公开(公告)号：US4448725A

公开(公告)日：1984-05-15

申请号：US407790

申请日：1982-08-13

申请人： Wolfgang Preuss

发明人： Wolfgang Preuss

IPC分类号： C07J9/00 ,  C07J41/00

CPC分类号： C07J9/005 ,  C07J41/0061

摘要： New .DELTA.4-steroid compounds optionally containing a further double bond in the 1-position and an 11-oxygen function and corresponding to general formula I below: ##STR1## in which X represents halogen, particularly chlorine or bromine, or NH.sub.2 and Y is a hydroxyl group, or together with the C-atom substituted by Y, represents a carbonyl group, are obtained from the associated steroid-20-carboxylic acids by reaction with a halogenating agent in substantially stoichiometric quantities at temperatures not exceeding 15.degree. C., after which the steroid-20-carboxylic acid halide formed is, if desired, reacted with ammonia or with a compound which yields ammonia.

摘要翻译： 新的DELTA 4-类固醇化合物，其任选地在1-位上含有另外的双键和11-氧官能团，并且对应于下面的通式I：其中X表示卤素，特别是氯或溴或NH 2 Y为羟基，或与Y取代的C原子一起代表羰基，可以通过与卤化剂以相当于化学计量的量在不超过15℃的条件下与卤化剂反应而得自相关的类固醇-20-羧酸 然后，如果需要，形成的类固醇-20-羧酸卤化物与氨或产生氨的化合物反应。