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公开(公告)号：US07582751B2
公开(公告)日：2009-09-01
申请号：US11193562
申请日：2005-07-29
IPC分类号： C07B47/00
CPC分类号： C07D487/22 , C07D403/04
摘要： A method of making a porphyrin (I) is carried out by condensing (i) a bis(imino)dipyrromethane of Formula II: with (ii) a dipyrromethane to produce a reaction product; then (b) optionally oxidizing said reaction product with an oxidizing agent; and then (c) optionally demetallating said reaction product to produce the porphyrin. Methods of making compounds of Formula II are also described.
摘要翻译： 制备卟啉（I）的方法是通过将（ⅰ）式Ⅱ的双（亚氨基）二吡咯烷与（ⅱ）二吡咯甲烷缩合制备反应产物来进行的; 然后（b）任选地用氧化剂氧化所述反应产物; 然后（c）任选地使所述反应产物脱金属以产生卟啉。 还描述了制备式II化合物的方法。
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公开(公告)号：US20090198049A1
公开(公告)日：2009-08-06
申请号：US12361715
申请日：2009-01-29
IPC分类号： C07D471/22 , C07D403/06
CPC分类号： C07D403/04 , C07D487/22
摘要： A method of making a porphyrin is carried out by: (a) condensing (i) a 1,9-bis(N,N-)dialkylaminomethyl)dipyrromethane of Formula II: with (ii) a dipyrromethane to produce a reaction product; then (b) oxidizing the reaction product; and then (c) optionally demetallating said reaction product to produce the porphyrin. The reaction is particularly useful for making substituted porphyrins with a wide range of substituents at the A and/or B (the 5 and/or 15) positions.
摘要翻译： 通过以下方法进行卟啉的制备方法：（a）将（ⅰ）式Ⅱ的1,9-双（N，N-）二烷基氨基甲基）二吡咯烷与（ⅱ）二吡咯甲烷缩合生成反应产物; 然后（b）氧化反应产物; 然后（c）任选地使所述反应产物脱金属以产生卟啉。 该反应对于在A和/或B（5和/或15）位置制备具有宽范围取代基的取代卟啉是特别有用的。
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13.发明申请公开(公告)号：US20220288047A1
公开(公告)日：2022-09-15
申请号：US17684579
申请日：2022-03-02
申请人： Lu Chou , Matt Duan , Ihab Darwish , Simon Shaw , Somasekhar Bhamidipati , Vanessa Taylor , Yan Chen , Dazhong Fan , Zhushou Luo
发明人： Lu Chou , Matt Duan , Ihab Darwish , Simon Shaw , Somasekhar Bhamidipati , Vanessa Taylor , Yan Chen , Dazhong Fan , Zhushou Luo
IPC分类号： A61K31/4439 , A61K45/06 , A61K31/675 , A61K31/5377 , A61P17/00
摘要： Disclosed herein are embodiments of a method for treating a disease or condition in a subject, comprising administering to the subject, a pyrazole compound according to formula I. The compound may be administered as a composition, such as a spray-dried formulation. The disease or condition may be hidradenitis suppurativa, or a lymphoid neoplasm, and may be chronic myeloid leukemia or chronic myelomonocytic leukemia.
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公开(公告)号：US20070027311A1
公开(公告)日：2007-02-01
申请号：US11192934
申请日：2005-07-29
IPC分类号： C07D487/22 , C07D403/02
CPC分类号： C07D403/04 , C07D487/22
摘要： A method of making a porphyrin is carried out by: (a) condensing (i) a 1,9-bis(N,N-)dialkylaminomethyl)dipyrromethane of Formula II: with (ii) a dipyrromethane to produce a reaction product; then (b) oxidizing the reaction product; and then (c) optionally demetallating said reaction product to produce the porphyrin. The reaction is particularly useful for making substituted porphyrins with a wide range of substituents at the A and/or B (the 5 and/or 15) positions.
摘要翻译： 通过以下方法进行卟啉的制备方法：（a）将（ⅰ）式Ⅱ的1,9-双（N，N-）二烷基氨基甲基）二吡咯烷与（ⅱ）二吡咯甲烷缩合生成反应产物; 然后（b）氧化反应产物; 然后（c）任选地使所述反应产物脱金属以产生卟啉。 该反应对于在A和/或B（5和/或15）位置制备具有宽范围取代基的取代卟啉是特别有用的。
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公开(公告)号：US20070027312A1
公开(公告)日：2007-02-01
申请号：US11193562
申请日：2005-07-29
IPC分类号： C07D487/22 , C07D403/02
CPC分类号： C07D487/22 , C07D403/04
摘要： A method of making a porphyrin (I) is carried out by condensing (i) a bis(imino)dipyrromethane of Formula II: with (ii) a dipyrromethaneto produce a reaction product; then (b) optionally oxidizing said reaction product with an oxidizing agent; and then (c) optionally demetallating said reaction product to produce the porphyrin. Methods of making compounds of Formula II are also described.
摘要翻译： 制备卟啉（I）的方法是通过将（ⅰ）式Ⅱ的双（亚氨基）二吡咯烷与（ⅱ）二吡咯甲烷缩合制备反应产物而进行的; 然后（b）任选地用氧化剂氧化所述反应产物; 然后（c）任选地使所述反应产物脱金属以产生卟啉。 还描述了制备式II化合物的方法。
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