公开(公告)号：US08912128B2

公开(公告)日：2014-12-16

申请号：US13740367

申请日：2013-01-14

Applicant: Postech Academy-Industry Foundation

Inventor： Hyung Joon Cha ,  Chang Sup Kim ,  Jeong Hyun Seo ,  Hwahui Shin

IPC: G01N33/569 ,  C12Q1/10 ,  C40B30/04 ,  C40B40/12

CPC classification number: G01N33/56911 ,  G01N2333/28

Abstract: The present invention related to a saccharide-based cholera toxin detection sensor for detection of Vibrio cholerae and its use. More specifically, the present invention relates to a carbohydrate chip for detection of Vibrio cholerae, a method for detecting Vibrio cholerae using the same, and a method for preparing the same, where the carbohydrate chip comprises GM1 pentasaccharide, GM2 tetrasaccharide, asialo GM1 tetrasaccharide, GM3 trisaccharide, galactose-β 1,3-N-acetylgalactosamine, lactose, and sialic acid that are immobilized on the surface of a solid substrate.

Abstract translation: 本发明涉及用于检测霍乱弧菌的糖类霍乱毒素检测传感器及其用途。 更具体地说，本发明涉及用于检测霍乱弧菌的碳水化合物芯片，使用其的霍乱弧菌检测方法及其制备方法，其中碳水化合物芯片包含GM1五糖，GM2四糖，脱ial GM1四糖， GM3三糖，半乳糖 - 固定在固体基质表面上的1,3-N-乙酰半乳糖胺，乳糖和唾液酸。

公开(公告)号：US08765682B2

公开(公告)日：2014-07-01

申请号：US13917766

申请日：2013-06-14

Applicant: Postech Academy-Industry Foundation

Inventor： Hyung Joon Cha ,  Byeongseon Yang ,  Yoo Seong Choi ,  Hyungdon Yun

IPC: A61K38/16 ,  C07H21/04 ,  C09J189/00 ,  C12N5/10 ,  C12P21/06 ,  A61P17/02 ,  C07K14/435 ,  C12N15/63

CPC classification number: A61K38/16 ,  C07K14/43504

Abstract: The present invention relates to recombinant mussel adhesive protein wherein a DOPA residue is in vivo incorporated instead of a tyrosine residue, and a method for producing the same. More specifically, the present invention relates to recombinant mussel adhesive protein wherein a DOPA residue is incorporated instead of a tyrosine residue, and a method for producing the same, and a transformant for producing the recombinant mussel adhesive protein.

公开(公告)号：US20210139608A1

公开(公告)日：2021-05-13

申请号：US17065368

申请日：2020-10-07

Applicant: Postech Academy-Industry Foundation

Inventor： Kye II Joo ,  Hyung Joon Cha ,  Yeon Su Jeong

IPC: C07K16/44 ,  A61K45/00

Abstract: Disclosed are a bio-responsive adhesive antibody delivery platform for immunotherapy, use thereof, and a preparation method thereof. The bio-responsive adhesive antibody delivery platform for immunotherapy according to the present disclosure may enhance a retention time of the antibody at a target site via adhesiveness of the delivery platform and may selectively release the antibody in response to specific enzymes to efficiently deliver the antibody.

公开(公告)号：US20200299556A1

公开(公告)日：2020-09-24

申请号：US16649224

申请日：2018-07-10

Applicant: POSCO ,  POSTECH ACADEMY-INDUSTRY FOUNDATION ,  NATURE GLUETECH CO., LTD.

Inventor： Hyung Joon Cha ,  Hyo Jeong Kim ,  Bong-Hyuk Choi

IPC: C09J189/00

Abstract: The present invention relates to: a coacervate formed from a catechol-substituted anionic polymer; an adhesive comprising same; and a method for producing same. More specifically, the present invention relates to: a coacervate formed by mixing a catechol derivative of a mussel adhesive protein and a catechol-substituted anionic polymer; an adhesive comprising the coacervate; and a method for producing a coacervate, wherein the method comprises a step of obtaining a catechol-substituted anionic polymer through catechol substitution of an anionic polymer, and a step of mixing the catechol-substituted anionic polymer and a catechol derivative of a mussel adhesive protein.

公开(公告)号：US20200231637A1

公开(公告)日：2020-07-23

申请号：US16631133

申请日：2018-07-13

Applicant: POSCO ,  POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Hyung Joon Cha ,  Yun Kee Jo ,  Yeonsu Jeong

IPC: C07K14/435 ,  C07K7/08 ,  C07K7/06 ,  A61K9/51 ,  A61K47/54 ,  A61P31/04

Abstract: The present invention relates to an antimicrobial adhesive protein, an antimicrobial nanoparticle, an antimicrobial composition comprising the same nanoparticle, and a preparation method for the same composition and, more particularly, to an antimicrobial adhesive protein in which an antibiotic peptide is linked to a mussel adhesive protein, a mussel adhesive protein derivative in which a tyrosine residue within the antimicrobial adhesive protein is modified with a catechol derivative, an antimicrobial nanoparticle including a metal capable of forming a coordinate bond with a derivative of the mussel adhesive protein and having intrinsic antimicrobial activity, an antimicrobial composition comprising the same nanoparticle, and a preparation method for the same composition.