公开(公告)号：US20080300196A1

公开(公告)日：2008-12-04

申请号：US11866542

申请日：2007-10-03

申请人： Ashwani Kumar Verma ,  Sanjay Malhotra ,  Sankaranarayanan Dharmarajan ,  Rajkumar Shirumalla ,  Abhijit Ray

发明人： Ashwani Kumar Verma ,  Sanjay Malhotra ,  Sankaranarayanan Dharmarajan ,  Rajkumar Shirumalla ,  Abhijit Ray

IPC分类号： A61K31/7052 ,  C07H17/02 ,  A61K31/70 ,  A61P9/00 ,  A61P37/00 ,  A61P35/00 ,  A61P29/00 ,  C07H15/00

CPC分类号： C07H3/02 ,  C07H9/04 ,  C07H15/00

摘要： The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disclosed herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory, cancer, cardiovascular and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type-I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, pruritis or allergic rhinitis. Pharmacological compositions containing compounds disclosed herein and the methods of treating diseases such as bronchial asthma, rheumatoid arthritis, type-I diabetes, multiple sclerosis, cancer, cardiovascular diseases, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, pruritis or allergic rhinitis and other inflammatory and/or autoimmune disorders, using the compounds are also provided.

摘要翻译： 本发明涉及作为抗炎剂的单糖衍生物。 本文公开的化合物可用于抑制和预防炎症和相关病理，包括炎症，癌症，心血管和自身免疫性疾病如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化，同种异体移植排斥，牛皮癣，炎性肠病， 溃疡性结肠炎，痤疮，动脉粥样硬化，瘙痒或过敏性鼻炎。 包含本文公开的化合物的药理学组合物和治疗诸如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化症，癌症，心血管疾病，同种异体移植排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，瘙痒症 或使用该化合物的过敏性鼻炎和其它炎症和/或自身免疫性疾病。