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公开(公告)号:US07462629B2
公开(公告)日:2008-12-09
申请号:US10849450
申请日:2004-05-19
申请人: Shifeng Pan , Nathanael S. Gray , Yuan Mi , Yi Fan , Wenqi Gao
发明人: Shifeng Pan , Nathanael S. Gray , Yuan Mi , Yi Fan , Wenqi Gao
IPC分类号: A61K31/4725 , A61K31/4035 , A61K31/397 , C07D217/12 , C07D209/44 , C07D205/12
CPC分类号: C07C323/32 , C07C317/32 , C07C2601/14 , C07D205/04
摘要: The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
摘要翻译: 本发明涉及免疫抑制剂,其生产方法及其用途和含有它们的药物组合物。 本发明提供了一类新颖的化合物,其可用于治疗或预防由淋巴细胞相互作用介导的疾病或病症,特别是与EDG受体介导的信号转导相关的疾病。
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公开(公告)号:US08101608B2
公开(公告)日:2012-01-24
申请号:US11718886
申请日:2005-11-07
申请人: Yongqin Wan , Yuan Mi , Yi Fan , Dai Cheng , Yi Liu , Nathanael S. Gray , Pamela Albaugh
发明人: Yongqin Wan , Yuan Mi , Yi Fan , Dai Cheng , Yi Liu , Nathanael S. Gray , Pamela Albaugh
IPC分类号: A61K31/404 , A61K31/4025 , A61K31/4178 , A61K31/4245 , A61K31/454 , A61K31/5377 , A61K31/496 , C07D401/14 , C07D403/14 , C07D405/06 , C07D405/14 , C07D413/06 , C07D413/14 , C07D471/04
CPC分类号: C07D403/14 , C07D403/06
摘要: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, Bcr-Abl, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, Axl, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC, Raf, ROCK-II, Rsk1, SGK, TrkA, TrkB and TrkC kinases.
摘要翻译: 本发明提供了一类新颖的化合物,包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法,特别是涉及Abl,Bcr-Abl异常活化的疾病或病症 ,cSrc,TPR-Met,Tie2,MET,FGFR3,Aurora,Ax1,Bmx,BTK,c-kit,CHK2,Flt3,MST2,p70S6K,PDGFR,PKB,PKC,Raf,ROCK-II,Rsk1,SGK,TrkA ,TrkB和TrkC激酶。
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公开(公告)号:US07939519B2
公开(公告)日:2011-05-10
申请号:US12024992
申请日:2008-02-01
申请人: Shifeng Pan , Wenqi Gao , Nathanael S Gray , Yuan Mi , Yi Fan
发明人: Shifeng Pan , Wenqi Gao , Nathanael S Gray , Yuan Mi , Yi Fan
IPC分类号: A61K31/397 , C07D205/00
CPC分类号: C07D205/04 , C07C251/48 , C07C251/52 , C07C251/54 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D207/16 , C07D211/60 , C07D213/30 , C07D213/53 , C07D213/61 , C07D217/04 , C07D295/06 , C07D307/10 , C07D307/12 , C07D307/52 , C07D333/12 , C07D333/16 , C07D333/22
摘要: The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
摘要翻译: 本发明涉及免疫抑制剂,其生产方法及其用途和含有它们的药物组合物。 本发明提供了一类新颖的化合物,其可用于治疗或预防由淋巴细胞相互作用介导的疾病或病症,特别是与EDG受体介导的信号转导相关的疾病。
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公开(公告)号:US07718704B2
公开(公告)日:2010-05-18
申请号:US10590606
申请日:2005-02-24
申请人: Shifeng Pan , Wenqi Gao , Nathanael Schiander Gray , Yuan Mi
发明人: Shifeng Pan , Wenqi Gao , Nathanael Schiander Gray , Yuan Mi
IPC分类号: C07C251/50 , C07D311/68 , C07D241/04 , C07D215/40 , C07D205/04 , A61K31/15 , A61K31/197 , A61K31/353 , A61K31/397 , A61K31/4704 , A61K31/495
CPC分类号: C07D311/68 , C07C251/52 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D205/04 , C07D215/40 , C07D295/15 , C07D401/06 , C07D405/06 , C07D491/04 , C07D491/052
摘要: The invention provides a novel class of cyclic oximes of Formula I: wherein A, X, Y, Z, W, R1, R2, R3 and n are as described in the summary of the invention; useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
摘要翻译: 本发明提供式I的新一类环状肟:其中A,X,Y,Z,W,R 1,R 2,R 3和n如本发明概述所述; 可用于治疗或预防由淋巴细胞相互作用介导的疾病或病症,特别是与EDG受体介导的信号转导相关的疾病。
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公开(公告)号:US20100087464A1
公开(公告)日:2010-04-08
申请号:US12443626
申请日:2007-08-27
申请人: Yuan Mi , Pamela A. Albaugh
发明人: Yuan Mi , Pamela A. Albaugh
IPC分类号: A61K31/505 , C07D249/08 , A61K31/4196 , C12N5/00 , C07D401/14 , A61K31/454 , A61K31/4439 , C07D403/14 , A61K31/4178 , C07D235/04 , A61K31/4184 , C07D271/06 , A61K31/4245 , A61P35/00 , A61P29/00 , A61P3/10 , A61P37/04
CPC分类号: C07D403/14 , C07D405/14 , C07D413/14
摘要: The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, and methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of TrkA, TrkB, TrkC, Abl, Bcr-Abl, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, Axl, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKCα, Raf, ROCK-II, Rsk1, and SGK kinases, or a combination thereof.
摘要翻译: 本发明提供了可用作蛋白激酶抑制剂的化合物及其药物组合物,以及使用这些化合物治疗,改善或预防与异常或失调的激酶活性相关的病症的方法。 在一些实施方案中,本发明提供了使用这些化合物治疗,改善或预防涉及TrkA,TrkB,TrkC,Abl,Bcr-Abl,cSrc,TPR-Met,Tie2,MET,FGFR3等的异常活化的疾病或病症的方法。 Aurora,Axl,Bmx,BTK,c-kit,CHK2,Flt3,MST2,p70S6K,PDGFR,PKB,PKCα,Raf,ROCK-II,Rsk1和SGK激酶,或其组合。
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公开(公告)号:US07572811B2
公开(公告)日:2009-08-11
申请号:US10590618
申请日:2005-02-24
申请人: Shifeng Pan , Thomas Marsilje , Wenshuo Lu , Wenqi Gao , Nathanael Schiander Gray , Yun He , Yahua Liu , Yuan Mi , Yongping Xie
发明人: Shifeng Pan , Thomas Marsilje , Wenshuo Lu , Wenqi Gao , Nathanael Schiander Gray , Yun He , Yahua Liu , Yuan Mi , Yongping Xie
IPC分类号: A61K31/445 , C07D211/30
CPC分类号: C07D401/04 , C07D205/04 , C07D207/08 , C07D207/12 , C07D211/22 , C07D213/74 , C07D237/22 , C07D239/46 , C07D295/108 , C07D295/15 , C07D401/06 , C07D403/04 , C07D403/06 , C07D409/04 , C07D409/12 , C07D413/10 , C07D417/10
摘要: The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
摘要翻译: 本发明涉及免疫抑制剂,其生产方法及其用途和含有它们的药物组合物。 本发明提供了一类新颖的化合物,其可用于治疗或预防由淋巴细胞相互作用介导的疾病或病症,特别是与EDG受体介导的信号转导相关的疾病。
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公开(公告)号:US07417065B2
公开(公告)日:2008-08-26
申请号:US10849458
申请日:2004-05-19
申请人: Yuan Mi , Shifeng Pan , Nathanael Schiander Gray , Wenqi Gao , Yi Fan , Tao Jiang
发明人: Yuan Mi , Shifeng Pan , Nathanael Schiander Gray , Wenqi Gao , Yi Fan , Tao Jiang
IPC分类号: A61K31/381 , C07D333/62
CPC分类号: C07D333/58 , C07D261/20 , C07D409/06 , C07D471/04 , C07D473/00 , C07D513/04
摘要: The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
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公开(公告)号:US20070203100A1
公开(公告)日:2007-08-30
申请号:US10590618
申请日:2005-02-24
申请人: Shifeng Pan , Thomas Marsilje , Wenshuo Lu , Gao Wenqi , Nathanael Gray , Yun He , Yahua Liu , Yuan Mi , Yongping Xie
发明人: Shifeng Pan , Thomas Marsilje , Wenshuo Lu , Gao Wenqi , Nathanael Gray , Yun He , Yahua Liu , Yuan Mi , Yongping Xie
IPC分类号: A61K31/675 , A61K31/495 , A61K31/454 , A61K31/453 , A61K31/40
CPC分类号: C07D401/04 , C07D205/04 , C07D207/08 , C07D207/12 , C07D211/22 , C07D213/74 , C07D237/22 , C07D239/46 , C07D295/108 , C07D295/15 , C07D401/06 , C07D403/04 , C07D403/06 , C07D409/04 , C07D409/12 , C07D413/10 , C07D417/10
摘要: The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
摘要翻译: 本发明涉及免疫抑制剂,其生产方法及其用途和含有它们的药物组合物。 本发明提供了一类新颖的化合物,其可用于治疗或预防由淋巴细胞相互作用介导的疾病或病症,特别是与EDG受体介导的信号转导相关的疾病。
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公开(公告)号:US07750021B2
公开(公告)日:2010-07-06
申请号:US12180479
申请日:2008-07-25
申请人: Yuan Mi , Shifeng Pan , Nathanael Schiander Gray , Wenqi Gao , Yi Fan , Tao Jiang
发明人: Yuan Mi , Shifeng Pan , Nathanael Schiander Gray , Wenqi Gao , Yi Fan , Tao Jiang
IPC分类号: A61K31/343 , A61K31/352 , A61K31/396 , A61K31/4035 , A61K31/404 , A61K31/416 , A61K31/423 , A61K31/428 , A61K31/4365 , A61K31/437 , C07D263/56 , C07D277/64 , C07D231/56 , C07D209/04 , C07D513/04 , C07D493/04
CPC分类号: C07D333/58 , C07D261/20 , C07D409/06 , C07D471/04 , C07D473/00 , C07D513/04
摘要: The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
摘要翻译: 本发明涉及免疫抑制剂,其生产方法及其用途和含有它们的药物组合物。 本发明提供了一类新颖的化合物,其可用于治疗或预防由淋巴细胞相互作用介导的疾病或病症,特别是与EDG受体介导的信号转导相关的疾病。
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公开(公告)号:US20100168182A1
公开(公告)日:2010-07-01
申请号:US12518831
申请日:2007-12-11
申请人: Yuan Mi , Pamela Albaugh , Yi Fan , Ha-Soon Choi , Zuosheng Liu , Shenlin Huang
发明人: Yuan Mi , Pamela Albaugh , Yi Fan , Ha-Soon Choi , Zuosheng Liu , Shenlin Huang
IPC分类号: A61K31/404 , A61K31/4439 , A61K31/427 , A61K31/422 , A61K31/4178 , A61K31/4155 , C07D401/14 , C07D417/14 , C07D413/14 , C07D403/14 , C07D403/06 , A61P35/00 , C07D405/14
CPC分类号: C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D413/14
摘要: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly TrkA, TrkB, TrkC, PDGFR and c-kit.
摘要翻译: 本发明提供了一类新颖的化合物,包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法,特别是TrkA,TrkB,TrkC,PDGFR和c-kit。
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