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公开(公告)号:US20090270370A1
公开(公告)日:2009-10-29
申请号:US12496866
申请日:2009-07-02
申请人: Nicholas I. Carruthers , Wenying Chai , Xiaohu Deng , Curt A. Dvorak , Annette K. Kwok , Jimmy T. Liang , Neelakandha Mani , Dale A. Rudolph , Victoria D. Wong
发明人: Nicholas I. Carruthers , Wenying Chai , Xiaohu Deng , Curt A. Dvorak , Annette K. Kwok , Jimmy T. Liang , Neelakandha Mani , Dale A. Rudolph , Victoria D. Wong
IPC分类号: A61K31/437 , C07D471/04 , C07D487/04 , A61K31/55 , A61K31/4162
CPC分类号: C07D487/04
摘要: Certain fused pyrrole- and pyrazole-containing heterocyclic compounds are serotonin modulators useful in the treatment of serotonin-mediated diseases.
摘要翻译: 某些稠合的含吡咯和吡唑的杂环化合物是可用于治疗5-羟色胺介导的疾病的血清素调节剂。
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公开(公告)号:US07402680B2
公开(公告)日:2008-07-22
申请号:US10941664
申请日:2004-09-15
申请人: Nicholas I. Carruthers , Wenying Chai , Xiaohu Deng , Curt A. Dvorak , Annette K. Kwok , Jimmy T. Liang , Neelakandha Mani , Dale A. Rudolph , Victoria D. Wong
发明人: Nicholas I. Carruthers , Wenying Chai , Xiaohu Deng , Curt A. Dvorak , Annette K. Kwok , Jimmy T. Liang , Neelakandha Mani , Dale A. Rudolph , Victoria D. Wong
IPC分类号: C07D471/02
CPC分类号: C07D487/04
摘要: Certain fused pyrrole- and pyrazole-containing heterocyclic compounds are serotonin modulators useful in the treatment of serotonin-mediated diseases.
摘要翻译: 某些稠合的含吡咯和吡唑的杂环化合物是可用于治疗5-羟色胺介导的疾病的血清素调节剂。
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公开(公告)号:US07897771B2
公开(公告)日:2011-03-01
申请号:US12496866
申请日:2009-07-02
申请人: Nicholas I. Carruthers , Wenying Chai , Xiaohu Deng , Curt A. Dvorak , Annette K. Kwok , Jimmy T. Liang , Neelakandha Mani , Dale A. Rudolph , Victoria D. Wong
发明人: Nicholas I. Carruthers , Wenying Chai , Xiaohu Deng , Curt A. Dvorak , Annette K. Kwok , Jimmy T. Liang , Neelakandha Mani , Dale A. Rudolph , Victoria D. Wong
IPC分类号: C07D417/02 , A01N43/42
CPC分类号: C07D487/04
摘要: Certain fused pyrrole- and pyrazole-containing heterocyclic compounds are serotonin modulators useful in the treatment of serotonin-mediated diseases.
摘要翻译: 某些稠合的含吡咯和吡唑的杂环化合物是可用于治疗5-羟色胺介导的疾病的血清素调节剂。
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公开(公告)号:US07071191B2
公开(公告)日:2006-07-04
申请号:US09922619
申请日:2001-08-06
IPC分类号: A61K31/5375 , C07D413/12
CPC分类号: C07D207/325 , A61K31/4402 , A61K31/4465 , A61K45/06 , C07C217/22 , C07C323/25 , C07C335/32 , C07D207/335 , C07D211/22 , C07D211/46 , C07D211/58 , C07D213/36 , C07D213/74 , C07D215/06 , C07D231/12 , C07D233/42 , C07D233/54 , C07D233/56 , C07D233/84 , C07D233/88 , C07D235/06 , C07D235/26 , C07D239/34 , C07D249/08 , C07D257/04 , C07D277/36 , C07D295/088 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/205 , C07D307/52 , C07D317/28 , C07D333/20 , C07D401/12 , C07D401/14 , C07D471/08 , A61K2300/00
摘要: Substituted non-imidazole aryloxypiperidine compounds, compositions containing them, and methods of making and using them to treat or prevent histamine-mediated conditions.
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公开(公告)号:US20080306085A1
公开(公告)日:2008-12-11
申请号:US12194653
申请日:2008-08-20
申请人: Richard Apodaca , Nicholas I. Carruthers , Curt A. Dvorak , Dale A. Rudolph , Chandravadan R. Shah , Wei Xiao
发明人: Richard Apodaca , Nicholas I. Carruthers , Curt A. Dvorak , Dale A. Rudolph , Chandravadan R. Shah , Wei Xiao
IPC分类号: A61K31/445 , A61P25/00 , A61K31/496 , A61K31/47 , A61K31/444 , A61P3/00
CPC分类号: C07D207/325 , A61K31/4402 , A61K31/4465 , A61K45/06 , C07C217/22 , C07C323/25 , C07C335/32 , C07D207/335 , C07D211/22 , C07D211/46 , C07D211/58 , C07D213/36 , C07D213/74 , C07D215/06 , C07D231/12 , C07D233/42 , C07D233/54 , C07D233/56 , C07D233/84 , C07D233/88 , C07D235/06 , C07D235/26 , C07D239/34 , C07D249/08 , C07D257/04 , C07D277/36 , C07D295/088 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/205 , C07D307/52 , C07D317/28 , C07D333/20 , C07D401/04 , C07D401/12 , C07D401/14 , C07D471/08 , A61K2300/00
摘要: Substituted aryloxyalkylamines of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
摘要翻译: 式(I)的取代的芳氧基烷基胺,含有它们的组合物,以及制备和使用它们来治疗组胺介导的病症的方法。
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公开(公告)号:US07241778B2
公开(公告)日:2007-07-10
申请号:US11138631
申请日:2005-05-26
IPC分类号: A61K31/445 , C07D211/06
CPC分类号: C07D207/325 , A61K31/4402 , A61K31/4465 , A61K45/06 , C07C217/22 , C07C323/25 , C07C335/32 , C07D207/335 , C07D211/22 , C07D211/46 , C07D211/58 , C07D213/36 , C07D213/74 , C07D215/06 , C07D231/12 , C07D233/42 , C07D233/54 , C07D233/56 , C07D233/84 , C07D233/88 , C07D235/06 , C07D235/26 , C07D239/34 , C07D249/08 , C07D257/04 , C07D277/36 , C07D295/088 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/205 , C07D307/52 , C07D317/28 , C07D333/20 , C07D401/12 , C07D401/14 , C07D471/08 , A61K2300/00
摘要: Substituted non-imidazole aryloxypiperidine compounds, compositions containing them, and methods of making and using them to treat or prevent histamine-mediated conditions.
摘要翻译: 取代的非咪唑芳氧基哌啶化合物,含有它们的组合物,以及制备和使用它们来治疗或预防组胺介导的病症的方法。
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公开(公告)号:US20100004241A1
公开(公告)日:2010-01-07
申请号:US12541447
申请日:2009-08-14
申请人: Richard Apodaca , Nicholas I. Carruthers , Curt A. Dvorak , Dale A. Rudolph , Chandravadan R. Shah , Wei Xiao
发明人: Richard Apodaca , Nicholas I. Carruthers , Curt A. Dvorak , Dale A. Rudolph , Chandravadan R. Shah , Wei Xiao
IPC分类号: A61K31/5377 , A61K31/445 , A61P25/28 , A61P25/18 , A61P25/24 , A61K31/496 , A61K31/4523 , A61K31/4725 , A61K31/4545 , A61K31/4709 , A61K31/506 , A61K31/4439 , A61K31/438 , A61K31/439
CPC分类号: C07D207/325 , A61K31/4402 , A61K31/4465 , A61K45/06 , C07C217/22 , C07C323/25 , C07C335/32 , C07D207/335 , C07D211/22 , C07D211/46 , C07D211/58 , C07D213/36 , C07D213/74 , C07D215/06 , C07D231/12 , C07D233/42 , C07D233/54 , C07D233/56 , C07D233/84 , C07D233/88 , C07D235/06 , C07D235/26 , C07D239/34 , C07D249/08 , C07D257/04 , C07D277/36 , C07D295/088 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/205 , C07D307/52 , C07D317/28 , C07D333/20 , C07D401/04 , C07D401/12 , C07D401/14 , C07D471/08 , A61K2300/00
摘要: Substituted aryloxyalkylamines of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
摘要翻译: 式(I)的取代的芳氧基烷基胺,含有它们的组合物,以及制备和使用它们来治疗组胺介导的病症的方法。
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公开(公告)号:US07186732B2
公开(公告)日:2007-03-06
申请号:US09922631
申请日:2001-08-06
申请人: Richard Apodaca , Nicholas I. Carruthers , Curt A. Dvorak , Dale A. Rudolph , Chandravadan R. Shah , Wei Xiao
发明人: Richard Apodaca , Nicholas I. Carruthers , Curt A. Dvorak , Dale A. Rudolph , Chandravadan R. Shah , Wei Xiao
IPC分类号: A61K31/445 , C07D211/08
CPC分类号: C07D207/325 , A61K31/4402 , A61K31/4465 , A61K45/06 , C07C217/22 , C07C323/25 , C07C335/32 , C07D207/335 , C07D211/22 , C07D211/46 , C07D211/58 , C07D213/36 , C07D213/74 , C07D215/06 , C07D231/12 , C07D233/42 , C07D233/54 , C07D233/56 , C07D233/84 , C07D233/88 , C07D235/06 , C07D235/26 , C07D239/34 , C07D249/08 , C07D257/04 , C07D277/36 , C07D295/088 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/205 , C07D307/52 , C07D317/28 , C07D333/20 , C07D401/04 , C07D401/12 , C07D401/14 , C07D471/08 , A61K2300/00
摘要: Substituted aryloxyalkylamines of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
摘要翻译: 式(I)的取代的芳氧基烷基胺,含有它们的组合物,以及制备和使用它们来治疗组胺介导的病症的方法。
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公开(公告)号:US07429586B2
公开(公告)日:2008-09-30
申请号:US11453422
申请日:2006-06-15
申请人: Richard Apodaca , Nicholas I. Carruthers , Curt A. Dvorak , Dale A. Rudolph , Chandravadan R. Shah , Wei Xiao
发明人: Richard Apodaca , Nicholas I. Carruthers , Curt A. Dvorak , Dale A. Rudolph , Chandravadan R. Shah , Wei Xiao
IPC分类号: A61K31/435 , C07D217/00
CPC分类号: C07D207/325 , A61K31/4402 , A61K31/4465 , A61K45/06 , C07C217/22 , C07C323/25 , C07C335/32 , C07D207/335 , C07D211/22 , C07D211/46 , C07D211/58 , C07D213/36 , C07D213/74 , C07D215/06 , C07D231/12 , C07D233/42 , C07D233/54 , C07D233/56 , C07D233/84 , C07D233/88 , C07D235/06 , C07D235/26 , C07D239/34 , C07D249/08 , C07D257/04 , C07D277/36 , C07D295/088 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/205 , C07D307/52 , C07D317/28 , C07D333/20 , C07D401/04 , C07D401/12 , C07D401/14 , C07D471/08 , A61K2300/00
摘要: Substituted aryloxyalkylamines of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
摘要翻译: 式(I)的取代的芳氧基烷基胺,含有它们的组合物,以及制备和使用它们来治疗组胺介导的病症的方法。
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20.SUBSTITUTED PYRROLIDINE AMIDES AS MODULATORS OF THE HISTAMINE H3 RECEPTOR 有权
标题翻译: 作为组胺H3受体的调节剂的替代吡咯烷公开(公告)号:US20090291903A1
公开(公告)日:2009-11-26
申请号:US12468632
申请日:2009-05-19
申请人: Nicholas I. Carruthers , Michael A. Letavic , Kiev S. Ly , Neelakandha S. Mani , Daniel J. Pippel , Chandravadan R. Shah , Akinola Soyode-Johnson , Emily M. Stocking , Lana Young
发明人: Nicholas I. Carruthers , Michael A. Letavic , Kiev S. Ly , Neelakandha S. Mani , Daniel J. Pippel , Chandravadan R. Shah , Akinola Soyode-Johnson , Emily M. Stocking , Lana Young
IPC分类号: A61K38/05 , C07D403/06 , A61K31/551
CPC分类号: C07D403/06 , C07D401/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要: Certain substituted pyrrolidine amide compounds are histamine H3 receptor modulators useful in the treatment of histamine H3 receptor-mediated diseases.
摘要翻译: 某些取代的吡咯烷酰胺化合物是可用于治疗组胺H3受体介导的疾病的组胺H3受体调节剂。
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