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    Pharmaceutical compositions and methods using natriuretic peptides
    15.
    发明授权
    Pharmaceutical compositions and methods using natriuretic peptides 失效

    公开(公告)号：US06974861B2

    公开(公告)日：2005-12-13

    申请号：US10402021

    申请日：2003-03-27

    申请人： J. Jeffrey Seilhamer ,  John Lewicki ,  Robert M. Scarborough ,  J. Gordon Porter

    发明人： J. Jeffrey Seilhamer ,  John Lewicki ,  Robert M. Scarborough ,  J. Gordon Porter

    IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K38/22 ,  A61P9/08 ,  A61P9/12 ,  C07K7/08 ,  C07K14/00 ,  C07K14/575 ,  C07K14/58 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/12 ,  C12N15/16 ,  C12P21/02 ,  C12R1/19 ,  C07K17/00

    CPC分类号： C12P21/02 ,  A61K38/00 ,  C07K14/58 ,  C07K14/582 ,  C07K16/241 ,  C07K16/2803 ,  C07K2317/622 ,  G01N33/74

    摘要： The cDNA sequence encoding porcine brain natriuretic peptide and related genes encoding canine and human peptides with natriuretic activity are disclosed. The gene is shown to make accessible the DNAs encoding analogous natriuretic peptides in other vertebrate species. The genes encoding these NPs can be used to effect modifications of the sequence to produce alternate forms of the NPs and to provide practical amounts of these proteins. The NPs of the invention can also be synthesized chemically. The invention peptides have the formula: R1-Cys-Phe-Gly-Arg- Arg/ - Leu/ -Asp-Arg-                     Lys    Met                                                (1)    Ile- Gly/ -Ser- Leu/ -Ser-Gly-Leu-Gly-Cys-R-2         Ser        Ser wherein R1 is selected from the group consisting of:                                              (H);                                             Gly-;                                         Ser-Gly-;                                   Asp/                                   Lys/ -Ser-Gly-;                                   Gly                            Arg/   Asp/                            His/ - Lys/ -Ser-Gly-;                            Gln    Gly                            Arg/   Asp/                     Met/ - His/ - Lys/ -Ser-Gly-;                     Val    Gln    Gly                            Arg/   Asp/              Thr/ - Met/ - His/ - Lys/ -Ser-Gly-;              Met    Val    Gln    Gly                            Arg/   Asp/         Lys- Thr/ - Met/ - His/ - Lys/ -Ser-Gly-;              Met    Val    Gln    Gly                            Arg/   Asp/     Pro-Lys- Thr/ - Met/ - His/ - Lys/ -Ser-Gly-;              Met    Val    Gln    Gly                            Arg/   Asp/ Ser-Pro-Lys- Thr/ - Met/ - His/ - Lys/ -Ser-Gly-;              Met    Val    Gln    Gly or a 10- to 109-amino acid sequence shown as the native upstream sequence for porcine, canine or human BNP in FIG. 8, or a composite thereof; R2 is (OH), NH2, or NR′R″ wherein R′ and R″ are independently lower alkyl (1-4C) or is Asn/ Lys Asn/ -Val Lys Asn/ -Val-Leu Lys Asn/ -Val-Leu-Arg Lys Asn/ -Val-Leu-Arg- Arg/ Lys                Lys Asn/ -Val-Leu-Arg- Arg/ - Tyr/ Lys                Lys    His or the amides (NH2 or NR′R″) thereof, with the proviso that if formula (1) is R1-Cys-Phe-Gly-Arg-Arg-Leu-Asp-Arg-    Ile-Gly-Ser-Leu-Ser-Gly-Leu-Gly-Cys-R2 and R1 is Asp-Ser-Gly-, R2 cannot be Asn-Val-Leu-Arg-Arg-Tyr. The peptides of the invention can be formulated into pharmaceutical compositions and used to treat conditions associated with high extracellular fluid levels, especially congestive heart failure.

    Nucleic acid molecules encoding soluble frizzled (FZD) receptors
    19.
    发明授权
    Nucleic acid molecules encoding soluble frizzled (FZD) receptors 有权
    编码可溶性卷曲（FZD）受体的核酸分子

    公开(公告)号：US08324361B2

    公开(公告)日：2012-12-04

    申请号：US12724169

    申请日：2010-03-15

    申请人： Austin Gurney ,  John Lewicki ,  Sanjeev Satyal ,  Timothy Hoey

    发明人： Austin Gurney ,  John Lewicki ,  Sanjeev Satyal ,  Timothy Hoey

    IPC分类号： C07H21/04 ,  C12P21/06 ,  C12N1/20 ,  C12N15/00 ,  C12N5/00 ,  C12N5/02 ,  C12N15/74

    CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K45/06 ,  A61K2039/505 ,  C07K14/723 ,  C07K16/00 ,  C07K16/18 ,  C07K16/28 ,  C07K2319/30 ,  C07K2319/33 ,  G01N33/57423 ,  G01N33/57492

    摘要： The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis, characterization, prognosis and treatment of cancer and specifically targeting cancer stem cells. The present invention provides a soluble FZD receptor comprising an extracellular domain of a human FZD receptor that inhibits growth of tumor cells. The present invention still further provides a soluble receptor comprising a Fri domain of a human FZD receptor that binds a ligand of a human FZD receptor and said soluble receptor is capable of inhibiting tumor growth. The present invention still further provides a method of treating cancer comprising administering a soluble FZD receptor comprising for example, either an extracellular domain of a human FZD receptor or a Fri domain of a human FZD receptor, in an amount effective to inhibit tumor growth.

    摘要翻译： 本发明涉及用于表征，诊断和治疗癌症的组合物和方法。 特别地，本发明提供了用于癌症的诊断，表征，预后和治疗以及特异性靶向癌症干细胞的方法和方法。 本发明提供了包含抑制肿瘤细胞生长的人FZD受体的细胞外结构域的可溶性FZD受体。 本发明还提供一种可溶性受体，其包含结合人FZD受体的配体的人FZD受体的Fri结构域，并且所述可溶性受体能够抑制肿瘤生长。 本发明还提供一种治疗癌症的方法，其包括以有效抑制肿瘤生长的量施用包含例如人FZD受体的细胞外结构域或人FZD受体的Fri结构域的可溶性FZD受体。

    Compositions and Methods for Diagnosing and Treating Cancer
    20.
    发明申请
    Compositions and Methods for Diagnosing and Treating Cancer 有权
    诊断和治疗癌症的组成和方法

    公开(公告)号：US20100317098A1

    公开(公告)日：2010-12-16

    申请号：US12724169

    申请日：2010-03-15

    申请人： Austin Gurney ,  John Lewicki ,  Sanjeev Satyal ,  Timothy Hoey

    发明人： Austin Gurney ,  John Lewicki ,  Sanjeev Satyal ,  Timothy Hoey

    IPC分类号： C12N5/10 ,  C07H21/04 ,  C12N15/63

    CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K45/06 ,  A61K2039/505 ,  C07K14/723 ,  C07K16/00 ,  C07K16/18 ,  C07K16/28 ,  C07K2319/30 ,  C07K2319/33 ,  G01N33/57423 ,  G01N33/57492

    摘要： The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis, characterization, prognosis and treatment of cancer and specifically targeting cancer stem cells. The present invention provides a soluble FZD receptor comprising an extracellular domain of a human FZD receptor that inhibits growth of tumor cells. The present invention still further provides a soluble receptor comprising a Fri domain of a human FZD receptor that binds a ligand of a human FZD receptor and said soluble receptor is capable of inhibiting tumor growth. The present invention still further provides a method of treating cancer comprising administering a soluble FZD receptor comprising for example, either an extracellular domain of a human FZD receptor or a Fri domain of a human FZD receptor, in an amount effective to inhibit tumor growth.

    摘要翻译： 本发明涉及用于表征，诊断和治疗癌症的组合物和方法。 特别地，本发明提供了用于癌症的诊断，表征，预后和治疗以及特异性靶向癌症干细胞的方法和方法。 本发明提供了包含抑制肿瘤细胞生长的人FZD受体的细胞外结构域的可溶性FZD受体。 本发明还提供一种可溶性受体，其包含结合人FZD受体的配体的人FZD受体的Fri结构域，并且所述可溶性受体能够抑制肿瘤生长。 本发明还提供一种治疗癌症的方法，其包括以有效抑制肿瘤生长的量施用包含例如人FZD受体的细胞外结构域或人FZD受体的Fri结构域的可溶性FZD受体。