公开(公告)号：US20230081530A1

公开(公告)日：2023-03-16

申请号：US17275832

申请日：2019-09-13

Applicant: ModernaTX, Inc.

Inventor： Joshua FREDERICK ,  Sushma GURUMURTHY ,  Ankita MISHRA ,  Ailin BAI

IPC: A61K31/7105 ,  A61K9/51 ,  A61K38/17 ,  A61K39/395 ,  A61K38/20 ,  A61P35/00 ,  A61P35/02

Abstract: The disclosure features methods for treating cancer, including solid tumors and disseminated cancers such as myeloid malignancies, using one or more mRNAs encoding an OX40L polypeptide, an IL-12 polypeptide, an IL-15 polypeptide, and combinations thereof.

公开(公告)号：US20230041964A1

公开(公告)日：2023-02-09

申请号：US17826387

申请日：2022-05-27

Applicant: ModernaTX, Inc.

Inventor： Joshua FREDERICK ,  Ailin BAI ,  Vladimir PRESNYAK ,  Stephen HOGE ,  Kerry BENENATO ,  Iain MCFADYEN ,  Ellalahewage Sathyajith KUMARASINGHE ,  Susannah HEWITT

IPC: A61K9/51 ,  A61K48/00 ,  A61K38/17 ,  A61K38/20 ,  A61K9/00 ,  A61K39/39 ,  A61K45/06 ,  A61K9/127 ,  C07K14/54 ,  C07K14/545 ,  C07K14/705 ,  A61K31/7088 ,  A61K31/7115 ,  A61P35/00 ,  A61K39/395

Abstract: The disclosure relates to compositions and methods for the preparation, manufacture and therapeutic use of combinations of immunomodulatory polynucleotides (e.g., mRNAs) encoding an immune response primer polypeptide (e.g., an interleukin 23 (IL-23) polypeptide or an interleukin 36γ (IL-36-gamma) polypeptide), and an immune response co-stimulatory signal polypeptide (e.g., an OX40L polypeptide).

公开(公告)号：US20210038529A1

公开(公告)日：2021-02-11

申请号：US17071685

申请日：2020-10-15

Applicant: ModernaTX, Inc.

Inventor： Joshua FREDERICK ,  Ailin BAI ,  Vladimir PRESNYAK ,  Stephen G. HOGE ,  Kerry BENENATO ,  Iain MCFADYEN ,  Ellalahewage Sathyajith KUMARASINGHE ,  Susannah HEWITT

IPC: A61K9/51 ,  A61K48/00 ,  A61K38/17 ,  A61K38/20 ,  A61K9/00 ,  A61K39/39 ,  A61K45/06 ,  A61K9/127 ,  C07K14/54 ,  C07K14/545 ,  C07K14/705 ,  A61P35/00 ,  A61K39/395

Abstract: The disclosure relates to compositions and methods for the preparation, manufacture and therapeutic use of combinations of immunomodulatory polynucleotides (e.g., mRNAs) encoding an immune response primer polypeptide (e.g., an interleukin 23 (IL-23) polypeptide or an interleukin 36γ (IL-36-gamma) polypeptide), and an immune response co-stimulatory signal polypeptide (e.g., an OX40L polypeptide).