SYSTEMS AND METHODS FOR MYOPIC ESTIMATION OF NUCLEIC ACID BINDING

    公开(公告)号:US20240153582A1

    公开(公告)日:2024-05-09

    申请号:US17940838

    申请日:2022-09-08

    IPC分类号: G16B30/00

    CPC分类号: G16B30/00

    摘要: Systems and methods for capturing desired interactions and non-interactions of a set of strands (e.g., DNA strands, RNA strands) that may be used in various technological applications, including DNA molecular probes used in medical diagnostics, forensics, microbial ecology, molecular computation, DNA origami, and numerous other applications. Given a nucleic acid system with a certain defined binding pattern, the implementations of the present disclosure automatically generate nucleotide sequences that achieve the intended binding pattern and not other binding patterns, subject to miscellaneous other constraints of the system. Advantageously, given nucleotides i and j, the implementations of the present disclosure consider the binding behavior only in a limited neighborhood of nucleotides surrounding each nucleotide in their respective strands, rather than the binding behavior of whole assignment of which they are a part. These features provide a time-efficient and incremental algorithm that is suitable for numerous practical applications.

    Transactional file system
    12.
    发明授权
    Transactional file system 有权
    事务文件系统

    公开(公告)号:US08510336B2

    公开(公告)日:2013-08-13

    申请号:US13181703

    申请日:2011-07-13

    IPC分类号: G06F17/30

    摘要: A transactional file system wherein multiple file system operations may be performed as a transaction. An application specifies that file system-related operations are to be handled as a transaction, and the application is given a file handle associated with a transaction context. For file system requests associated with a transaction context, a file system component manages operations consistent with transactional behavior. Logging and recovery are also facilitated by logging page data separate from the main log with a unique signature that enables the log to determine whether a page was fully flushed to disk prior to a system crash.

    摘要翻译: 一种事务文件系统,其中可以执行多个文件系统操作作为事务。 应用程序指定文件系统相关操作将作为一个事务来处理,并且应用程序被赋予与事务上下文相关联的文件句柄。 对于与事务上下文相关联的文件系统请求,文件系统组件管理与事务行为一致的操作。 通过使用独特的签名将与主日志分开的页面数据记录在一起,从而使日志能够在系统崩溃之前确定页面是否完全刷新到磁盘,从而方便了日志记录和恢复。

    Transactional file system
    13.
    发明授权
    Transactional file system 有权
    事务文件系统

    公开(公告)号:US06856993B1

    公开(公告)日:2005-02-15

    申请号:US09539233

    申请日:2000-03-30

    IPC分类号: G06F12/00 G06F17/30

    摘要: A transactional file system wherein multiple file system operations may be performed as transaction. An application specifies that file system-related operations should be handled in a transaction, and is given a file handle associated with a transaction context. For file system requests associated with a transaction context, a file system component manages operations consistent with transactional behavior. The component provides data isolation by providing multiple file versions such that transactional readers do not receive changes until after the transaction commits and the reader reopens the file. The component handles namespace logging operations in a multiple-level log that facilitates logging and recovery. Page data is logged separate from the main log, with signatures establishing whether pages were fully flushed to disk. Namespace isolation via isolation directories allows a transaction to see its operational effects but not effects of other uncommitted transactions. Transactions over a network are facilitated.

    摘要翻译: 可以作为事务执行多个文件系统操作的事务文件系统。 一个应用程序指定文件系统相关的操作应该在事务中处理,并且被赋予与事务上下文关联的文件句柄。 对于与事务上下文相关联的文件系统请求,文件系统组件管理与事务行为一致的操作。 该组件通过提供多个文件版本来提供数据隔离,以便在事务提交之后事务读取器不会接收更改,并且读取器重新打开该文件。 该组件处理多级日志中的命名空间日志记录操作,便于记录和恢复。 页面数据与主日志分开记录,签名确定页面是否完全刷新到磁盘。 通过隔离目录命名空间隔离允许事务查看其操作效果,但不影响其他未提交的事务。 通过网络进行的交易是便利的。

    Data transfer utilizing single functionally independent data transfer mechanism
    14.
    发明授权
    Data transfer utilizing single functionally independent data transfer mechanism 失效
    数据传输利用单一功能独立的数据传输机制

    公开(公告)号:US06721951B1

    公开(公告)日:2004-04-13

    申请号:US09258039

    申请日:1999-02-25

    IPC分类号: G06F946

    CPC分类号: G06F9/543

    摘要: An improved data transfer mechanism is provided. In a preferred embodiment of the present invention, a uniform data transfer mechanism is used by each computer program performing data transfer. The uniform data transfer mechanism of the preferred embodiment of the present invention provides a communication mechanism and a flexible and robust interface to support all existing and future data transfer applications.

    摘要翻译: 提供了一种改进的数据传输机制。 在本发明的优选实施例中,每个执行数据传输的计算机程序使用统一的数据传送机制。 本发明的优选实施例的统一数据传输机制提供了一种通信机制以及灵活和可靠的接口,以支持所有现有和将来的数据传输应用。

    Method and system for network marshalling of interface pointers for
remote procedure calls
    17.
    发明授权
    Method and system for network marshalling of interface pointers for remote procedure calls 失效
    用于远程过程调用的接口指针的网络编组方法和系统

    公开(公告)号:US5511197A

    公开(公告)日:1996-04-23

    申请号:US158627

    申请日:1993-11-29

    摘要: A computer method and system for passing a pointer to an interface from a server process to a client process. In a preferred embodiment, the server process instantiates an object that has multiple interfaces. The server process identifies an interface to pass to the client process and creates a stub object for receiving a request to invoke a function member of the interface and for invoking the requested function member upon receiving the request. The server process then sends an identifier of the stub to the client process. When the client process receives the identifier of the stub, it instantiates a proxy object for receiving requests to invoke a function member of the interface and for sending the request to the identified stub. The client process can then invoke the function members of the interface by invoking function members of the proxy object. The proxy object sends a request to the identified stub. The identified stub then invokes the corresponding function member of the interface.

    摘要翻译: 一种用于将指针从服务器进程传递到客户端进程的计算机方法和系统。 在优选实施例中,服务器进程实例化具有多个接口的对象。 服务器进程标识要传递给客户端进程的接口,并创建一个存根对象,用于接收调用接口的功能成员的请求,并在接收到请求时调用所请求的函数成员。 然后,服务器进程将存根的标识符发送到客户端进程。 当客户端进程接收存根的标识符时,它实例化一个代理对象,用于接收请求以调用该接口的一个功能成员,并将该请求发送到已识别的存根。 客户端进程可以通过调用代理对象的函数成员来调用接口的函数成员。 代理对象向已识别的存根发送请求。 识别的存根然后调用接口的相应功能成员。

    Transactional file system
    18.
    发明授权
    Transactional file system 有权
    事务文件系统

    公开(公告)号:US07418463B2

    公开(公告)日:2008-08-26

    申请号:US11010820

    申请日:2004-12-13

    IPC分类号: G06F17/30

    摘要: A transactional file system wherein multiple file system operations may be performed as a transaction. An application specifies that file system-related operations are to be handled as a transaction, and the application is given a file handle associated with a transaction context. For file system requests associated with a transaction context, a file system component manages the operations consistent with transactional behavior. The component provides data isolation by providing multiple versions of a file by tracking copies of changed pages, such that transactional readers do not receive changes to a file made by transactional writers, until the transactional writer commits the transaction and the reader reopens the file. The component handles namespace logging operations in a multiple-level log that facilitates logging and recovery. Page data is logged separate from the main log, with a unique signature that enables the log to determine whether a page was fully flushed to disk.

    摘要翻译: 一种事务文件系统,其中可以执行多个文件系统操作作为事务。 应用程序指定文件系统相关操作将作为一个事务来处理,并且应用程序被赋予与事务上下文相关联的文件句柄。 对于与事务上下文相关联的文件系统请求,文件系统组件管理与事务行为一致的操作。 该组件通过跟踪更改的页面的副本来提供文件的多个版本来提供数据隔离,以便事务性读取器不会接收事务写入器所做的文件的更改,直到事务写入程序提交事务并且读取器重新打开该文件。 该组件处理多级日志中的命名空间日志记录操作,便于记录和恢复。 页面数据与主日志分开记录,具有唯一的签名,可使日志确定页面是否已完全刷新到磁盘。

    Method and system for naming and binding objects

    公开(公告)号:US07150024B2

    公开(公告)日:2006-12-12

    申请号:US10283627

    申请日:2002-10-29

    IPC分类号: G06F9/46

    摘要: A method and system for referring to and binding to objects using a moniker object is provided. In a preferred embodiments moniker object contains information to identify linked source data and provides methods through which a program can bind to the linked source data. A binding method is provided that returns an instance of an interface through which the linked source data can be accessed. The moniker object can identify source data that is stored persistently or nonpersistently. In addition, moniker objects can be composed to form a composite moniker object. A composite moniker object is used to identify linked source data that is nested in other data. In a preferred embodiment, the moniker object provides other methods including a reducing method that returns a more efficient representation of the moniker object; equality and hash methods for comparing moniker objects; and inverse, common prefix, and relative-path-to methods for comparing and locating moniker objects from other moniker objects. Several implementations of a moniker object are provided including a file moniker, an item moniker, a generic composite moniker, a pointer moniker, and an anti moniker. Each implementation is a moniker class and has a class identifier that identifies code to manage the moniker class.

    Method and system for caching presentation data
    20.
    发明授权
    Method and system for caching presentation data 失效
    缓存表示数据的方法和系统

    公开(公告)号:US06708196B1

    公开(公告)日:2004-03-16

    申请号:US09461640

    申请日:1999-12-14

    IPC分类号: G06F900

    CPC分类号: G06F12/0875

    摘要: A method and system for retrieving and maintaining presentation data in a presentation cache is provided. In a preferred embodiment, a presentation cache object provides a presentation cache with multiple cache entries. Each entry contains an indication of the format of the presentation data and the presentation data stored in that particular format. In addition, other information, such as the advisees of advisory connections for notification of cache updates, can be maintained. The presentation cache object responds to requests for retrieving source object data by returning presentation data cached within the presentation cache when it is available. In addition, the presentation cache object determines when it should delegate requests to the source object and when it can satisfy them on its own. The presentation cache object can return presentation data to a requesting client program even if the server program implementing the source object is unavailable or not running. The presentation cache object can also choose to persistently store its cache entries so that the presentation cache is maintained when the source object is closed. In addition, client programs can provide control over the frequency and subject of presentation data updates within the presentation cache.

    摘要翻译: 提供了一种用于在呈现高速缓存中检索和维护呈现数据的方法和系统。 在优选实施例中,呈现高速缓存对象提供具有多个高速缓存条目的呈现缓存。 每个条目包含以该特定格式存储的呈现数据和呈现数据的格式的指示。 此外,可以保持其他信息,例如用于缓存更新通知的咨询连接的建议。 呈现缓存对象响应于通过在显示高速缓存中缓存的呈现数据可用时返回呈现数据来检索源对象数据。 此外,演示缓存对象确定何时应该将请求委托给源对象,何时可以自己满足它们。 即使实现源对象的服务器程序不可用或不运行,呈现缓存对象也可以将呈现数据返回给请求客户端程序。 演示缓存对象还可以选择持久存储其缓存条目,以便在源对象关闭时保持演示缓存。 此外,客户端程序可以提供对呈现数据更新的频率和主题的控制。