公开(公告)号：US20220273820A1

公开(公告)日：2022-09-01

申请号：US17565921

申请日：2021-12-30

Applicant: BioNTech SE

Inventor： Ugur Sahin ,  Alptekin Güler ,  Andreas Kuhn ,  Alexander Muik ,  Annette Vogel ,  Kerstin Walzer ,  Sonja Witzel ,  Stephanie Hein ,  Özlem Türeci ,  Gábor Boros ,  Azita Josefine Mahiny ,  Jonas Reinholz ,  Katalin Karikó

IPC: A61K48/00 ,  A61K9/127 ,  A61K39/215 ,  C12N7/00

Abstract: Disclosed herein are RNA polynucleotides comprising a 5′ Cap, a 5′ UTR comprising a cap proximal sequence disclosed herein, and a sequence encoding a payload. Also disclosed herein are compositions and medical preparations comprising the same, and methods of making and using the same.

公开(公告)号：US20220249372A1

公开(公告)日：2022-08-11

申请号：US17727956

申请日：2022-04-25

Applicant: BioNTech SE ,  Tron-Translationale Onkologie an der Universitatsmedizin der Johannes Gutenberg-University Mainz Gmb

Inventor： Hossam Hefesha ,  Ugur Sahin ,  Heinrich Haas ,  Sebastian Kreiter ,  Yves Hüsemann ,  Mustafa Diken ,  Kerstin Walzer

IPC: A61K9/107 ,  A61K9/127 ,  A61K48/00 ,  A61K31/675 ,  A61K31/7105 ,  A61K9/00 ,  A61K31/663 ,  A61K45/06 ,  A61K39/395 ,  A61P35/00 ,  A61K39/00 ,  A61K47/18 ,  A61K47/24

Abstract: The present invention relates to lipid particles comprising at least one cationic lipid, at least one water-soluble therapeutically effective compound and RNA. Further, the present invention relates to a pharmaceutical composition comprising such particles. Said pharmaceutical composition is useful for inducing an immune response. It is also useful in a prophylactic and/or therapeutic treatment of a disease involving an antigen. Furthermore, the present invention relates to a method for producing the particles.