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公开(公告)号:US06280735B1
公开(公告)日:2001-08-28
申请号:US09369700
申请日:1999-08-06
申请人: Michael Terence Black , Martin Karl Russell Burnham , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M Pratt , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Judith M Ward , Richard Lloyd Warren
发明人: Michael Terence Black , Martin Karl Russell Burnham , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M Pratt , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Judith M Ward , Richard Lloyd Warren
IPC分类号: A61K3902
CPC分类号: C12N9/0036 , A61K38/00 , A61K39/00 , C07K14/31 , C07K16/1275 , C07K2319/00 , C12N9/78 , C12N15/52 , C12Q1/689 , C12Q2600/158 , C12Y105/0103 , C12Y305/04025
摘要: The invention provides ribG polypeptides and polynucleotides encoding ribG polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribG polypeptides to screen for antibacterial compounds.
摘要翻译: 本发明提供ribG多肽和编码ribG多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用ribG多肽筛选抗菌化合物的方法。
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公开(公告)号:US6010881A
公开(公告)日:2000-01-04
申请号:US978456
申请日:1997-11-25
申请人: Michael Terence Black , Martin Karl Russell Burnham , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M Pratt , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Judith M Ward , Richard Lloyd Warren
发明人: Michael Terence Black , Martin Karl Russell Burnham , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M Pratt , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Judith M Ward , Richard Lloyd Warren
IPC分类号: G01N33/53 , A61K38/00 , A61K39/00 , A61K39/02 , A61K39/395 , A61K48/00 , A61P31/00 , A61P31/04 , C07K14/31 , C07K16/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/02 , C12N9/78 , C12N15/09 , C12N15/52 , C12Q1/68 , C12P21/06 , C07H21/04 , C12N1/20 , C12N15/00
CPC分类号: C12N9/0036 , C07K14/31 , C07K16/1275 , C12N15/52 , C12N9/78 , C12Q1/689 , C12Y105/0103 , C12Y305/04025 , A61K38/00 , A61K39/00 , C07K2319/00 , C12Q2600/158
摘要: The invention provides ribG polypeptides and polynucleotides encoding ribG polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribG polypeptides to screen for antibacterial compounds.
摘要翻译: 本发明提供ribG多肽和编码ribG多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用ribG多肽筛选抗菌化合物的方法。
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公开(公告)号:US06171598B2
公开(公告)日:2001-01-09
申请号:US09225967
申请日:1999-01-06
申请人: Min Wang , Judith M Ward , Richard Lloyd Warren , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M Pratt , David Justin Charles Knowles , Michael Arthur Lonetto , Jeffrey Mooney , Michael Terence Black , Martin Karl Russell Burnham , Christine Debouck , Jason Craig Fedon , John Edward Hodgson , Deborah Dee Jaworski , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Yi Yi Zhong
发明人: Min Wang , Judith M Ward , Richard Lloyd Warren , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M Pratt , David Justin Charles Knowles , Michael Arthur Lonetto , Jeffrey Mooney , Michael Terence Black , Martin Karl Russell Burnham , Christine Debouck , Jason Craig Fedon , John Edward Hodgson , Deborah Dee Jaworski , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Yi Yi Zhong
IPC分类号: A61K3850
CPC分类号: C12Y305/04025 , C07K2319/00 , C12N9/78
摘要: The invention provides ribA polypeptides and polynucleotides encoding ribA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribA polypeptides to screen for antibacterial compounds.
摘要翻译: 本发明提供ribA多肽和编码ribA多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用ribA多肽筛选抗菌化合物的方法。
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公开(公告)号:US06348578B1
公开(公告)日:2002-02-19
申请号:US09417511
申请日:1999-10-14
申请人: Michael Arthur Lonetto , Richard Oakley Nicholas , James Raymond Brown , Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Robert King Stodola , Magdalena Zalacain
发明人: Michael Arthur Lonetto , Richard Oakley Nicholas , James Raymond Brown , Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Robert King Stodola , Magdalena Zalacain
IPC分类号: C07K100
CPC分类号: C07K14/3156 , A61K38/00 , A61K39/00 , C12N9/1077 , C12N9/1205 , C12N9/78 , C12N9/80 , C12Y207/01002 , Y10S530/825
摘要: The invention provides apt polypeptides and DNA (RNA) encoding apt polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing apt polypeptides to screen for antibacterial compounds.
摘要翻译: 本发明提供了适应多肽和编码适应多肽的DNA(RNA),以及通过重组技术产生此类多肽的方法。 还提供了利用适当多肽筛选抗菌化合物的方法。
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15.DNA encoding adenine phosphoribosyltransferase from Streptococcus pneumoniae 失效
标题翻译: 从肺炎链球菌编码腺嘌呤磷酸核糖基转移酶的DNA公开(公告)号:US06165762A
公开(公告)日:2000-12-26
申请号:US958668
申请日:1997-10-27
申请人: Michael Arthur Lonetto , Richard Oakley Nicholas , James Raymond Brown , David Justin Charles Knowles , Michael Terence Black , John Edward Hodgson , Robert King Stodola , Magdalena Zalacain
发明人: Michael Arthur Lonetto , Richard Oakley Nicholas , James Raymond Brown , David Justin Charles Knowles , Michael Terence Black , John Edward Hodgson , Robert King Stodola , Magdalena Zalacain
IPC分类号: C12N15/09 , A61K31/00 , A61K31/70 , A61K38/00 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P31/00 , A61P31/04 , C07K14/315 , C07K16/12 , C12N1/21 , C12N9/10 , C12N9/12 , C12N9/78 , C12N9/80 , C12N15/00 , C12N15/54 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/46 , G01N33/50 , C07H21/04 , C12N1/20
CPC分类号: C07K14/3156 , A61K38/00 , A61K39/00 , C12N9/1077 , C12N9/1205 , C12N9/78 , C12N9/80 , C12Y207/01002 , Y10S530/825
摘要: The invention provides apt polypeptides and DNA (RNA) encoding apt polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing apt polypeptides to screen for antibacterial compounds.
摘要翻译: 本发明提供了适应多肽和编码适应多肽的DNA(RNA),以及通过重组技术产生此类多肽的方法。 还提供了利用适当多肽筛选抗菌化合物的方法。
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公开(公告)号:US06287803B1
公开(公告)日:2001-09-11
申请号:US08965130
申请日:1997-11-06
申请人: Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard Oakley Nicholas , Leslie Marie Palmer , Robert H. Reid , Martin Rosenberg , Phillip Zarfos
发明人: Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard Oakley Nicholas , Leslie Marie Palmer , Robert H. Reid , Martin Rosenberg , Phillip Zarfos
IPC分类号: C12N1531
CPC分类号: G01N33/68 , A61K38/00 , A61K39/00 , C07K14/3156 , C07K2319/00 , G01N2333/315
摘要: The invention provides era polypeptides and DNA (RNA) encoding era polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing era polypeptides to screen for antibacterial compounds.
摘要翻译: 本发明提供了编码时代多肽的时代多肽和DNA(RNA),以及通过重组技术产生此类多肽的方法。 还提供了利用时代多肽筛选抗菌化合物的方法。
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公开(公告)号:US06348328B1
公开(公告)日:2002-02-19
申请号:US08858207
申请日:1997-05-14
申请人: Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Richard Oakley Nicholas , Robert King Stodola
发明人: Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Richard Oakley Nicholas , Robert King Stodola
IPC分类号: C12P2102
CPC分类号: C07K14/3156 , C07K2319/00
摘要: This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the uses of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides and recombinant host cells transformed with the polynucleotides. This invention also relates to inhibiting the biosynthesis or action of such polynucleotides or polypeptides and to the use of such inhibitors in therapy.
摘要翻译: 本发明涉及新鉴定的多核苷酸,由这些多核苷酸编码的多肽,这种多核苷酸和多肽的用途,以及这些多核苷酸和多肽的产生以及用多核苷酸转化的重组宿主细胞。 本发明还涉及抑制这些多核苷酸或多肽的生物合成或作用以及这种抑制剂在治疗中的用途。
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公开(公告)号:US06323336B1
公开(公告)日:2001-11-27
申请号:US09322081
申请日:1999-05-28
申请人: Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard Oakley Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
发明人: Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard Oakley Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
IPC分类号: C07H2104
CPC分类号: C07K14/31 , A61K39/00 , C07K16/1275 , C12N9/78 , C12Y305/04025
摘要: The invention provides phoH homolog polypeptides and DNA (RNA) encoding phoH homolog polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing phoH homolog polypeptides to screen for antibacterial compounds.
摘要翻译: 本发明提供phoH同系物多肽和编码phoH同源多肽的DNA(RNA),以及通过重组技术产生此类多肽的方法。 还提供了利用phoH同源多肽筛选抗菌化合物的方法。
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公开(公告)号:US06248863B1
公开(公告)日:2001-06-19
申请号:US09343986
申请日:1999-06-29
申请人: Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard Oakley Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
发明人: Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard Oakley Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
IPC分类号: C07K500
CPC分类号: C07K14/31 , A61K39/00 , C07K16/1275 , C12N9/78 , C12Y305/04025
摘要: The invention provides phoH homolog polypeptides and DNA (RNA) encoding phoH homolog polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing phoH homolog polypeptides to screen for anitbacterial compounds.
摘要翻译: 本发明提供phoH同系物多肽和编码phoH同源多肽的DNA(RNA),以及通过重组技术产生此类多肽的方法。 还提供了利用phoH同系物多肽来筛选脱细菌化合物的方法。
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公开(公告)号:US5885805A
公开(公告)日:1999-03-23
申请号:US915107
申请日:1997-08-20
申请人: Michael Arthur Lonetto , Patrick Vernon Warren , Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard Oakley Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward
发明人: Michael Arthur Lonetto , Patrick Vernon Warren , Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard Oakley Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward
IPC分类号: G01N33/50 , A61K31/70 , A61K38/00 , A61K38/04 , A61K38/44 , A61K38/55 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P31/04 , A61P35/00 , A61P37/00 , A61P37/04 , A61P43/00 , C07K14/31 , C07K16/12 , C12N1/00 , C12N1/21 , C12N9/00 , C12N9/04 , C12N9/12 , C12N9/14 , C12N9/88 , C12N15/00 , C12N15/09 , C12N15/31 , C12N15/53 , C12N15/54 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , C12R1/19 , C12R1/44 , C12R1/445 , G01N33/15 , G01N33/53 , G01N33/569 , G01N33/573 , C12P21/04 , C12N15/63
CPC分类号: C12N9/0006 , C07K14/31 , C12N9/00 , C12N9/1205 , C12N9/88 , A61K38/00 , A61K39/00 , C07K2319/00 , Y10S435/883
摘要: The invention provides gbpA polypeptides and DNA (RNA) encoding gbpA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing gbpA polypeptides to screen for antibacterial compounds.
摘要翻译: 本发明提供了gbpA多肽和编码gbpA多肽的DNA(RNA),以及通过重组技术产生此类多肽的方法。 还提供了利用gbpA多肽筛选抗菌化合物的方法。
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