公开(公告)号：US20110301695A1

公开(公告)日：2011-12-08

申请号：US12795712

申请日：2010-06-08

申请人： ROBERT E. FISCHELL

发明人： ROBERT E. FISCHELL

IPC分类号： A61F2/82

CPC分类号： A61F2/91 ,  A61F2250/0067 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/608 ,  A61L2420/08

摘要： Disclosed is a stent that allows rapid coverage of the stent's luminal surface with endothelial cells while eluting enough anti-restenosis drug from the stent's abluminal surface to eliminate restenosis. A delay in the release of the anti-restenosis drug from the abluminal surface of the stent struts is created by a drug-free biodegradable polymer that covers that abluminal surface of the stent The anti-restenosis drug being only on the abluminal surface of the stent and the release of that drug being delayed by the outer polymer covering of that abluminal surface allows endothelial cells to have unconstrained mitosis so that they quickly cover the stent's luminal surface. It is further conceived to cover the luminal surface of the stent with an anti-thrombogenic coating such as carbon to further encourage endothelial cell coverage while deterring the deposition of platelets.

摘要翻译： 公开了一种支架，其允许用内皮细胞快速覆盖支架的腔表面，同时从支架的外膜表面洗脱足够的抗再狭窄药物以消除再狭窄。 通过覆盖支架外膜面的无药物生物可降解聚合物产生抗再狭窄药物从支架支柱的外膜表面释放的延迟抗再狭窄药物仅在支架的外膜表面上 并且被该外膜表面的外部聚合物覆盖延迟的该药物的释放允许内皮细胞具有无约束的有丝分裂，使得它们快速覆盖支架的腔表面。 还设想用抗血栓形成的涂层例如碳覆盖支架的腔表面，以进一步促进内皮细胞覆盖，同时阻止血小板的沉积。