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    Peptides as active agents to stabilize biological barriers
    11.
    发明授权
    Peptides as active agents to stabilize biological barriers 有权
    肽作为稳定生物屏障的活性剂

    公开(公告)号：US09012403B2

    公开(公告)日：2015-04-21

    申请号：US13702490

    申请日：2011-06-17

    申请人： Peter Petzelbauer ,  Sonja Reingruber

    发明人： Peter Petzelbauer ,  Sonja Reingruber

    IPC分类号： A61K38/00 ,  C07K7/06 ,  C07K7/08 ,  C07K14/705

    CPC分类号： C07K7/06 ,  A61K38/00 ,  C07K7/08 ,  C07K14/705

    摘要： The present invention relates to compounds, in particular peptides which are capable of stabilizing barrier functions of epithelium and endothelium. The peptides and other compounds of the present invention are useful in the treatment and prevention of diseases or disorders associated with a localized or systemic breakdown of epithelial and endothelial barrier functions. Particular diseases and disorders to be treated and/or prevented with the peptides or other compounds, methods and uses provided herein are burns, acute lung injury (ALI), acute respiratory distress syndrome (ARDS), ventilator induced lung injury (VILI), systemic inflammatory response syndrome (SIRS), acute kidney injury (AKI), sepsis, multiorgan dysfunction syndrome (MODS), or edema.

    摘要翻译： 本发明涉及能够稳定上皮和内皮的屏障功能的化合物，特别是肽。 本发明的肽和其它化合物可用于治疗和预防与上皮和内皮屏障功能的局部或全身分解相关的疾病或病症。 用肽或其他化合物治疗和/或预防的特殊疾病和病症，本文提供的方法和用途是烧伤，急性肺损伤（ALI），急性呼吸窘迫综合征（ARDS），呼吸机诱导的肺损伤（VILI），系统性 炎性反应综合征（SIRS），急性肾损伤（AKI），败血症，多器官功能障碍综合征（MODS）或水肿。

    PEPTIDES AS ACTIVE AGENTS TO STABILIZE BIOLOGICAL BARRIERS
    12.
    发明申请
    PEPTIDES AS ACTIVE AGENTS TO STABILIZE BIOLOGICAL BARRIERS 有权
    作为促进生物障碍的主动药剂

    公开(公告)号：US20130143791A1

    公开(公告)日：2013-06-06

    申请号：US13702490

    申请日：2011-06-17

    申请人： Peter Petzelbauer ,  Sonja Reingruber

    发明人： Peter Petzelbauer ,  Sonja Reingruber

    IPC分类号： C07K7/06 ,  C07K7/08

    CPC分类号： C07K7/06 ,  A61K38/00 ,  C07K7/08 ,  C07K14/705

    摘要： The present invention relates to compounds, in particular peptides which are capable of stabilizing barrier functions of epithelium and endothelium. The peptides and other compounds of the present invention are useful in the treatment and prevention of diseases or disorders associated with a localized or systemic breakdown of epithelial and endothelial barrier functions. Particular diseases and disorders to be treated and/or prevented with the peptides or other compounds, methods and uses provided herein are burns, acute lung injury (ALI), acute respiratory distress syndrome (ARDS), ventilator induced lung injury (VILI), systemic inflammatory response syndrome (SIRS), acute kidney injury (AKI), sepsis, multiorgan dysfunction syndrome (MODS), or edema.

    摘要翻译： 本发明涉及能够稳定上皮和内皮的屏障功能的化合物，特别是肽。 本发明的肽和其它化合物可用于治疗和预防与上皮和内皮屏障功能的局部或全身分解相关的疾病或病症。 用肽或其他化合物治疗和/或预防的特殊疾病和病症，本文提供的方法和用途是烧伤，急性肺损伤（ALI），急性呼吸窘迫综合征（ARDS），呼吸机诱导的肺损伤（VILI），系统性 炎性反应综合征（SIRS），急性肾损伤（AKI），败血症，多器官功能障碍综合征（MODS）或水肿。

    Pharmaceutical composition for treating haemorrhagic shock and its consecutive symptoms
    14.
    发明授权
    Pharmaceutical composition for treating haemorrhagic shock and its consecutive symptoms 失效
    用于治疗出血性休克及其连续症状的药物组合物

    公开(公告)号：US07897574B2

    公开(公告)日：2011-03-01

    申请号：US12158670

    申请日：2006-11-10

    申请人： Peter Petzelbauer ,  Rainer Henning

    发明人： Peter Petzelbauer ,  Rainer Henning

    IPC分类号： A61K38/36

    CPC分类号： A61K38/16 ,  Y02A50/411

    摘要： The invention is concerned with the use of a peptide comprising the N-terminal sequence Gly-His-Arg-Pro-Leu-Asp-Lys-Lys-Arg-Glu-Glu-Ala-Pro-Ser-Leu-Arg-Pro-Ala- Pro-Pro-Pro-Ile-Ser-Gly-Gly-Gly-Tyr-Arg (SEQ ID NO: 1) or any allelic variant or derivative of said peptide possessing the biological property of matching the inducible VE-cadherin binding motif on the Bβ-chain (i.e. Bβ15-42) of human fibrin for the preparation of a pharmaceutical preparation for the treatment of shock, more specifically of hemorrhagic shock.

    摘要翻译： 本发明涉及使用包含N-末端序列Gly-His-Arg-Pro-Leu-Asp-Lys-Lys-Arg-Glu-Glu-Ala-Pro-Ser-Leu-Arg-Pro- （SEQ ID NO：1）或具有与诱导型VE-钙粘蛋白结合基序匹配的生物学特性的所述肽的任何等位基因变体或衍生物（Pro-Pro-Pro-Pro-Ile-Ser-Gly-Gly-Gly-Tyr-Arg 在人类纤维蛋白的B＆bgr-chain（即B＆Bgr; 15-42）上制备用于治疗休克的药物制剂，更具体地说是出血性休克。

    (En) Pharmaceutical Composition for Treating Haemorrhagic Shock and its Consecutive Symptoms
    15.
    发明申请
    (En) Pharmaceutical Composition for Treating Haemorrhagic Shock and its Consecutive Symptoms 失效
    （En）用于治疗出血性休克及其连续症状的药物组合物

    公开(公告)号：US20090005310A1

    公开(公告)日：2009-01-01

    申请号：US12158670

    申请日：2006-11-10

    申请人： Peter Petzelbauer ,  Rainer Henning

    发明人： Peter Petzelbauer ,  Rainer Henning

    IPC分类号： A61K38/17 ,  A61P7/04 ,  C12Q1/02

    CPC分类号： A61K38/16 ,  Y02A50/411

    摘要： The invention is concerned with the use of a peptide comprising the N-terminal sequence Gly-His-Arg-Pro-Leu-Asp-Lys-Lys-Arg-Glu-Glu-Ala- Pro-Ser-Leu-Arg-Pro-Ala-Pro-Pro-Pro-Ile-Ser-Gly- Gly-Gly-Tyr-Arg or any allelic variant or derivative of said peptide possessing the biological property of matching the inducible VE-cadherin binding motif on the Bβ-chain (i.e. Bβ15-42) of human fibrin for the preparation of a pharmaceutical preparation for the treatment of shock, more specifically of hemorrhagic shock.

    摘要翻译： 本发明涉及使用包含N-末端序列的肽

    Pro-Ser-Leu-Arg-Pro-Ala-Pro -Pro-Pro-Ile-Ser-Gly - Gly-Gly-Tyr-Arg 或具有与Bbeta链上的诱导型VE-钙粘蛋白结合基序匹配的生物学特性的所述肽的任何等位基因变体或衍生物（即Bbeta15 -42），用于制备用于治疗休克的药物制剂，更具体地说是出血性休克。

      Therapeutic fibrin-derived peptides and uses thereof
      16.
      发明申请
      Therapeutic fibrin-derived peptides and uses thereof 有权
      治疗性纤维蛋白衍生肽及其用途

      公开(公告)号：US20090137464A1

      公开(公告)日：2009-05-28

      申请号：US11899611

      申请日：2007-09-06

      申请人： Peter Petzelbauer

      发明人： Peter Petzelbauer

      IPC分类号： A61K38/16

      CPC分类号： A61K38/363 ,  A61K39/00 ,  C07K5/0806 ,  C07K5/1008 ,  C07K14/75

      摘要： The invention relates to peptides having the general formula (I), or a salt or amide thereof, wherein R1 and R2 are either the same or different, wherein R1 and R2 are each selected from the group consisting of hydrogen and a saturated or unsaturated hydrocarbon residue, said residue having from 1 to 10 carbon atoms, wherein Z1 is selected from the group consisting of histidine and proline, wherein Z2 is selected from the group consisting of an arginine and a peptide comprising an initial arginine and having from 2 to 30 amino acids. The invention also relates to methods using the peptides of the present invention in the treatment of inflammation.

      摘要翻译： 本发明涉及具有通式（I）的肽或其盐或酰胺，其中R 1和R 2可以相同或不同，其中R 1和R 2各自选自氢和饱和或不饱和烃 残基，所述残基具有1至10个碳原子，其中Z1选自组氨酸和脯氨酸，其中Z2选自精氨酸和包含初始精氨酸的肽，并具有2至30个氨基 酸。 本发明还涉及使用本发明的肽治疗炎症的方法。

      Therapeutic Fibrin-Derived Peptides And Uses Thereof
      17.
      发明申请
      Therapeutic Fibrin-Derived Peptides And Uses Thereof 有权
      治疗性纤维蛋白衍生肽及其用途

      公开(公告)号：US20090088384A1

      公开(公告)日：2009-04-02

      申请号：US12248656

      申请日：2008-10-09

      申请人： Peter Petzelbauer

      发明人： Peter Petzelbauer

      IPC分类号： A61K38/16

      CPC分类号： A61K38/363 ,  A61K39/00 ,  C07K5/0806 ,  C07K5/1008 ,  C07K14/75

      摘要： The invention relates to peptides having the general formula (I), or a salt or amide thereof, wherein R1 and R2 are either the same or different, wherein R1 and R2 are each selected from the group consisting of hydrogen and a saturated or unsaturated hydrocarbon residue, said residue having from 1 to 10 carbon atoms, wherein Z1 is selected from the group consisting of histidine and proline, wherein Z2 is selected from the group consisting of an arginine and a peptide comprising an initial arginine and having from 2 to 30 amino acids. The invention also relates to methods using the peptides of the present invention in the treatment of inflammation.

      摘要翻译： 本发明涉及具有通式（I）的肽或其盐或酰胺，其中R 1和R 2可以相同或不同，其中R 1和R 2各自选自氢和饱和或不饱和烃 残基，所述残基具有1至10个碳原子，其中Z1选自组氨酸和脯氨酸，其中Z2选自精氨酸和包含初始精氨酸的肽，并具有2至30个氨基 酸。 本发明还涉及使用本发明的肽治疗炎症的方法。

      Therapeutic fibrin-derived peptides and uses thereof
      19.
      发明授权
      Therapeutic fibrin-derived peptides and uses thereof 有权

      公开(公告)号：US07494973B2

      公开(公告)日：2009-02-24

      申请号：US11542050

      申请日：2006-10-03

      申请人： Peter Petzelbauer

      发明人： Peter Petzelbauer

      IPC分类号： A61K38/00

      CPC分类号： A61K38/363 ,  A61K39/00 ,  C07K5/0806 ,  C07K5/1008 ,  C07K14/75

      摘要： The invention relates to peptides having the general formula (I), or a salt or amide thereof, wherein R1 and R2 are either the same or different, wherein R1 and R2 are each selected from the group consisting of hydrogen and a saturated or unsaturated hydrocarbon residue, said residue having from 1 to 10 carbon atoms, wherein Z1 is selected from the group consisting of histidine and proline, wherein Z2 is selected from the group consisting of an arginine and a peptide comprising an initial arginine and having from 2 to 30 amino acids. The invention also relates to methods using the peptides of the present invention in the treatment of inflammation.

      Pharmaceutical Preparation for the Treatment of Shock
      20.
      发明申请
      Pharmaceutical Preparation for the Treatment of Shock 审中-公开
      用于治疗休克的药物制剂

      公开(公告)号：US20080249006A1

      公开(公告)日：2008-10-09

      申请号：US10596103

      申请日：2005-06-24

      申请人： Peter Petzelbauer ,  Kai Zacharowski

      发明人： Peter Petzelbauer ,  Kai Zacharowski

      IPC分类号： A61K38/16 ,  A61K38/06 ,  A61P25/00 ,  A61K38/08

      CPC分类号： A61K38/363 ,  Y02A50/385

      摘要： The invention relates to the use of a peptide of general Formula I wherein R1 and R2, being equal or different, denote hydrogen, a saturated or unsaturated hydrocarbon moiety comprising from 1 to 10, in particular from 1 to 3, carbon atoms, Z1 denotes a histidine or proline moiety, Z2 denotes an arginine moiety, a peptide moiety or a protein moiety comprising an initial arginine moiety, in particular comprising from 2 to 30 amino acids, which peptide has the biological property of matching the inducible VE-cadherin binding motif on the Bβ-chain (i.e. Bβ15-42) of human fibrin, for the preparation of a pharmaceutical preparation for the treatment of shock.

      摘要翻译： 本发明涉及通式I的肽的用途，其中R 1和R 2等于或不同表示氢，饱和或不饱和的烃部分包含 1至10，特别是1至3个碳原子，Z 1表示组氨酸或脯氨酸部分，Z 2表示精氨酸部分，肽部分或蛋白质 部分包含初始精氨酸部分，特别是包含2-30个氨基酸，该肽具有将Bbeta链上诱导型VE-钙粘蛋白结合基序匹配的生物学特性（即Bβ15-42） ）的人纤维蛋白，用于制备用于治疗休克的药物制剂。