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22 条记录 (耗时 0.061 秒)

    Method for preparing nitrogen containing compounds
    14.
    发明授权
    Method for preparing nitrogen containing compounds 失效
    含氮化合物的制备方法

    公开(公告)号：US06803472B2

    公开(公告)日：2004-10-12

    申请号：US10296925

    申请日：2002-11-29

    申请人： Takashi Emura ,  Tsuyoshi Haneishi

    发明人： Takashi Emura ,  Tsuyoshi Haneishi

    IPC分类号： C07D20730

    CPC分类号： C07C335/32 ,  C07C231/02 ,  C07C257/14 ,  C07C257/18 ,  C07C277/02 ,  C07C233/07 ,  C07C279/18

    摘要： A synthesis method which comprises reacting NH group-containing compounds with thiocyanates, cyanamides, nitrites or esters in the presence of a silylating agent to synthesize the corresponding nitrogen-containing addition or substitution products. This method not only enables the direct and efficient synthesis of nitrogen-containing compounds including isothioureas, guanidines, amidines and amides, but it also has a wide range of applications and is suitable for large-scale synthesis.

    摘要翻译： 一种合成方法，其包括在甲硅烷基化剂存在下使含NH基的化合物与硫氰酸酯，氰胺，亚硝酸酯或酯反应以合成相应的含氮加成或取代产物。 该方法不仅可以直接有效地合成含氮化合物，包括异硫脲，胍，脒和酰胺，而且还具有广泛的应用范围，适用于大规模合成。

    Method for preparing nitrogen-containing compounds
    16.
    发明授权
    Method for preparing nitrogen-containing compounds 失效
    含氮化合物的制备方法

    公开(公告)号：US07087783B2

    公开(公告)日：2006-08-08

    申请号：US10956040

    申请日：2004-10-04

    申请人： Takashi Emura ,  Tsuyoshi Haneishi

    发明人： Takashi Emura ,  Tsuyoshi Haneishi

    IPC分类号： C07C231/02 ,  C07C277/02 ,  C07C257/10 ,  C07C335/30 ,  C07C335/32

    CPC分类号： C07C335/32 ,  C07C231/02 ,  C07C257/14 ,  C07C257/18 ,  C07C277/02 ,  C07C233/07 ,  C07C279/18

    摘要： A synthesis method which comprises reacting NH group-containing compounds with thiocyanates, cyanamides, nitriles or esters in the presence of a silylating agent to synthesize the corresponding nitrogen-containing addition or substitution products. This method not only enables the direct and efficient synthesis of nitrogen-containing compounds including isothioureas, guanidines, amidines and amides, but it also has a wide range of applications and is suitable for large-scale synthesis.

    摘要翻译： 一种合成方法，其包括在甲硅烷基化剂存在下使含NH基的化合物与硫氰酸酯，氰胺，腈或酯反应以合成相应的含氮添加或取代产物。 该方法不仅可以直接有效地合成含氮化合物，包括异硫脲，胍，脒和酰胺，而且还具有广泛的应用范围，适用于大规模合成。

    Indolin-2-one derivatives
    19.
    发明授权
    Indolin-2-one derivatives 失效
    二氢吲哚-2-酮衍生物

    公开(公告)号：US06207836B1

    公开(公告)日：2001-03-27

    申请号：US09182490

    申请日：1998-10-30

    申请人： Toru Esaki ,  Takashi Emura ,  Eiichi Hoshino

    发明人： Toru Esaki ,  Takashi Emura ,  Eiichi Hoshino

    IPC分类号： C07D40112

    CPC分类号： C07D405/12 ,  C07D209/34 ,  C07D209/40 ,  C07D401/06 ,  C07D401/12 ,  C07D405/06

    摘要： A compound represented by formula (I): wherein R1 represents a halogen atom, a lower alkyl group, a lower alkoxy group, a hydroxyl group, a nitro group, a trifluoromethyl group, a lower alkylthio group, an acyl group, a carboxyl group, a mercapto group or an amino group; R2 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, an alkoxy group, an acyl group, an aryl group or a heterocyclic group; R3 represents a lower alkyl group, a cycloalkyl group, an aryl group, or a heterocyclic group; R4 represents a hydrogen atom, a lower alkyl group, an aryl group, a heterocyclic group, —OR5, —SR5 or —NR6R7 (wherein R5, R6, and R7 each represent a lower alkyl group, etc.); X and Y each represent —CH2—, —NH— or —O—; and n represents an integer of from 0 to 4, and an intermediate for synthesis thereof are disclosed. The compound of the present invention exhibits selective antagonism against gastrin receptors without causing side effects attributed to CCK-A receptor antagonism and is useful for the treatment and prevention of peptic ulcers, gastritis, reflux esophagitis, and Zollinger-Ellison syndrome, and for the treatment of neoplasm originating in the gastrointestinal system.

    摘要翻译： 由式（I）表示的化合物：其中R1表示卤素原子，低级烷基，低级烷氧基，羟基，硝基，三氟甲基，低级烷硫基，酰基，羧基 ，巯基或氨基; R2表示氢原子，低级烷基，低级烯基，低级炔基，烷氧基，酰基，芳基或杂环基; R3表示低级烷基，环烷基，芳基或杂环基; R4表示氢原子，低级烷基，芳基，杂环基，-OR5，-SR5或-NR6R7（其中R5，R6和R7各自表示低级烷基等）; X和Y各自表示-CH 2 - ， - NH-或-O-; 并且n表示0至4的整数，并且公开了其合成中间体。 本发明化合物对胃泌素受体表现出选择性拮抗作用，而不引起归因于CCK-A受体拮抗作用的副作用，并且可用于治疗和预防消化性溃疡，胃炎，反流性食管炎和佐林格 - 埃里森综合征，并用于治疗 的起源于胃肠系统的肿瘤。