专利检索 ap:("Nalin Subasinghe" OR "Ehab Khalil" OR "Kristi Leonard" OR "Farah Ali" OR "Heather Hufnagel" OR "Jeremy Travins" OR "Shelley Ballentine" OR "Kenneth Wilson" OR "Maxwell Cummings" OR "Wenxi Pan" OR "Joan Gushue" OR "Sanath Meegalla" OR "Mark Wall" OR "Jinsheng Chen") AND inv:"Maxwell Cummings" 第 2 页

11.

发明申请
Protease inhibitors 失效

公开(公告)号：US20060194787A1

公开(公告)日：2006-08-31

申请号：US11410558

申请日：2006-04-25

申请人： Maxwell Cummings , Robert Marquis , Yu Ru , Scott Thompson , Daniel Veber , Dennis Yamashita

发明人： Maxwell Cummings , Robert Marquis , Yu Ru , Scott Thompson , Daniel Veber , Dennis Yamashita

IPC分类号： A61K31/55 , C07D413/02 , C07D403/02

CPC分类号： C07C271/12 , C07C271/14 , C07D223/04 , C07D223/08 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D491/04 , C07D495/04

摘要： The present invention provides C1-6alkyl-4-amino-azepan-3-one protease inhibitors and pharmaceutically acceptable salts, hydrates and solvates thereof which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, novel intermediates of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget's disease; hypercalcemia of malignancy; and metabolic bone disease; and parasitic diseases, including malaria, by administering to a patient in need thereof one or more compounds of the present invention.