公开(公告)号：US09169251B2

公开(公告)日：2015-10-27

申请号：US14316503

申请日：2014-06-26

Applicant: Novartis AG

Inventor： Kamlesh Jagdis Bala ,  Catherine Leblanc ,  David Andrew Sandham ,  Katharine Louise Turner ,  Simon James Watson ,  Lyndon Nigel Brown ,  Brian Cox

IPC: A61K31/437 ,  A61K45/06 ,  C07D471/04

CPC classification number: C07D471/04 ,  A61K31/437 ,  A61K45/06

Abstract: There are provided according to the invention compounds of formula (I) in free or salt form, wherein R1, R2, R3, R4, R5, R6, Q, W, X, m, n and p are as described in the specification, process for preparing them, and their use as pharmaceuticals.

Abstract translation: 根据本发明，提供游离或盐形式的式（I）化合物，其中R 1，R 2，R 3，R 4，R 5，R 6，Q，W，X，m，n和p如说明书中所述， 制备它们的过程，以及它们作为药物的用途。

公开(公告)号：US20140336166A1

公开(公告)日：2014-11-13

申请号：US14353950

申请日：2012-10-26

Applicant: NOVARTIS AG

Inventor： Emmanuelle Briard ,  Pascal Furet ,  Andreas Lerchner ,  Peter Meier ,  Branko Radetich ,  David Andrew Sandham ,  Yanyi Zhu

IPC: C07D473/16 ,  C07D491/048 ,  C07D491/107 ,  A61K31/5377 ,  A61K31/553

CPC classification number: C07D473/16 ,  A61K31/5377 ,  A61K31/553 ,  C07D487/04 ,  C07D491/048 ,  C07D491/107 ,  C07D519/00

Abstract: The invention relates to PI3K inhibitors of the formula (I) • in which all of the variables are as defined in the specification, to their preparation, to their medical use, in particular to their use in the treatment of cancer and neurodegenerative disorders, and to medicaments comprising them.

Abstract translation: 本发明涉及式（I）的PI3K抑制剂，其中所有变量如说明书中所定义，其制备，其医疗用途，特别是其在治疗癌症和神经变性疾病中的用途，以及 包括它们的药物。