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公开(公告)号:US20090170904A1
公开(公告)日:2009-07-02
申请号:US12315779
申请日:2008-12-05
申请人: Mina E. Aikawa , Payman Amiri , Jeffrey H. Dove , Barry Haskell Levine , Christopher McBride , Teresa E. Pick , Daniel J. Poon , Savithri Ramurthy , Paul A. Renhowe , Cynthia Shafer , Darrin Stuart , Sharadha Subramanian
发明人: Mina E. Aikawa , Payman Amiri , Jeffrey H. Dove , Barry Haskell Levine , Christopher McBride , Teresa E. Pick , Daniel J. Poon , Savithri Ramurthy , Paul A. Renhowe , Cynthia Shafer , Darrin Stuart , Sharadha Subramanian
IPC分类号: A61K31/4439 , A61P35/00
CPC分类号: C07D401/14 , Y02P20/55
摘要: New substituted benzimidazole compounds, compositions, and methods of inhibition of kinase activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one serine/threonine kinase or receptor tyrosine kinase. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a serine/threonine kinase- or receptor tyrosine kinase-mediated disorder, such as cancer.
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公开(公告)号:US20100234394A1
公开(公告)日:2010-09-16
申请号:US12759578
申请日:2010-04-13
申请人: Mina E. Aikawa , Payman Amiri , Jeffrey H. Dove , Barry Haskell Levine , Christopher McBride , Teresa E. Pick , Daniel J. Poon , Savithri Ramurthy , Paul A. Renhowe , Cynthia Shafer , Darrin Stuart , Sharadha Subramanian
发明人: Mina E. Aikawa , Payman Amiri , Jeffrey H. Dove , Barry Haskell Levine , Christopher McBride , Teresa E. Pick , Daniel J. Poon , Savithri Ramurthy , Paul A. Renhowe , Cynthia Shafer , Darrin Stuart , Sharadha Subramanian
IPC分类号: A61K31/496 , C07D401/14 , A61K31/4439 , A61K31/444 , A61P35/00
CPC分类号: C07D401/14 , Y02P20/55
摘要: New substituted benzimidazole compounds, compositions, and methods of inhibition of kinase activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one serine/threonine kinase or receptor tyrosine kinase. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a serine/threonine kinase- or receptor tyrosine kinase-mediated disorder, such as cancer.
摘要翻译: 提供了新的取代的苯并咪唑化合物,组合物和抑制与人或动物受试者中的肿瘤发生相关的激酶活性的方法。 在某些实施方案中,化合物和组合物有效地抑制至少一种丝氨酸/苏氨酸激酶或受体酪氨酸激酶的活性。 新化合物和组合物可以单独使用或与至少一种另外的药剂组合使用,用于治疗丝氨酸/苏氨酸激酶或受体酪氨酸激酶介导的病症,例如癌症。
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公开(公告)号:US07482367B2
公开(公告)日:2009-01-27
申请号:US11513959
申请日:2006-08-30
申请人: Mina E. Aikawa , Payman Amiri , Jeffrey H. Dove , Barry Haskell Levine , Christopher McBride , Teresa E. Pick , Daniel J. Poon , Savithri Ramurthy , Paul A. Renhowe , Cynthia Shafer , Darrin Stuart , Sharadha Subramanian
发明人: Mina E. Aikawa , Payman Amiri , Jeffrey H. Dove , Barry Haskell Levine , Christopher McBride , Teresa E. Pick , Daniel J. Poon , Savithri Ramurthy , Paul A. Renhowe , Cynthia Shafer , Darrin Stuart , Sharadha Subramanian
IPC分类号: A61K31/4439 , C07D401/14
CPC分类号: C07D401/14 , Y02P20/55
摘要: New substituted benzimidazole compounds, compositions, and methods of inhibition of kinase activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one serine/threonine kinase or receptor tyrosine kinase. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a serine/threonine kinase- or receptor tyrosine kinase-mediated disorder, such as cancer.
摘要翻译: 提供了新的取代的苯并咪唑化合物,组合物和抑制与人或动物受试者中的肿瘤发生相关的激酶活性的方法。 在某些实施方案中,化合物和组合物有效地抑制至少一种丝氨酸/苏氨酸激酶或受体酪氨酸激酶的活性。 新化合物和组合物可以单独使用或与至少一种另外的药剂组合使用,用于治疗丝氨酸/苏氨酸激酶或受体酪氨酸激酶介导的病症,例如癌症。
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公开(公告)号:US20100216767A1
公开(公告)日:2010-08-26
申请号:US12448390
申请日:2007-12-20
申请人: Mina Aikawa , Payman Amiri , Steven Bashman , Jeffrey Dove , Rama Jain , Xiaodong Lin , Jeremy Murray , Savithri Ramurthy , Alice Rico , Wei Shu , Sharadha Subramanian , Xiaojing Michael Wang , Robert L. Warne , Yasheen Zhou
发明人: Mina Aikawa , Payman Amiri , Steven Bashman , Jeffrey Dove , Rama Jain , Xiaodong Lin , Jeremy Murray , Savithri Ramurthy , Alice Rico , Wei Shu , Sharadha Subramanian , Xiaojing Michael Wang , Robert L. Warne , Yasheen Zhou
IPC分类号: A61K31/337 , C07D239/84 , A61K31/517 , C07D401/12 , A61K31/496 , C07D403/10 , C07D413/10 , A61K31/5377 , C07D413/14 , C07D403/12 , A61P35/00
CPC分类号: C07D239/84 , C07D401/08 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D411/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14
摘要: The invention provides novel compounds that are inhibitors of PDK1. Also provided are pharmaceutical compositions including the compounds, and methods of treating proliferative diseases, such as cancers, with the compounds or compositions.
摘要翻译: 本发明提供了作为PDK1抑制剂的新型化合物。 还提供了包含该化合物的药物组合物,以及用化合物或组合物治疗增殖性疾病如癌症的方法。
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公开(公告)号:US07932262B2
公开(公告)日:2011-04-26
申请号:US12295967
申请日:2007-04-05
申请人: Savithri Ramurthy , Xiaodong Lin , Sharadha Subramanian , Alice Rico , Xiaojong M. Wang , Rama Jain , Jeremy M. Murray , Stephen E. Basham , Robert L. Warne , Wei Shu , Yasheen Zhou , Jeffrey Dove , Mina Aikawa , Payman Amiri , Weibo Wang , Johanna M. Jansen , Allan S. Wagman , Keith B. Pfister , Simon Ng
发明人: Savithri Ramurthy , Xiaodong Lin , Sharadha Subramanian , Alice Rico , Xiaojong M. Wang , Rama Jain , Jeremy M. Murray , Stephen E. Basham , Robert L. Warne , Wei Shu , Yasheen Zhou , Jeffrey Dove , Mina Aikawa , Payman Amiri , Weibo Wang , Johanna M. Jansen , Allan S. Wagman , Keith B. Pfister , Simon Ng
IPC分类号: A61K31/517
CPC分类号: C07D239/94 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/14 , C07D451/06 , C07D453/02
摘要: The invention provides quinazoline compounds that are inhibitors of PDK1. Also provided are pharmaceutical compositions including the compounds, and methods of treating proliferative diseases, such as cancers, with the compounds or compositions.
摘要翻译: 本发明提供作为PDK1抑制剂的喹唑啉化合物。 还提供了包含该化合物的药物组合物,以及用化合物或组合物治疗增殖性疾病如癌症的方法。
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公开(公告)号:US20100048561A1
公开(公告)日:2010-02-25
申请号:US12295967
申请日:2007-04-05
申请人: Savithri Ramurthy , Xiaodong Lin , Sharadha Subramanian , Alice C. Rico , Xiaojing M. Wang , Rama Jain , Jeremy M. Murray , Steven E. Basham , Robert L. Warne , Wei Shu , Yasheen Zhou , Jeffrey Dove , Mina Aikawa , Payman Amiri , Weibo Wang , Johanna M. Jansen , Allan S. Wagman , Keith B. Pfister , Simon Ng
发明人: Savithri Ramurthy , Xiaodong Lin , Sharadha Subramanian , Alice C. Rico , Xiaojing M. Wang , Rama Jain , Jeremy M. Murray , Steven E. Basham , Robert L. Warne , Wei Shu , Yasheen Zhou , Jeffrey Dove , Mina Aikawa , Payman Amiri , Weibo Wang , Johanna M. Jansen , Allan S. Wagman , Keith B. Pfister , Simon Ng
IPC分类号: A61K31/517 , C07D401/12 , C07D401/14 , C07D239/84 , C07D413/14 , A61K31/5377 , A61P35/00
CPC分类号: C07D239/94 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/14 , C07D451/06 , C07D453/02
摘要: The invention provides quinazoline compounds that are inhibitors of PDK1. Also provided are pharmaceutical compositions including the compounds, and methods of treating proliferative diseases, such as cancers, with the compounds or compositions.
摘要翻译: 本发明提供作为PDK1抑制剂的喹唑啉化合物。 还提供了包含该化合物的药物组合物,以及用化合物或组合物治疗增殖性疾病如癌症的方法。
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17.
公开(公告)号:US5656273A
公开(公告)日:1997-08-12
申请号:US422748
申请日:1995-04-14
IPC分类号: A61K38/00 , A61K39/395 , A61K45/00 , A61P1/16 , A61P33/00 , A61P37/00 , C07K14/735 , C07K16/28 , C07K16/42
CPC分类号: C07K16/4291 , C07K14/70535 , C07K16/283 , A61K38/00
摘要: This invention concerns a method for the prevention and treatment of parasitic infection by administering an IgE antagonists. The invention further concerns pharmaceutical compositions and bispecific molecules useful in such method.
摘要翻译: 本发明涉及通过给予IgE拮抗剂来预防和治疗寄生虫感染的方法。 本发明还涉及可用于这种方法的药物组合物和双特异性分子。
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