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24 条记录 (耗时 0.023 秒)

    Pyrido�3,4-e!-as-triazines
    11.
    发明授权
    Pyrido�3,4-e!-as-triazines 失效
    吡啶并[3,4-e] -as-三嗪

    公开(公告)号：US4424351A

    公开(公告)日：1984-01-03

    申请号：US123807

    申请日：1980-02-22

    申请人： Pal Benko ,  Gyo/ rgyi nee Lax Kovanyi ,  Judit nee Gergely Timar ,  Maria nee Lakatos Sigmond ,  Lujza Petocz ,  Peter Go/ ro/ g ,  Ibolya Kosoczky ,  Eniko nee Kiszelly Szirt ,  Hristone Toncsev

    发明人： Pal Benko ,  Gyo/ rgyi nee Lax Kovanyi ,  Judit nee Gergely Timar ,  Maria nee Lakatos Sigmond ,  Lujza Petocz ,  Peter Go/ ro/ g ,  Ibolya Kosoczky ,  Eniko nee Kiszelly Szirt ,  Hristone Toncsev

    IPC分类号： A61K31/53 ,  A61P25/04 ,  A61P29/00 ,  C07D471/04

    CPC分类号： C07D471/04

    摘要： Acylated pyrido �3,4-e!-as-triazines of the formula (I), ##STR1## wherein R.sub.1 stands for alkyl, alkoxy, haloalkyl, furyl, pyridyl, phenyl, phenyl-(C.sub.1-4 alkyl) or phyenyl-(C.sub.2-4 alkenyl) optionally substituted. R.sub.2 stands for hydrogen or a group of the formula R.sub.1 --CO--, R.sub.3 stands for hydrogen, a phenyl group or a naphthy6l group optionally substituted, or a phenyl-(C.sub.1-4 alkyl) group, pyridyl group or a C.sub.1-20 alkyl group, and R.sub.4 stands for hydrogen or a group of the formula R.sub.1 --CO--, and R.sub.5 forms together with R.sub.2 or R.sub.4 a valence bond, wherein R.sub.2 or R.sub.4 taking part in forming said valence bond may not have the above meaning, and pharmaceutically acceptable acid addition salts thereof, which are prepared by reacting a pyrido �3,4-e!-as-triazine of the formula (II) or an acid addition salt thereof ##STR2## R.sub.6 stands for hydrogen, and R.sub.5 forms together with R.sub. and R.sub.4 a valence bond, with an acylating agent of the formula (III). R.sub.1 --CO--X (III) The compounds exert favourable effects on the central nervous system, and can be applied primarily as analgesic and antiphlogistic agents.

    摘要翻译： 式（I）的酰化吡啶并[3,4-e] -as-三嗪，其中R1代表烷基，烷氧基，卤代烷基，呋喃基，吡啶基，苯基，苯基 - （C1-4烷基）或 （烯基）（C 2-4烯基）任意取代。 R2代表氢或式R1-CO-的基团，R3代表氢，苯基或任选取代的萘基，或苯基 - （C 1-4烷基）基，吡啶基或C 1-20烷基， R4代表氢或式R1-CO-基团，R5与R2或R4一起形成价键，其中参与形成所述价键的R2或R4可能不具有上述含义，并且其药学上可接受的酸 通过使式（II）的吡啶并[3,4-e]-α-三嗪或其酸加成盐反应制备的加成盐，其中R6代表氢，R5与 兰德R4是价键，具有式（III）的酰化剂。 R1-CO-X（III）该化合物对中枢神经系统具有有利的作用，可主要用作镇痛药和消炎药。

    Carbazic acid derivatives, process for their preparation and compositions containing the same
    13.
    发明授权
    Carbazic acid derivatives, process for their preparation and compositions containing the same 失效
    咔唑酸衍生物，其制备方法和含有它们的组合物

    公开(公告)号：US4618623A

    公开(公告)日：1986-10-21

    申请号：US737388

    申请日：1985-05-23

    申请人： Zoltan Budai ,  Pal Benko ,  Ildiko Ratz nee Simonek ,  Eva Rakoczy nee Pinter ,  Karoly Magyar ,  Jozsef Kelemen ,  Attila Mandi

    发明人： Zoltan Budai ,  Pal Benko ,  Ildiko Ratz nee Simonek ,  Eva Rakoczy nee Pinter ,  Karoly Magyar ,  Jozsef Kelemen ,  Attila Mandi

    IPC分类号： C07C281/02 ,  A23K1/16 ,  A23K1/18 ,  C07C67/00 ,  C07C239/00 ,  C07C281/04 ,  A61K31/27

    CPC分类号： A23K50/30 ,  A23K20/105 ,  A23K20/111

    摘要： The invention relates to new carbazic acid derivatives, a process for the preparation thereof and compositions--particularly feed additives and animal feeds--containing the same. The new compounds according to the invention correspond to the formula (I)R.sup.1 .dbd.N--NH--COOR.sup.3 (I)wherein R.sup.1 stands for a C.sub.7-12 cycloalkylidene group, an indanylidene group or a group of the formula (IX) ##STR1## wherein A represents a phenyl group optionally carrying one or more identical or different substituents selected from the group consisting of halo, nitro, hydroxy, C.sub.1-4 alkoxy, C.sub.1-4 alkyl, amino or C.sub.1-4 alkoxycarbonylhydrazino; phenyl-(C.sub.1-4 alkyl), C.sub.1-16 alkyl, C.sub.3-7 cycloalkyl or indolyl, or a C.sub.3 -C.sub.6 cycloalkyl group substituted by a C.sub.3 -C.sub.6 cycloalkyl group; R.sup.2 denotes a hydrogen atom, a C.sub.1-16 alkyl or a C.sub.3-7 cycloalkyl group; and R.sup.3 represents a C.sub.1-4 alkyl group.

    摘要翻译： 本发明涉及新的卡巴酸衍生物，其制备方法和组合物 - 特别是饲料添加剂和含有它们的动物饲料。 根据本发明的新化合物对应于式（I）R 1 = N-NH-COOR 3（I）其中R 1表示C 7-12亚环烷基，亚茚基或式（Ⅸ）的基团） （IX）其中A表示任选携带一个或多个相同或不同的取代基的苯基，所述取代基选自卤素，硝基，羟基，C 1-4烷氧基，C 1-4烷基，氨基或C 1-4烷氧基羰基肼; 苯基 - （C 1-4烷基），C 1-16烷基，C 3-7环烷基或吲哚基，或被C 3 -C 6环烷基取代的C 3 -C 6环烷基; R2表示氢原子，C1-16烷基或C3-7环烷基; 并且R 3表示C 1-4烷基。

    Quinoxaline-2-yl ethenyl ketones
    14.
    发明授权
    Quinoxaline-2-yl ethenyl ketones 失效
    喹喔啉-2-基乙烯基酮

    公开(公告)号：US4373101A

    公开(公告)日：1983-02-08

    申请号：US269721

    申请日：1981-06-02

    申请人： Pal Benko ,  Daniel Bozsing ,  Janos Gundel ,  Karoly Magyar

    发明人： Pal Benko ,  Daniel Bozsing ,  Janos Gundel ,  Karoly Magyar

    IPC分类号： A23K1/16 ,  A23K1/17 ,  A61K31/495 ,  A61K31/498 ,  A61P3/00 ,  A61P21/06 ,  A61P31/04 ,  C07D241/52 ,  C07D401/06 ,  C07D405/06 ,  C09B55/00

    CPC分类号： C07D241/52 ,  A23K20/116 ,  A23K20/195

    摘要： The invention relates to novel quinoxaline-2-yl ethenyl ketones, their preparation and compositions containing them.The novel quinoxaline-2-yl ethenyl ketones of the general formula I ##STR1## wherein R.sub.1 represents an aryl group or a heterocyclic group comprising one or more nitrogen and/or oxygen and/or sulfur atoms wherein both the aryl and heterocyclic groups are optionally substituted by one or more identical or different substituents,R.sub.2 stands for a hydrogen atom or a C.sub.1-4 alkyl group, are prepared by reacting an acetylquinoxaline derivative of the general formula II ##STR2## wherein R.sub.2 is as stated above, with an aldehyde of the general formula IIIR.sub.1 --CHO (III) wherein R.sub.1 is as stated above.The novel compounds of the general formula I possess valuable antibacterial effect and promote the growth of animals. Thus, the novel compounds can be incorporated in animal feeds.

    摘要翻译： 本发明涉及新型喹喔啉-2-基乙烯基酮，其制备方法和含有它们的组合物。 通式Ⅰ（I）的新型喹喔啉-2-基乙烯基酮其中R 1表示芳基或包含一个或多个氮和/或氧和/或硫原子的杂环基，其中芳基和杂环 基团任选地被一个或多个相同或不同的取代基取代，R2代表氢原子或C1-4烷基，是通过使通式II的乙酰基喹喔啉衍生物（II）（其中R 2如所述）而制备的 与通式III的R 1 -CH（III）的醛反应，其中R 1如上所述。 通式Ⅰ的新型化合物具有有价值的抗菌作用，促进动物的生长。 因此，新化合物可以并入动物饲料中。

    Carbazates
    17.
    发明授权
    Carbazates 失效
    Car子

    公开(公告)号：US4824670A

    公开(公告)日：1989-04-25

    申请号：US808352

    申请日：1985-12-11

    申请人： Ildiko Ratz nee Simonek ,  Pal Benko ,  Edit Bernenyi nee Poldermann ,  Karoly Magyar

    发明人： Ildiko Ratz nee Simonek ,  Pal Benko ,  Edit Bernenyi nee Poldermann ,  Karoly Magyar

    IPC分类号： C07C281/00 ,  A23K1/16 ,  A23K1/18 ,  A61K31/27 ,  A61P3/00 ,  C07C67/00 ,  C07C239/00 ,  C07C281/02 ,  C07D231/56 ,  C07D307/71 ,  A23L1/30

    CPC分类号： C07D231/56 ,  A23K20/105 ,  A23K20/111 ,  A23K20/116 ,  A23K50/30 ,  C07D307/71

    摘要： The present invention relates to new carbazates of the general formula (I), ##STR1## wherein A is C.sub.3-10 alkyl, C.sub.3-10 alkenyl, C.sub.2-10 haloalkyl, trifluoromethyl, phenyl-C.sub.1-3 alkyl, phenyl-C.sub.2-3 -alkenyl, naphthyl-C.sub.1-3 alkyl; phenyl optionally substituted by one or more identical or different substituent(s) selected from C.sub.1-4 alkyl, halogen, C.sub.1-4 alkoxy and hydroxy; C.sub.3-7 cycloalkyl-C.sub.1-3 alkyl; optionally nitro-substituted furyl; diphenyl-hydroxy-methyl or indazolyl optionally substituted by one or more C.sub.1-4 alkoxy group(s) andR represents C.sub.1-4 alkyl,with the proviso that if R stands for ethyl, A is other than tertiary butyl, and acid addition salts thereof, a process for the preparation thereof and feed-additives comprising the same.The compounds of the general formula (I) may be used in animal husbandry due to their weight-gain increasing and fodder utilization improving effect.

    摘要翻译： 本发明涉及通式（I）的新的肼基甲酸酯，其中A为C 3-10烷基，C 3-10烯基，C 2-10卤代烷基，三氟甲基，苯基-C 1-3烷基，苯基-C 2 -3-烯基，萘基-C 1-3烷基; 任选被一个或多个相同或不同的选自C 1-4烷基，卤素，C 1-4烷氧基和羟基的取代基取代的苯基; C 3-7环烷基-C 1-3烷基; 任选硝基取代的呋喃基; 任选被一个或多个C 1-4烷氧基取代的二苯基 - 羟基 - 甲基或吲唑基，R表示C 1-4烷基，条件是如果R代表乙基，则A不是叔丁基，而酸加成盐 其制备方法和包含其的饲料添加剂。 通式（I）的化合物可以用于畜牧业，因为它们的增重和饲料利用率的改善效果。

    Carbazates
    19.
    发明授权
    Carbazates 失效
    Car子

    公开(公告)号：US4883907A

    公开(公告)日：1989-11-28

    申请号：US179595

    申请日：1988-04-11

    申请人： Ildiko Ratz nee Simonek ,  Pal Benko ,  Edit Berenyi nee Foldermann ,  Karoly Magyar

    发明人： Ildiko Ratz nee Simonek ,  Pal Benko ,  Edit Berenyi nee Foldermann ,  Karoly Magyar

    IPC分类号： A23K1/16 ,  A23K1/18 ,  C07D231/56 ,  C07D307/71

    CPC分类号： C07D231/56 ,  A23K20/105 ,  A23K20/111 ,  A23K20/116 ,  A23K50/30 ,  C07D307/71

    摘要： The present invention relates to new carbazates of the formula (I) ##STR1## wherein A is C.sub.3 to C.sub.10 alkenyl, C.sub.2 to C.sub.10 haloalkyl, trifluoromethyl, phenyl-C.sub.1 to C.sub.3 alkyl, phenyl-C.sub.2 to C.sub.3 alkenyl, naphthyl-C.sub.1 to C.sub.3 alkyl, C.sub.3 to C.sub.7 cycloalkyl-C.sub.1 to C.sub.3 alkyl, furyl which can be nitro-substituted, diphenyl-hydroxymethyl or indazolyl which can be substituted by one or more C.sub.1 to C.sub.4 alkoxy groups; andR is C.sub.1 to C.sub.4 alkyl,and acid addition salts thereof, a process for the preparation thereof and feed additives comprising the same.The compounds of formula (I) may be used in animal husbandry due to their weight-gain increasing and fodder utilization improving effect.

    摘要翻译： 本发明涉及式（I）的新的肼基甲酸酯其中A为C 3至C 10烯基，C 2至C 10卤代烷基，三氟甲基，苯基-C 1至C 3烷基，苯基-C 2至C 3烯基， C 1 -C 3烷基，C 3至C 7环烷基-C 1至C 3烷基，可被硝基取代的呋喃基，可被一个或多个C 1至C 4烷氧基取代的二苯基 - 羟甲基或吲唑基; 和R是C1-C4烷基，及其酸加成盐，其制备方法和含有它们的饲料添加剂。 由于其增重和饲料利用率的改善效果，式（I）化合物可用于畜牧业。