/505 , A61K31/535 , A61K31/55 , A61K31/555 , Y02A50/401 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483
摘要: Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.
摘要翻译: 提供了可用作降低微生物的抗性,毒力或生长的抗感染药物的取代的苯并咪唑化合物。 制备和使用取代的苯并咪唑化合物的方法,以及其药物制剂,例如降低抗生素抗性和抑制生物膜。
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13.
公开(公告)号:US20090131401A1
公开(公告)日:2009-05-21
申请号:US12069723
申请日:2008-02-12
申请人: Stuart B. Levy , Michael N. Alekshun , Brent L. Podlogar , Kwasi Ohemeng , Atul K. Verma , Tadeusz Warchol , Beena Bhatia , Todd Bowser , Mark Grier
发明人: Stuart B. Levy , Michael N. Alekshun , Brent L. Podlogar , Kwasi Ohemeng , Atul K. Verma , Tadeusz Warchol , Beena Bhatia , Todd Bowser , Mark Grier
IPC分类号: A61K31/553 , C07D498/04 , C12N1/36 , C07D235/04 , C07D401/02 , A61K31/422 , C07D403/02 , A61K31/427 , A61K31/5377 , A61P31/04 , C07D267/02 , A61K31/496 , A61K31/55 , C07D403/04 , C07D417/02 , A61K31/4439 , A61K31/4184 , C07D413/02 , C07K1/00 , C11D3/28
CPC分类号: A61K31/40 , A61K31/407 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/44 , A61K31/47 , A61K31/4745 , A61K31/495 , A61K31/50 , A61K31/505 , A61K31/535 , A61K31/55 , A61K31/555 , Y02A50/401 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/483
摘要: Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.
摘要翻译: 提供了可用作降低微生物的抗性,毒力或生长的抗感染药物的取代的苯并咪唑化合物。 制备和使用取代的苯并咪唑化合物的方法,以及其药物制剂,例如降低抗生素抗性和抑制生物膜。
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14.
公开(公告)号:US20050124678A1
公开(公告)日:2005-06-09
申请号:US10700661
申请日:2003-11-03
申请人: Stuart Levy , Michael Alekshun , Brent Podlogar , Kwasi Ohemeng , Atul Verma , Tadeusz Warchol , Beena Bhatia , Todd Bowser , Mark Grier
发明人: Stuart Levy , Michael Alekshun , Brent Podlogar , Kwasi Ohemeng , Atul Verma , Tadeusz Warchol , Beena Bhatia , Todd Bowser , Mark Grier
IPC分类号: A61K31/40 , A61K31/407 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/44 , A61K31/47 , A61K31/4745 , A61K31/495 , A61K31/50 , A61K31/505 , A61K31/535 , A61K31/55 , A61K31/555 , A61K31/4184
CPC分类号: A61K31/40 , A61K31/407 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/44 , A61K31/47 , A61K31/4745 , A61K31/495 , A61K31/50 , A61K31/505 , A61K31/535 , A61K31/55 , A61K31/555 , Y02A50/401 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483
摘要: Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.
摘要翻译: 提供了可用作降低微生物的抗性,毒力或生长的抗感染药物的取代的苯并咪唑化合物。 制备和使用取代的苯并咪唑化合物的方法,以及其药物制剂,例如降低抗生素抗性和抑制生物膜。
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公开(公告)号:US20070093455A1
公开(公告)日:2007-04-26
申请号:US11490867
申请日:2006-07-21
申请人: Paul Abato , Haregewein Assefa , Joel Berniac , Todd Bowser , Jackson Chen , Mark Grier , Laura Honeyman
发明人: Paul Abato , Haregewein Assefa , Joel Berniac , Todd Bowser , Jackson Chen , Mark Grier , Laura Honeyman
IPC分类号: A61K31/65 , C07C237/26
CPC分类号: C07D295/155 , C07C237/26 , C07C309/65 , C07D207/06 , C07D211/14 , C07D239/26 , C07D263/58 , C07D265/12 , C07D307/77 , C07D307/81
摘要: 10-Substituted tetracycline compounds are described.
摘要翻译: 描述了10-取代的四环素化合物。
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公开(公告)号:US20090170812A1
公开(公告)日:2009-07-02
申请号:US11823103
申请日:2007-06-25
申请人: Michael N. Alekshun , Victoria Bartlett , Lynne Garrity-Ryan , Mark Grier , Oak K. Kim , Atul K. Verma
发明人: Michael N. Alekshun , Victoria Bartlett , Lynne Garrity-Ryan , Mark Grier , Oak K. Kim , Atul K. Verma
IPC分类号: A61K31/675 , C12N1/00 , C07K14/00 , A61K31/4184 , A61K31/437 , A61K31/4196 , A61K31/421 , A61K31/5377 , A61K31/496 , A61K31/4439 , C07D235/04 , C07D471/02 , C07D249/08 , C07D263/30 , C07D413/02 , C07D403/02 , C07D401/02 , C07F9/06 , A01N43/52 , A01N43/40 , A01N43/653 , A01N43/76 , A01N43/84 , A01N43/60 , A01P1/00 , A61P31/00 , A61P13/02
CPC分类号: C07D235/22 , A61K31/4184 , A61K31/4196 , A61K31/422 , A61K31/675 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D413/12 , C07D471/04 , Y02A50/401 , Y02A50/411 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/483
摘要: Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.
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公开(公告)号:US09522872B2
公开(公告)日:2016-12-20
申请号:US12217709
申请日:2008-07-07
申请人: Farzaneh Seyedi , Tadeusz Warchol , Mark Grier
发明人: Farzaneh Seyedi , Tadeusz Warchol , Mark Grier
IPC分类号: C07C237/12 , C07C231/12
CPC分类号: C07C231/12 , C07C2603/44 , C07C237/26
摘要: Methods of synthesizing substituted tetracycline compounds are provided.
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18.
公开(公告)号:US20090131481A1
公开(公告)日:2009-05-21
申请号:US12057357
申请日:2008-03-27
申请人: Michael N. Alekshun , Victoria Bartlett , Michael Draper , Lynne Garrity-Ryan , Raina Gay , Mark Grier , Oak K. Kim , Stuart B. Levy
发明人: Michael N. Alekshun , Victoria Bartlett , Michael Draper , Lynne Garrity-Ryan , Raina Gay , Mark Grier , Oak K. Kim , Stuart B. Levy
IPC分类号: A61K31/4439 , C12N1/36 , C07H21/04 , A61K31/4184 , A01N43/52 , A01P1/00 , A61P31/04 , A01N43/40 , C07D401/02 , C07D235/22 , C07D401/14
CPC分类号: A61K31/4184 , A61K31/437 , A61K31/52
摘要: Substituted benzimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of using substituted benzimidazole compounds, in, e.g., reducing virulence and infectivity, inhibiting biofilms and treating bacterial infections are also provided.
摘要翻译: 提供了可用作降低微生物的抗性,毒力或生长的抗感染剂的取代的苯并咪唑化合物。 还提供了使用取代的苯并咪唑化合物的方法,例如降低毒力和感染性,抑制生物膜和治疗细菌感染。
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公开(公告)号:US20090156842A1
公开(公告)日:2009-06-18
申请号:US12217709
申请日:2008-07-07
申请人: Farzaneh Seyedi , Tadeusz Warchol , Mark Grier
发明人: Farzaneh Seyedi , Tadeusz Warchol , Mark Grier
IPC分类号: C07C237/26
CPC分类号: C07C231/12 , C07C2603/44 , C07C237/26
摘要: Methods of synthesizing substituted tetracycline compounds are provided.
摘要翻译: 提供了合成取代四环素化合物的方法。
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