公开(公告)号：US20090227900A1

公开(公告)日：2009-09-10

申请号：US12045308

申请日：2008-03-10

申请人： Isaac Kim ,  Ketan Muni

发明人： Isaac Kim ,  Ketan Muni

IPC分类号： A61M25/01 ,  B23P11/00

CPC分类号： A61M25/09 ,  A61B17/24 ,  A61M29/02 ,  A61M2025/09083 ,  A61M2029/025 ,  Y10T29/49908

摘要： A guidewire for use in ear, nose and throat procedures may include an elongate core wire having a proximal region and a distal region. The distal region of the core wire may include a flattened portion adapted to provide preferential flexure along at least one axis of the wire. The distal region of the core wire may include a tip portion distal of the flattened portion, where at least one cross-sectional dimension of the tip portion is greater than at least one cross-sectional dimension of the flattened portion. The guidewire may include an outer coil disposed around at least a portion of the elongate core wire. The guidewire may also include an atraumatic tip coupled to the core wire or the outer coil.

摘要翻译： 用于耳，鼻和咽喉手术的导丝可以包括具有近端区域和远侧区域的细长芯线。 芯线的远侧区域可以包括适于沿着线的至少一个轴线提供优先挠曲的平坦部分。 芯线的远侧区域可以包括在平坦部分的远侧的尖端部分，其中尖端部分的至少一个横截面尺寸大于平坦部分的至少一个横截面尺寸。 导丝可以包括围绕细长芯线的至少一部分设置的外部线圈。 导丝还可以包括连接到芯线或外线圈的无创尖端。

公开(公告)号：US08182432B2

公开(公告)日：2012-05-22

申请号：US12045308

申请日：2008-03-10

申请人： Isaac Kim ,  Ketan Muni

发明人： Isaac Kim ,  Ketan Muni

IPC分类号： A61M25/00

CPC分类号： A61M25/09 ,  A61B17/24 ,  A61M29/02 ,  A61M2025/09083 ,  A61M2029/025 ,  Y10T29/49908

摘要： A guidewire for use in ear, nose and throat procedures may include an elongate core wire having a proximal region and a distal region. The distal region of the core wire may include a flattened portion adapted to provide preferential flexure along at least one axis of the wire. The distal region of the core wire may include a tip portion distal of the flattened portion, where at least one cross-sectional dimension of the tip portion is greater than at least one cross-sectional dimension of the flattened portion. The guidewire may include an outer coil disposed around at least a portion of the elongate core wire. The guidewire may also include an atraumatic tip coupled to the core wire or the outer coil.

摘要翻译： 用于耳，鼻和咽喉手术的导丝可以包括具有近端区域和远侧区域的细长芯线。 芯线的远侧区域可以包括适于沿着线的至少一个轴线提供优先挠曲的平坦部分。 芯线的远侧区域可以包括在平坦部分的远侧的尖端部分，其中尖端部分的至少一个横截面尺寸大于平坦部分的至少一个横截面尺寸。 导丝可以包括围绕细长芯线的至少一部分设置的外部线圈。 导丝还可以包括连接到芯线或外线圈的无创尖端。

公开(公告)号：US20120227457A1

公开(公告)日：2012-09-13

申请号：US13351774

申请日：2012-01-17

申请人： Isaac Kim ,  Ketan Muni

发明人： Isaac Kim ,  Ketan Muni

IPC分类号： B21D31/00 ,  B21D43/28

CPC分类号： A61M25/09 ,  A61B17/24 ,  A61M29/02 ,  A61M2025/09083 ,  A61M2029/025 ,  Y10T29/49908

摘要： A guidewire for use in ear, nose and throat procedures may include an elongate core wire having a proximal region and a distal region. The distal region of the core wire may include a flattened portion adapted to provide preferential flexure along at least one axis of the wire. The distal region of the core wire may include a tip portion distal of the flattened portion, where at least one cross-sectional dimension of the tip portion is greater than at least one cross-sectional dimension of the flattened portion. The guidewire may include an outer coil disposed around at least a portion of the elongate core wire. The guidewire may also include an atraumatic tip coupled to the core wire or the outer coil.

摘要翻译： 用于耳，鼻和咽喉手术的导丝可以包括具有近端区域和远侧区域的细长芯线。 芯线的远侧区域可以包括适于沿着线的至少一个轴线提供优先挠曲的平坦部分。 芯线的远侧区域可以包括在平坦部分的远侧的尖端部分，其中尖端部分的至少一个横截面尺寸大于平坦部分的至少一个横截面尺寸。 导丝可以包括围绕细长芯线的至少一部分设置的外部线圈。 导丝还可以包括连接到芯线或外线圈的无创尖端。

公开(公告)号：US07048712B2

公开(公告)日：2006-05-23

申请号：US10389150

申请日：2003-03-14

申请人： Ziyun Chen ,  Tai Cheng ,  Ketan Muni ,  Udayan Patel ,  Robert Saltman

发明人： Ziyun Chen ,  Tai Cheng ,  Ketan Muni ,  Udayan Patel ,  Robert Saltman

IPC分类号： A61M25/10

CPC分类号： A61M25/1029 ,  A61L29/049 ,  A61M25/0009 ,  A61M2025/1031 ,  C08L67/02 ,  C08L77/00 ,  C08L23/00

摘要： A combination of polymeric components provides desired characteristics in forming medical instruments such as catheters and balloons for dilatation catheters. For example, a balloon material is formed from a blend of polymeric components, including a first crystalline polymeric component and a second softening polymeric component. Where the first two components are generally incompatible, the balloon material can also include a third compatibilizing agent to facilitate blending the first two polymeric components together.

摘要翻译： 聚合物组分的组合在形成用于扩张导管的导管和气囊的医疗器械中提供期望的特性。 例如，气球材料由聚合物组分的共混物形成，包括第一结晶聚合物组分和第二软化聚合物组分。 在前两种组分通常不相容的情况下，球囊材料还可以包括第三相容剂以便于将前两个聚合物组分共混在一起。

公开(公告)号：US20050107865A1

公开(公告)日：2005-05-19

申请号：US10992976

申请日：2004-11-19

申请人： Anton Clifford ,  Kevin Kang ,  David Lowe ,  Jeff Pappas ,  Erik Eli ,  Howard Huang ,  Lisa Weldon ,  Ketan Muni ,  Eugene Young

发明人： Anton Clifford ,  Kevin Kang ,  David Lowe ,  Jeff Pappas ,  Erik Eli ,  Howard Huang ,  Lisa Weldon ,  Ketan Muni ,  Eugene Young

IPC分类号： A61F2/00 ,  A61F2/06 ,  A61F2/90

CPC分类号： A61F2/915 ,  A61F2/91 ,  A61F2002/91508 ,  A61F2002/91516 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/91558 ,  A61F2220/0008 ,  A61F2230/0054 ,  A61F2250/0098 ,  Y10T29/49826 ,  Y10T29/49908

摘要： Endoprosthesis, such as a stent, includes at least one annular element defined by a first set of strut members interconnected to define apices proximate opposite sides of the annular element. The annular element further includes a foot extension extending between at least one pair of circumferentially-adjacent strut members. The foot extension has first and second foot portions extending circumferentially from corresponding ends of the circumferentially-adjacent strut members, and are contoured to provide at least two areas of flexure. The first and second foot portions are joined at a toe portion of the foot extension, and define a circumferentially-directed apex between the pair of circumferentially-adjacent strut members. Preferably, at least one or more additional annular elements, each defined by interconnected strut members, are provided. The annular elements are generally expandable between a delivery configuration and a deployed configuration. The annular elements are longitudinally aligned and connected at connection locations. Preferably, each connection location includes a foot extension, such as by an overlapping pattern between the longitudinally-adjacent annular elements or by a connector extending therebetween.

摘要翻译： 内置假体，例如支架，包括至少一个环形元件，所述至少一个环形元件由第一组支柱构件限定，所述第一组撑杆构件互相连接以限定靠近所述环形元件相对侧的顶点。 环形元件还包括在至少一对周向相邻的支柱构件之间延伸的脚延伸部。 脚部延伸部具有从周向相邻的支柱构件的对应端部周向延伸的第一和第二脚部，并且具有轮廓以提供至少两个弯曲区域。 第一和第二脚部在脚延伸部的脚趾部分处连接，并且在一对周向相邻的支柱构件之间限定圆周方向的顶点。 优选地，提供至少一个或多个另外的环形元件，每个环形元件由互连的支柱构件限定。 环形元件通常在输送配置和展开配置之间可扩展。 环形元件在连接位置处纵向对齐并连接。 优选地，每个连接位置包括脚部延伸部，例如通过在纵向相邻的环形元件之间的重叠图案，或者通过在它们之间延伸的连接器。

公开(公告)号：US06796958B2

公开(公告)日：2004-09-28

申请号：US09453984

申请日：1999-12-02

申请人： Ziyun Chen ,  Tai Cheng ,  Ketan Muni ,  Udayan Patel ,  Robert Saltman

发明人： Ziyun Chen ,  Tai Cheng ,  Ketan Muni ,  Udayan Patel ,  Robert Saltman

IPC分类号： A61M2510

CPC分类号： A61M25/1029 ,  A61L29/049 ,  A61M25/0009 ,  A61M2025/1031 ,  C08L67/02 ,  C08L77/00 ,  C08L23/00

摘要： A combination of polymeric components provides desired characteristics in forming medical instruments such as catheters and balloons for dilatation catheters. For example, a balloon material is formed from a blend of polymeric components, including a first crystalline polymeric component and a second softening polymeric component. Where the first two components are generally incompatible, the balloon material can also include a third compatibilizing agent to facilitate blending the first two polymeric components together.

摘要翻译： 聚合物组分的组合在形成用于扩张导管的导管和气囊的医疗器械中提供期望的特性。 例如，气球材料由聚合物组分的共混物形成，包括第一结晶聚合物组分和第二软化聚合物组分。 在前两种组分通常不相容的情况下，球囊材料还可以包括第三相容剂以便于将前两个聚合物组分混合在一起。

公开(公告)号：US6013728A

公开(公告)日：2000-01-11

申请号：US856733

申请日：1997-05-15

申请人： Ziyun Chen ,  Tai Cheng ,  Ketan Muni ,  Udayan Patel ,  Robert Saltman

发明人： Ziyun Chen ,  Tai Cheng ,  Ketan Muni ,  Udayan Patel ,  Robert Saltman

IPC分类号： A61L29/00 ,  A61F2/958 ,  A61L29/04 ,  A61M25/00 ,  A61M25/16 ,  C08L23/02 ,  C08L67/00 ,  C08L67/02 ,  C08L77/00

CPC分类号： A61M25/1029 ,  A61L29/049 ,  C08L67/02 ,  A61M2025/1031 ,  A61M25/0009

摘要： A combination of polymeric components provides desired characteristics in forming medical instruments such as catheters and balloons for dilatation catheters. For example, a balloon material is formed from a blend of polymeric components, including a first crystalline polymeric component and a second softening polymeric component. Where the first two components are generally incompatible, the balloon material can also include a third compatibilizing agent to facilitate blending the first two polymeric components together. The first polymeric component can be a branched or straight chain polyamide having a molecular weight of at least about 5000, or a polyester prepared from aromatic dicarboxylic acids having 8 to 14 carbon atoms or aliphatic dicarboxylic acids having from 2 to 12 carbon atoms, and at least one glycol having the formula HO(CH.sub.2).sub.n OH, where n is an integer from 2 to 10, neopentyl glycol and cyclohexane dimethanol. The second polymeric component can be a polyolefin, an ethylene copolymer, a polyester block copolymer, or a polyamide block copolymer. The third polymeric component is preferably an ethylene copolymer having the formula E/X/Y where E is ethylene; X is an .alpha., .beta.-ethylenically unsaturated monomer derived from at least one of alkylacrylate, alkylmethacrylate, alkyl vinyl ether, carbon monoxide, sulfur dioxide, or mixtures thereof, where the alkyl groups contain 1-12 carbon atoms; and Y is an .alpha., .beta.-ethylenically unsaturated monomer containing a reactive group that forms a covalent bond with the first polymeric component. The polymeric blend can be irradiated to enhance the properties of the balloon material, including significantly increasing burst pressures.

摘要翻译： 聚合物组分的组合在形成用于扩张导管的导管和气囊的医疗器械中提供期望的特性。 例如，气球材料由聚合物组分的共混物形成，包括第一结晶聚合物组分和第二软化聚合物组分。 在前两种组分通常不相容的情况下，球囊材料还可以包括第三相容剂以便于将前两个聚合物组分混合在一起。 第一聚合物组分可以是分子量为至少约5000的支链或直链聚酰胺，或由具有8至14个碳原子的芳族二羧酸或具有2至12个碳原子的脂族二羧酸制备的聚酯，以及在 至少一种具有式HO（CH 2）n OH的二醇，其中n为2-10的整数，新戊二醇和环己烷二甲醇。 第二聚合物组分可以是聚烯烃，乙烯共聚物，聚酯嵌段共聚物或聚酰胺嵌段共聚物。 第三聚合物组分优选是具有式E / X / Y的乙烯共聚物，其中E是乙烯; X是衍生自丙烯酸烷基酯，甲基丙烯酸烷基酯，烷基乙烯基醚，一氧化碳，二氧化硫或其混合物中的至少一种的α，β-烯属不饱和单体，其中烷基含有1-12个碳原子; 并且Y是含有与第一聚合物组分形成共价键的反应性基团的α，β-烯属不饱和单体。 可以照射聚合物共混物以增强球囊材料的性质，包括显着增加爆破压力。

公开(公告)号：US07625398B2

公开(公告)日：2009-12-01

申请号：US10992976

申请日：2004-11-19

申请人： Anton Clifford ,  Kevin Kang ,  David Lowe ,  Jeff Pappas ,  Erik Eli ,  Howard Huang ,  Lisa Weldon ,  Ketan Muni ,  Eugene Young

发明人： Anton Clifford ,  Kevin Kang ,  David Lowe ,  Jeff Pappas ,  Erik Eli ,  Howard Huang ,  Lisa Weldon ,  Ketan Muni ,  Eugene Young

IPC分类号： A61F2/06

CPC分类号： A61F2/915 ,  A61F2/91 ,  A61F2002/91508 ,  A61F2002/91516 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/91558 ,  A61F2220/0008 ,  A61F2230/0054 ,  A61F2250/0098 ,  Y10T29/49826 ,  Y10T29/49908

摘要： Endoprosthesis, such as a stent, includes at least one annular element defined by a first set of strut members interconnected to define apices proximate opposite sides of the annular element. The annular element further includes a foot extension extending between at least one pair of circumferentially-adjacent strut members. The foot extension has first and second foot portions extending circumferentially from corresponding ends of the circumferentially-adjacent strut members, and are contoured to provide at least two areas of flexure. The first and second foot portions are joined at a toe portion of the foot extension, and define a circumferentially-directed apex between the pair of circumferentially-adjacent strut members. Preferably, at least one or more additional annular elements, each defined by interconnected strut members, are provided. The annular elements are generally expandable between a delivery configuration and a deployed configuration. The annular elements are longitudinally aligned and connected at connection locations. Preferably, each connection location includes a foot extension, such as by an overlapping pattern between the longitudinally-adjacent annular elements or by a connector extending therebetween.

公开(公告)号：US5554120A

公开(公告)日：1996-09-10

申请号：US280764

申请日：1994-07-25

申请人： Ziyun Chen ,  Tai Cheng ,  Ketan Muni ,  Udayan Patel ,  Robert Saltman

发明人： Ziyun Chen ,  Tai Cheng ,  Ketan Muni ,  Udayan Patel ,  Robert Saltman

IPC分类号： A61L29/00 ,  A61F2/958 ,  A61L29/04 ,  A61M25/00 ,  A61M25/16 ,  C08L23/02 ,  C08L67/00 ,  C08L67/02 ,  C08L77/00 ,  A61M25/10 ,  A61M29/02

CPC分类号： A61M25/1029 ,  A61L29/049 ,  C08L67/02 ,  A61M2025/1031 ,  A61M25/0009

摘要： A combination of polymeric components provides desired characteristics in forming medical instruments such as catheters and balloons for dilatation catheters. For example, a balloon material is formed from a blend of polymeric components, including a first crystalline polymeric component and a second softening polymeric component. Where the first two components are generally incompatible, the balloon material can also include a third compatibilizing agent to facilitate blending the first two polymeric components together. The first polymeric component can be a branched or straight chain polyamide having a molecular weight of at least about 5000, or a polyester prepared from aromatic dicarboxylic acids having 8 to 14 carbon atoms or aliphatic dicarboxylic acids having from 2 to 12 carbon atoms, and at least one glycol having the formula HO(CH.sub.2).sub.n OH, where n is an integer from 2 to 10, neopentyl glycol and cyclohexane dimethanol. The second polymeric component can be a polyolefin, an ethylene copolymer, a polyester block copolymer, or a polyamide block copolymer. The third polymeric component is preferably an ethylene copolymer having the formula E/X/Y where E is ethylene; X is an .alpha., .beta.-ethylenically unsaturated monomer derived from at least one of alkylacrylate, alkylmethacrylate, alkyl vinyl ether, carbon monoxide, sulfur dioxide, or mixtures thereof, where the alkyl groups contain 1-12 carbon atoms; and Y is an .alpha., .beta.-ethylenically unsaturated monomer containing a reactive group that forms a covalent bond with the first polymeric component. The polymeric blend can be irradiated to enhance the properties of the balloon material, including significantly increasing burst pressures.

公开(公告)号：US5747591A

公开(公告)日：1998-05-05

申请号：US742272

申请日：1996-10-31

申请人： Ziyun Chen ,  Tai Cheng ,  Ketan Muni ,  Udayan Patel ,  Robert Saltman

发明人： Ziyun Chen ,  Tai Cheng ,  Ketan Muni ,  Udayan Patel ,  Robert Saltman

IPC分类号： A61L29/00 ,  A61F2/958 ,  A61L29/04 ,  A61M25/00 ,  A61M25/16 ,  C08L23/02 ,  C08L67/00 ,  C08L67/02 ,  C08L77/00 ,  A61M25/10

CPC分类号： A61M25/1029 ,  A61L29/049 ,  C08L67/02 ,  A61M2025/1031 ,  A61M25/0009

摘要： A combination of polymeric components provides desired characteristics in forming medical instruments such as catheters and balloons for dilatation catheters. For example, a balloon material is formed from a blend of polymeric components, including a first crystalline polymeric component and a second softening polymeric component. Where the first two components are generally incompatible, the balloon material can also include a third compatibilizing agent to facilitate blending the first two polymeric components together. The first polymeric component can be a branched or straight chain polyamide having a molecular weight of at least about 5000, or a polyester prepared from aromatic dicarboxylic acids having 8 to 14 carbon atoms or aliphatic dicarboxylic acids having from 2 to 12 carbon atoms, and at least one glycol having the formula HO(CH.sub.2).sub.n OH, where n is an integer from 2 to 10, neopentyl glycol and cyclohexane dimethanol. The second polymeric component can be a polyolefin, an ethylene copolymer, a polyester block copolymer, or a polyamide block copolymer. The third polymeric component is preferably an ethylene copolymer having the formula E/X/Y where E is ethylene; X is an .alpha., .beta.-ethylenically unsaturated monomer derived from at least one of alkylacrylate, alkylmethacrylate, alkyl vinyl ether, carbon monoxide, sulfur dioxide, or mixtures thereof, where the alkyl groups contain 1-12 carbon atoms; and Y is an .alpha., .beta.-ethylenically unsaturated monomer containing a reactive group that forms a covalent bond with the first polymeric component. The polymeric blend can be irradiated to enhance the properties of the balloon material, including significantly increasing burst pressures.

摘要翻译： 聚合物组分的组合在形成用于扩张导管的导管和气囊的医疗器械中提供期望的特性。 例如，气球材料由聚合物组分的共混物形成，包括第一结晶聚合物组分和第二软化聚合物组分。 在前两种组分通常不相容的情况下，球囊材料还可以包括第三相容剂以便于将前两个聚合物组分混合在一起。 第一聚合物组分可以是分子量为至少约5000的支链或直链聚酰胺，或由具有8至14个碳原子的芳族二羧酸或具有2至12个碳原子的脂族二羧酸制备的聚酯，以及在 至少一种具有式HO（CH 2）n OH的二醇，其中n为2-10的整数，新戊二醇和环己烷二甲醇。 第二聚合物组分可以是聚烯烃，乙烯共聚物，聚酯嵌段共聚物或聚酰胺嵌段共聚物。 第三聚合物组分优选是具有式E / X / Y的乙烯共聚物，其中E是乙烯; X是衍生自丙烯酸烷基酯，甲基丙烯酸烷基酯，烷基乙烯基醚，一氧化碳，二氧化硫或其混合物中的至少一种的α，β-烯属不饱和单体，其中烷基含有1-12个碳原子; 并且Y是含有与第一聚合物组分形成共价键的反应性基团的α，β-烯属不饱和单体。 可以照射聚合物共混物以增强球囊材料的性质，包括显着增加爆破压力。