公开(公告)号：US20090117182A1

公开(公告)日：2009-05-07

申请号：US12092852

申请日：2006-11-14

申请人： Tomoya Akutagawa ,  Masahiko Narasaki

发明人： Tomoya Akutagawa ,  Masahiko Narasaki

IPC分类号： A61K9/20 ,  A61K47/30

CPC分类号： A61K9/5026 ,  A61K9/0056 ,  A61K9/1635 ,  A61K31/131 ,  A61K31/137 ,  A61K31/375 ,  A61K31/426

摘要： The present invention provides an intraorally rapidly disintegrating tablet that can be formed using an ordinary apparatus, that has hardness with no practical problem and that disintegrates rapidly with good feeling in the oral cavity.The present invention is intraorally rapidly disintegrating tablet produced by compression molding of a granule coated with a disintegrant, in which the granule contains a disintegrant also inside thereof and a drug except ambroxol hydrochloride inside and/or outside thereof.

摘要翻译： 本发明提供一种能够使用普通装置形成的口腔内快速崩解片，其具有没有实际问题的硬度，并且在口腔中具有良好的感觉快速崩解。 本发明是通过压缩成型包覆有崩解剂的颗粒制成的口腔内快速崩解片剂，其中颗粒中还含有崩解剂，以及在其内部和/或外部含有盐酸氨溴索的药物。

公开(公告)号：US20090110726A1

公开(公告)日：2009-04-30

申请号：US12063721

申请日：2006-08-17

申请人： Masahiko Narasaki ,  Tomoya Akutagawa ,  Reiko Oku

发明人： Masahiko Narasaki ,  Tomoya Akutagawa ,  Reiko Oku

IPC分类号： A61K9/44 ,  B29C43/02

CPC分类号： A61K9/2072 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/2077 ,  A61K9/2086

摘要： The present invention provides a tablet comprising a plurality of drug-containing parts and at least one connecting part adhered to the drug-containing parts, and having a scored line capable of dividing the whole tablet on the connecting part; particularly, a coated tablet in which a connecting part and a coating layer have the same or different drug release controlling functions; a tablet having an insoluble coating on a drug-containing part having a scored line, wherein the drug-containing part has a structure or composition such that the drug is substantially released after the tablet is divided along the scored line and then ingested; and a tablet comprising a plurality of drug-containing parts and at least one connecting part adhered to the drug-containing parts, wherein at least two drug-containing parts have different compositions.In addition, the present invention provides a method of manufacturing a tablet, wherein a column comprising a plurality of columnar pharmaceutical composition layers having the same cross-section and laminated in the axial direction of the column is compression molded and then compression molded in a direction different from the axial direction of the column.

摘要翻译： 本发明提供了一种片剂，其包含多个药物含有部分和至少一个连接部分，所述至少一个连接部分粘附到所述药物包含部分，并且具有能够在所述连接部分上分割整个片剂的刻痕线; 特别是其中连接部分和涂层具有相同或不同的药物释放控制功能的包衣片剂; 在具有刻痕线的药物含有部分上具有不溶性涂层的片剂，其中所述药物含有部分具有使得所述药物在所述片剂沿着刻痕线分割然后摄取后基本上释放的结构或组成; 以及包含多个药物含有部分和至少一个粘附到所述药物含有部分的连接部分的片剂，其中至少两个药物含有部分具有不同的组成。 此外，本发明提供一种片剂的制造方法，其特征在于，将具有相同截面并在所述柱的轴向层叠的多个柱状药物组合物层的柱压缩成型，然后在 不同于柱的轴向。