-
公开(公告)号：US06911216B1
公开(公告)日：2005-06-28
申请号：US09195340
申请日：1998-11-18
CPC分类号： A61K9/0024 , A61K9/127 , Y10S514/824 , Y10S514/964 , Y10S514/965
摘要： Delivery of bioactive molecules such as nucleic acid molecules encoding a protein can be significantly enhanced by immobilization of the bioactive molecule in a polymeric material adjacent to the cells where delivery is desired, where the bioactive molecule is encapsulated in a vehicle such as liposomes which facilitates transfer of the bioactive molecules into the targeted tissue. Targeting of the bioactive molecules can also be achieved by selection of an encapsulating medium of an appropriate size whereby the medium serves to deliver the molecules to a particular target. For example, encapsulation of nucleic acid molecules or biologically active proteins within biodegradable, biocompatible polymeric microparticles which are appropriate sized to infiltrate, but remain trapped within, the capillary beds and alveoli of the lungs can be used for targeted delivery to these regions of the body following administration to a patient by infusion or injection.
摘要翻译： 通过将生物活性分子固定在与需要递送的细胞相邻的聚合物材料中，生物活性分子如编码蛋白质的核酸分子的递送可以显着增强，其中生物活性分子被包封在载体如脂质体中，这有助于转移 的生物活性分子进入靶组织。 生物活性分子的靶向也可以通过选择合适尺寸的包封介质来实现，由此介质用于将分子递送到特定靶。 例如，将核酸分子或生物活性蛋白质包封在可生物降解的生物相容性聚合物微粒中，其适当尺寸以渗透，但仍被捕获在肺的毛细血管床和肺泡内，可用于靶向递送至身体的这些区域 之后通过输注或注射给予患者。
-
公开(公告)号：US5879713A
公开(公告)日：1999-03-09
申请号：US787647
申请日：1997-01-23
CPC分类号： A61K9/0024 , A61K9/127 , Y10S514/824 , Y10S514/964 , Y10S514/965
摘要： Delivery of bioactive molecules such as nucleic acid molecules encoding a protein can be significantly enhanced by immobilization of the bioactive molecule in a polymeric material adjacent to the cells where delivery is desired, where the bioactive molecule is encapsulated in a vehicle such as liposomes which facilitates transfer of the bioactive molecules into the targeted tissue. Targeting of the bioactive molecules can also be achieved by selection of an encapsulating medium of an appropriate size whereby the medium serves to deliver the molecules to a particular target. For example, encapsulation of nucleic acid molecules or biologically active proteins within biodegradable, biocompatible polymeric microparticles which are appropriate sized to infiltrate, but remain trapped within, the capillary beds and alveoli of the lungs can be used for targeted delivery to these regions of the body following administration to a patient by infusion or injection.
摘要翻译： 通过将生物活性分子固定在与需要递送的细胞相邻的聚合物材料中，生物活性分子如编码蛋白质的核酸分子的递送可以显着增强，其中生物活性分子被包封在载体如脂质体中，这有助于转移 的生物活性分子进入靶组织。 生物活性分子的靶向也可以通过选择合适尺寸的包封介质来实现，由此介质用于将分子递送到特定靶。 例如，将核酸分子或生物活性蛋白质包封在可生物降解的生物相容性聚合物微粒中，其适当尺寸以渗透，但仍被捕获在肺的毛细血管床和肺泡内，可用于靶向递送至身体的这些区域 通过输注或注射给予患者。
-
搜索结果
12 条记录 (耗时 0.036 秒)
