公开(公告)号：US20140350119A1

公开(公告)日：2014-11-27

申请号：US14460564

申请日：2014-08-15

Applicant: ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Takayuki MIYANO ,  Takahiro KUROSE ,  Mariyo KATO ,  Yoshihiro TAKAI

IPC: A61K31/121

CPC classification number: A61K31/121 ,  A61K9/0048 ,  A61K47/02 ,  A61K47/26 ,  A61K47/44

Abstract: An ophthalmic composition comprising geranylgeranylacetone which (a) is a mixture of (5E,9E,13E)-geranylgeranylacetone and (5Z,9E,13E)-geranylgeranylacetone, the (5E,9E,13E)-geranylgeranylacetone content of the mixture being 80% by weight or more, (b) consists of (5E,9E,13E)-geranylgeranylacetone, or (c) consists of (5Z,9E,13E)-geranylgeranylacetone protects various types of retinal cells from degeneration, impairment or destruction, thereby remarkably promoting the survival. Consequently, the composition exhibits a remarkable effect of preventing, ameliorating or treating various retinal diseases. In addition, the composition hardly becomes white turbid during storage.

Abstract translation: （a）是（5E，9E，13E）ger anyl ger anyl anyl one one one and and ger ger ger ger ger ger ger ger ger ger ger An An An An An An An An ger ger％％％％％％％％％％％％％％％％％％％％％％％％％％ （5E，9E，13E） - ger ger ger ger anyl anyl anyl，，，，ger ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably 促进生存。 因此，该组合物显示出预防，改善或治疗各种视网膜疾病的显着效果。 此外，组合物在储存期间几乎不变成白色混浊。

公开(公告)号：US20130331458A1

公开(公告)日：2013-12-12

申请号：US13775547

申请日：2013-02-25

Applicant: ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Takayuki MIYANO ,  Takahiro KUROSE

IPC: A61K31/121

CPC classification number: A61K31/121 ,  A01N1/0226 ,  A61K9/0048 ,  A61K47/02 ,  A61K47/24 ,  A61K47/26 ,  A61K47/44 ,  A61L12/12 ,  B65D65/38 ,  Y10T428/1397

Abstract: An ophthalmic composition kit comprising an ophthalmic container holding an ophthalmic composition comprising geranylgeranylacetone, the ophthalmic container having a surface in contact with the ophthalmic composition, the surface being at least partially or wholly made of a container material selected from the group consisting of a polyolefin, an acrylic acid resin, a terephthalic acid ester, a polycarbonate, a polymethylterpene, a fluorine resin and a glass,the ophthalmic composition kit having an advantage that the loss of the geranylgeranylacetone content or decrease in the geranylgeranylacetone concentration in the ophthalmic composition is very little.

Abstract translation: 一种眼用组合物试剂盒，其包含容纳含有香叶基香叶基丙酮的眼用组合物的眼用容器，所述眼用容器具有与所述眼用组合物接触的表面，所述表面至少部分或全部由选自以下的容器材料制成：聚烯烃， 丙烯酸树脂，对苯二甲酸酯，聚碳酸酯，聚甲基萜烯，氟树脂和玻璃，眼用组合物试剂盒具有以下优点，即眼用组合物中er牛ger牛儿基丙酮含量的损失或香叶基香叶基丙酮浓度的降低非常小 。

公开(公告)号：US20130303624A1

公开(公告)日：2013-11-14

申请号：US13775524

申请日：2013-02-25

Applicant: ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Takayuki MIYANO ,  Takahiro KUROSE ,  Mariyo KATO ,  Yoshihiro TAKAI

IPC: A61K31/121 ,  A61K9/00

CPC classification number: A61K31/121 ,  A61K9/0048 ,  A61K47/02 ,  A61K47/26 ,  A61K47/44

Abstract: An ophthalmic composition comprising geranylgeranylacetone which (a) is a mixture of (5E,9E,13E)-geranylgeranylacetone and (5Z,9E,13E)-geranylgeranylacetone, the (5E,9E,13E)-geranylgeranylacetone content of the mixture being 80% by weight or more, (b) consists of (5E,9E,13E)-geranylgeranylacetone, or (c) consists of (5Z,9E,13E)-geranylgeranylacetone protects various types of retinal cells from degeneration, impairment or destruction, thereby remarkably promoting the survival. Consequently, the composition exhibits a remarkable effect of preventing, ameliorating or treating various retinal diseases. In addition, the composition hardly becomes white turbid during storage.

Abstract translation: （a）是（5E，9E，13E）ger anyl ger anyl anyl one one one and and ger ger ger ger ger ger ger ger ger ger ger An An An An An An An An ger ger％％％％％％％％％％％％％％％％％％％％％％％％％％ （5E，9E，13E） - ger ger ger ger anyl anyl anyl，，，，ger ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably 促进生存。 因此，该组合物显示出预防，改善或治疗各种视网膜疾病的显着效果。 此外，组合物在储存期间几乎不变成白色混浊。