专利检索 ap:("Novartis AG") AND inv:"Julien Papillon" 第 2 页

11.

发明授权
Protein kinase C inhibitors and methods of their use 有权

公开(公告)号：US09845309B2

公开(公告)日：2017-12-19

申请号：US15237880

申请日：2016-08-16

申请人： NOVARTIS AG

发明人： Michael Joseph Luzzio , Julien Papillon , Michael Scott Visser

IPC分类号： C07D401/14 , A61K31/497 , C07D413/14

CPC分类号： C07D401/14 , A61K31/497 , C07D413/14

摘要： PKC inhibitors are disclosed. The PKC inhibitors are useful for treating PKC associated diseases, including certain cancers. The PKC inhibitors have improved efficacy at lower dosage amounts to achieve tumor regression, improved potency, PK profile, absorption, gastrointestinal tolerance and kinase selectivity.